Untitled Document

Research

Sterling C. Johnson

Ph.D., Brigham Young University
Associate Professor, Department of Medicine
scj@medicine.wisc.edu
http://www.brainmap.wisc.edu

Functional Imaging in Early Detection of Alzheimer�s Disease

In my lab we use brain imaging in conjunction with neuropsychological measurement to study cognitive disorders of memory and self-awareness. The lab seeks to address questions such as: How early in life does Alzheimer Disease begin and can functional imaging provide new knowledge about presymptomatic disease progression? What are the neural substrates of awareness (or unawareness) of deficit in AD and other cognitive disoders? To answer questions like these we collaborate with a talented multi-disciplinary team, and study healthy volunteers across the age spectrum with and without risk factors for dementia, patients with Alzheimