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Training Grant-
Biology of Aging

Karen Hansen

Karen E. Hansen

M.D., M.S., University of Wisconsin-Madison
Associate Professor, Department of Medicine- Rheumatology

Osteoporosis and Related Topics: Factors Affecting Calcium Absorption

Dr. Hansen has multiple research projects involving osteoporosis and other rheumatic diseases. NIH sponsored research includes a randomized, placebo-controlled clinical trial in which postmenopausal women with vitamin D insufficiency are treated with placebo, low-dose or high-dose vitamin D. Study outcomes include changes in calcium absorption, bone mineral density and muscle fitness.

Recent research efforts include evaluating the effects of proton pump inhibitors and aromatase inhibitors on calcium absorption. Future research efforts will focus on the long-term use of proton pump inhibitors and whether these medications affect calcium absorption and bone mineral density.

Representative Publications
Hanseree, P., Staples, A.C., Cryns, V., & Hansen, K.E. (2017). Hypocalciuria as a predictor of reduced intestinal calcium absorption. Journal of the Endocrine Society, 1(9), 1179-1187.
View publication via DOI: DOI:10.1210/js.2017-00234

Hansen, K.E, Binkley, N., & Ney, D.M. (2017). High fracture rates in young patients with phenylketonuria. Annals of Nutrition & Metabolism 72(1), 1-2.
View publication via DOI: DOI:10.1159/000484617

Bucci, J., Staples, A.C., & Hansen, K.E. (2017). Bioactive Vitamin D therapy to treat secondary hyperparathyroidism in patients with pre-dialysis chronic kidney disease: A systematic review. International Journal of Clinical Endocrinology, 1(1), 25-32.

Caplan, L., Hansen, K.E., & Saag, K.G. (2017). Response to the American college of physicians osteoporosis guideline, 2017 update. Arthritis & Rheumatology, 69(11), 2097-2101.
View publication via DOI: DOI:10.1002/art.40305

Stroup, B.M., Sawin, E.A., Murali, S.G., Binkley, N., Hansen, K.E., & Ney, D.M. (2017). Amino acid medical foods provide a high dietary acid load and increase urinary excretion of renal net acid, calcium and magnesium compared with glycomacropeptide medical foods in phenylketonuria. Journal of Nutrition and Metabolism. Advanced online publication.
View publication via DOI: DOI:10.1155/2017/1909101

Buckley, L., Guyatt, G.H., Fink, H., Cannon, M., Grossman, J., Hansen, K.E., Humphrey, M.B., Lane, N., Magrey, M., Morrison, L., Rao, M., Robinson, A., Saha, S., Wolver, S., Bannuru, R., Vaysbrot, E., Osani, M., Turgunbaev, M., Evans, L., Miller, A., McAl (2017). 2017 American college of rheumatology guideline for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis Care & Research, 69(8), 1095-1110.
View publication via DOI: DOI:10.1002/acr.23279

Buckley, L., Guyatt, G.H., Fink, H., Cannon, M., Grossman, J., Hansen, K.E., Humphrey, M.B., Lane, N., Magrey, M., Morrison, L., Rao, M., Robinson, A., Saha, S., Wolver, S., Bannuru, R., Vaysbrot, E., Osani, M., Turgunbaev, M., Evans, L., Miller, A., McAl (2017). 2017 American college of rheumatology guideline for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis & Rheumatology, 69(8), 1521-1537.
View publication via DOI: DOI:10.1002/art.40137

Arentsen, L., Hansen, K.E., Yagi, M., Takahashi, Y., Shanley, R., McArthur, A., Magome, T., Yee, D., Froelich, J., & Hui, S. (2017). Use of dual energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density. Journal of Bone and Mineral Metabolism, 35(4), 428-436.
View publication via DOI: DOI:10.1007/s00774-016-0796-1

Bartels, C. M., Roberts, T. J., Hansen, K. E., Jacobs, E. A., Gilmore, A., Maxcy, C., & Bowers, B. J. (2016). Rheumatologist and primary care management of cardiovascular disease risk in rheumatoid arthritis: Patient and provider perspectives. Arthritis Care and Research, 68(4), 415-423.
View publication via DOI: DOI:10.1002/acr.22689

Hansen, K.E., & Johnson, M.G. (2016). Proposed guidelines for future vitamin D studies-reply. Journal of the American Medical Association Internal Medicine, 176(2), 281-282.
View publication via DOI: DOI:10.1001/jamainternmed.2015.7983

Medlin, J. L., Hansen, K. E., Fitz, S. R., & Bartels, C. M. (2016). A systematic review and meta-analysis of cutaneous manifestations in late versus early-onset systemic lupus erythematosus. Seminars in Arthritis and Rheumatism, 45(6), 691-697.
View publication via DOI: DOI:10.1016/j.semarthrit.2016.01.004

Hansen, K. E., & Johnson, M. G. (2016). An update on vitamin D for clinicians. Current Opinion in Endocrinology, Diabetes, and Obesity, 23(6), 440-444.
View publication via DOI: DOI:10.1097/MED.0000000000000288

Hui, S. K., Arentsen, L., Sueblinvong, T., Brown, K., Bolan, P., Ghebre, R. G., Downs, L., Shanley, R., Hansen, K. E. . . . Yee, D. (2015). A phase I feasibility study of multi-modality imaging assessing rapid expansion of marrow fat and decreased bone mineral density in cancer patients. Bone, 73, 90-97.
View publication via DOI: DOI:10.1016/j.bone.2014.12.014

Hansen, K. E., Johnson, R. E., Chambers, K. R., Johnson, M. G., Lemon, C. C., Vo, T. N., & Marvdashti, S. (2015). Treatment of vitamin D insufficiency in postmenopausal women: A randomized clinical trial. JAMA Internal Medicine, 175(10), 1612-1621.
View publication via DOI: DOI:10.1001/jamainternmed.2015.3874

Vreede, A. P., Jones, A. N., & Hansen, K. E. (2015). Can serum isotope levels accurately measure intestinal calcium absorption compared to gold-standard methods? Nutrition Journal, 14(1), 1-8.
View publication via DOI: DOI:10.1186/s12937-015-0065-5

Hansen, K. E., Bartels, C. M., Gangnon, R. E., Jones, A. N., & Gogineni, J. (2014). An evaluation of high-dose vitamin D for rheumatoid arthritis. Journal of Clinical Rheumatology, 20(2), 112-114.
View publication via DOI: DOI:10.1097/RHU.0000000000000072

Ramsubiek, K., Keuler, N. S., Davis, L. A., & Hansen, K. E. (2014). Factors associated with calcium absorption in postmenopausal women: A post-hoc analysis of dual isotope studies. Journal of the Academy of Nutrition and Dietetics, 114(5), 761-7.
View publication via DOI: DOI:10.1016/j.jand.2013.07.041

Ney, D. N., Blank, R. D., & Hansen, K. E. (2014). Advances in the nutritional and phamcological management of phenylketonuria. Current Opinion in Clinical Nutrition and Metabolic Care, 17(1), 61-8.
View publication via DOI: DOI:10.1097/MCO.0000000000000002

Nabak, A., Johnson, R.E., Keuler, N.S., & Hansen, K.E. (2014). Can a questionnaire predict vitamin D status in postmenopausal women? Public Health Nutrition, 17(4), 739-746.
View publication via DOI: DOI:10.1017/S1368980013001973

Hansen, K.E., Nabak, A.C., Johnson, R.E., Marvdashti, S., Keuler, N.S., & Shafer, M.M. (2014). Abrams SA: Isotope concentrations from 24-h urine and a 3-h serum sample can be used to measure intestinal magnesium absorption in postmenopausal women. The Journal of Nutrition, 144(4), 533-537.
View publication via DOI: DOI:10.3945/jn.113.186767

Hansen, K.E., Kleker, B., Safdar, N., & Bartels, C.M. (2014). A systematic review and meta-analysis of glucocorticoid-induced osteoporosis in children. Seminars in Arthritis and Rheumatism, 44(1), 47-54.
View publication via DOI: DOI:10.1016/j.semarthrit.2014.02.002

Hansen, K.E., Blank, R.D., Jones, A.N., Palermo, L., Fink, H., & Orwoll, E. (2014). What analytic method should clinicians use to derive spine T-scores and predict incident fractures in men? Results from the MrOS study. Osteoporosis International, 25(9), 2181-2188.
View publication via DOI: DOI:10.1007/s00198-014-2744-z

Hansen, K.E., & Ney, D.N. (2014). A systematic review of bone mineral density and fractures in phenylketonuria. Journal of Inherited Metabolic Disease, 37(6), 875-880.
View publication via DOI: DOI:10.1007/s10545-014-9735-2

Swenson, E., Hansen, K., Jones, A., Li, Z., Baltz-Ward, B., Schuna, A., & Elliott, M. (2013). Characteristics associated with bone mineral density responses to alendronate in men. Calcified Tissue International, 92(6), 548-556.
View publication via DOI: DOI:10.1007/s00223-013-9715-9

Nabak, A. C., Johnson, R. E., Keuler, N. S., & Hansen, K. E. (2013). Can a questionnaire predict vitamin D status in postmenopausal women? Public Health Nutrition, FirstView. Advance online publication.
View publication via DOI: DOI:10.1017/S1368980013001973

Jones, A.N., Shafer, M.M., Keuler, N.S., Crone, E.M., Hansen, K.E. (2012). Fasting and post-prandial spot urine calcium-to-creatinine ratios do not diagnose hypercalciuria. Osteoporosis International, 23(2), 553-562.
View publication via DOI: DOI:10.1007/s00198-011-1580-7

Tevaarwerk, A., Burkard, M.E., Wisinski, K.B., Shafer, M.M., Davis, L.A., Gogineni, J., Crone, E.M., & Hansen, K.E. (2012). Aromatase inhibitors and calcium absorption in early stage breast cancer. Breast Cancer Research and Treatment, 134(1), 245-251.
View publication via DOI: DOI:10.1007/s10549-012-1982-z

Bartels, C.M., Saucier, J.M., Thorpe, C.T., Kind, A.J., Pandhi, N., Hansen, K.E., & Smith, M.A. (2012). Monitoring diabetes in patients with and without rheumatoid arthritis: a Medicare study. Arthritis Research and Therapy, 14(4).
View publication via DOI: DOI:10.1186/ar3915

Hansen, K.E. (2011). High-Dose Vitamin D: Helpful or Harmful? Current Rheumatology Reports, 13(3), 257-64.

Shapses, S.A., Kendler, D., Robson, R., Hansen, K.E., Sherrell, R., Field, P. ... Santora, A. (2011). Effect of alendronate and vitamin D3 on fractional calcium absorption in a double-blind, randomized, placebo-controlled trial in postmenopausal osteoporotic women. Journal of Bone and Mineral Research, 26(8), 1836-44.
View publication via DOI: DOI:10.1002/jbmr.395

Hansen, K.E., Wilson, H.A., Zapalowski, C., Fink, H.A., Minisola, S., & Adler, R.A. (2011). Uncertainties in the prevention and treatment of glucocorticoid-induced osteoporosis. Journal of Bone and Mineral Research, 26(9), 1989-96.
View publication via DOI: DOI:10.1002/jbmr.362

Nansera, D., Graziano, F.M., Freedman, D.J., Bobbs, M.K., Jones, A.N., & Hansen, K.E. (2011). Vitamin D and calcium levels in Ugandan adults with human immunodeficiency virus and tuberculosis. International Journal of Tuberculosis and Lung Disease, 15(11), 1522-7.
View publication via DOI: DOI:10.5588/ijtld.10.0701

Kiehn, K., Mahoney, J., Jones, A.N., & Hansen, K.E. (2009). Vitamin D supplement intake in elderly fallers. Journal of the American Geriatrics Society, 57(1), 176-177.
Click here to download this publication.
View publication via DOI: DOI:10.1111/j.1532-5415.2009.02065.x

Hansen, K.E. (2009). Osteoimmunology: Prevalence of hypovitaminosis D and relationship to fracture. Nature Reviews Rheumatology, 5(8), 417-418.
View publication via DOI: DOI:10.1038/nrrheum.2009.143

Penniston, K.L., Jones, A.N., Nakada, S.Y., & Hansen, K.E. (2009). Vitamin D repletion does not alter urinary calcium excretion in healthy postmenopausal women. British Journal of Urology International, 104(10), 1512-1516.
Click here to download this publication.
View publication via DOI: DOI:10.1111/j.1464-410X.2009.08559.x

Jones, A. N., Blank, R. D., Lindstrom, M. J., Penniston, K. L., & Hansen, K. E. (2009). Adjustment for body mass index and calciotropic hormone levels improves the diagnostic accuracy of the spot urine calcium to creatinine ratio. Osteoporosis International, 2(8), 1417-1425.

Hansen, K.E., Swenson, E.D., Baltz, B., et al. (2008). Adherence to alendronate in male veterans. Osteoporosis International, 19(3), 349-35.

Hansen, K.E., Jones, A.N., Lindstrom, M.J., et al. (2008). Vitamin D insufficiency: Disease or no disease? Journal of Bone and Mineral Research, 23(7), 1052-106.

Wolff, A.E., Jones, A.N., & Hansen, K.E. (2008). Vitamin D and musculoskeletal health. Nature Clinical Practice Rheumatology, 4 (11), 580-58.
View publication via DOI: DOI:10.1038/ncprheum0921

Hansen, K.E. (2008). Optimal vitamin D status. Journal of Bone and Mineral Research, 24(4),,756.
View publication via DOI: DOI:10.1359/JBMR.08121

Hansen, K.E., Swenson, E.D., Baltz, B., Schuna, A.A., Jones, A.N., & Elliott, M.E. (2008). Adherence to alendronate in male veterans. Osteoporosis Int., 19(3), 349-356.
View publication via DOI: DOI:10.1007/s00198-007-0471-4

Swenson, E.D., Elliott, M.E., Baltz, B.L., Schuna, A.A., & Hansen, K.E. (2008). Patient characteristics associated with bone mineral density (BMD) responses to alendronate. Journal of Clinical Densitometry, 11(3), 458.

Hansen, K.E., Rosenblatt, E.R., Gjerde, C.L., & Crowe, M.C. (2007). Can a web-based osteoporosis lecture increase physician knowledge and improve patient care? Journal of Clinical Densitometry, 10(1), 10-2.

Hansen, K.E., Binkley, N., Blank, R.D., Krueger, D.C., Christian, R.C., Malone, D.G., & Baim, S. (2007). An atlas improves interobserver agreement regarding application of the ISCD Vertebral Body Exclusion Criteria. Journal of Clinical Densitometry, 10(4), 359-6.
View publication via DOI: DOI:10.1016/j.jocd.2007.08.003

Blank, R.D., Malone, D.G., Christian, R.C., Vallarta-Ast, N., Krueger, D., Drezner, M.K., Binkley, N., & Hansen, K.E. (2006). Patient variables impact lumbar spine dual energy x-ray absorptiometry precision. Osteoporosis Int., 17, 768-74.
View publication via DOI: DOI:10.1007/s00198-005-0050-5

Hansen, K.E., Hofmann, R.M., Drake, R.K., Argall, T.R., Bier, H.A., Grigg, K.T., Rouse, E.D., Elliott, M.E. (2006). An exploratory analysis of alendronate in older men with low creatinine clearance. J. Aging Pharmacother., 13, 21-33.
View publication via DOI: DOI:10.1300/J397v13n02_03

Hansen, K.E., Baltz, B.L., Swenson, E.D., Schuna, A.A., Elliott, M.E. (2006). Adherence to alendronate among male veterans. J. Bone Miner. Res., 21(Suppl 1), SA350.

Johnson, S.C., Schmitz, T.W., Moritz, C.H., Meyerand, M.E., Rowley, H.A., Alexander, A.L., Hansen, K.W., Gleason, C.E., Carlsson, C.M., Ries, M.L., Asthana, S., Chen, K., Reiman, E.M., & Alexander, G.E. (2006). Activation of brain regions vulnerable to Alzheimer's disease: The effect of mild cognitive impairment. Neurobiology of Aging, 27, 1604-161.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2005.09.017

Hansen, K.E., Hildebrand, J.P., Ferguson, E.E., & Stein, J.H. (2005). Outcomes in 45 patients with statin-associated myopathy. Arch. Intern. Med., 165, 2671-2676.

Christian, R., & Hansen, K.E. (2005). Transplant osteoporosis. Curr. Opin. Orthop., 16, 382-386.

Khurma, V., Appen, R., Wolf, M.D., & Hansen, K.E. (2005). Wegener Granulomatosis presenting as bilateral loss of vision. J. Clin. Rheumatol., 11, 267-269.

Hansen, K.E., Binkley, N., Christian, R., Blank, R.B., Vallarta-Ast, N., Krueger, D., Drezner, M.K., & Blank, R.B. (2005). Interobserver reproducibility of criteria for vertebral body exclusion. J. Bone Miner. Res., 20, 501-508.
View publication via DOI: DOI:10.1359/JBMR.041134

Edwards, M.S., Wilson, D.B., Craven, T.E., Stafford, J., Fried, L.F., Wong, T.Y., Klein, R., Burke, G.L., & Hansen, K.J. (2005). Associations between retinal microvascular abnormalities and declining renal function in the elderly: The Cardiovascular Health Study. Am. J. Kidney Dis., 46, 214-224.
View publication via DOI: DOI:10.1053/j.ajkd.2005.05.005

Hansen, K.E., & Elliott, M.E. (2005). Osteoarthritis. In J.T. Dipiro, R.L. Talbert, G.C. Yee, G.R. Matzke, B.G. Wells, & L. Posey, (Eds.), Pharmacotherapy: A pathophysiologic approach (6th ed.). New York: McGraw-Hill.

Hansen, K.E., Vallarta-Ast, N., Krueger, D., Gangnon, R., Drezner, M.K., & Binkley, N. (2004). Use of the lowest vertebral body to diagnose lumbar osteoporosis in men: Is "cherry picking" appropriate? J. Clin. Densitom., 7(4), 376-381.
View publication via DOI: DOI:10.1385/JCD:7:4:376

Binkley, N., Krueger, D., Cowgill, C.S., Plum, L., Lake, E., Hansen, K.E., DeLuca, H.F., & Drezner, M.K. (2004). Assay variation confounds the diagnosis of hypovitaminosis D: A call for standardization. J. Clin. Endocrinol. Metab., 89, 3152-3157.
View publication via DOI: DOI:10.1210/jc.2003-031979

Hansen, K.E., Hildebrand, J., Gangon, R., Genovese, M., Cohen, S., Cush, J., Cooley, D.A., Patel, S.R., & Schiff, M. (2004). The efficacy of switching from etanercept to infliximab in subjects with rheumatoid arthritis. J. Rheumatol., 31(6), 1098-1102.

Kramm, H., Hansen, K.E., Gowing, E., & Bridges, A.J. (2004). Series of rheumatoid arthritis patients treated with retuximab monotherapy. J. Clin. Rheumatol., 10, 1-6.

Hansen, K.E., Cush, J., Singhal, A., Cooley, D.A., Cohen, S., Patel, S.R., Genovese, M., Sundaramurthy, S., & Schiff, M. (2004). The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis. Arthritis Rheum., 51(2), 228-232.

Christian, R., Hansen, K.E., & Elliott, M.E. (2004). Alendronate treatment of transplant recipients in a veteran population. J. Bone Miner. Res., 19(Suppl. 1), SA40.

Hansen, K.E., Drake, R.K., Good, T.R., Cartledge, M.L., & Elliott, M.E. (2003). Efficacy and tolerability of alendronate in veterans with renal insufficiency. J. Bone Miner. Res., 18(Suppl 1), M327.

Hansen, K.E., Kong, D., Moore, K.D., & Ortel, T.L. (2001). Risk factors associated with thrombosis in patients with antiphospholipid antibodies. J. Rheumatol., 28(9), 2018-2024.

Hansen, K.E., Moore, K.D., Ortel, T.L., & Allen, N.B. (1999). Antiphospholipid antibodies in patients with polyarteritis nodosa and Wegener's Granulomatosis. Arthritis and Rheumatism, 42, 2250-2252.
View publication via DOI: DOI:10.1002/1529-0131(199910)42:10<2250::AID-ANR32>3.0.CO;2-7

Hansen, K., Mahoney, J., & Palta, M. (1999). Risk factors for lack of recovery of ADL independence after hospital discharge. J. Am. Geriatr. Soc., 47, 360-365.

Hansen, K.E., Arnason, J., & Bridges, A. (1998). Autoantibodies and common viral illnesses. Semin. Arthritis Rheum., 27, 263-271.
View publication via DOI: DOI:10.1016/S0049-0172(98)80047-4

Hansen, K.E. (1998). Antiphospholipid Antibodies: A review of associated conditions, diagnosis, and treatment. Resident Reporter, 3, 9-14.

Hansen, K.E., & St. Clair, E.W. (1998). Disseminated histoplasmosis in systemic lupus erythematosus: Case report and review of the literature. Semin. Arthritis. Rheum., 28, 193-199.
View publication via DOI: DOI:10.1016/S0049-0172(98)80036-X

Hansen, K.E., Kirkpatrick, S., & Laxova, R. (1995). Dubowitz Syndrome: Long term follow-up of an original patient. Am. J. Med. Gen., 55, 161-164.
View publication via DOI: DOI:10.1002/ajmg.1320550205

Hansen, K.E., & Jefferson, J. (1992). Lithium and arthritis, A review. Lithium, 3, 1-5.

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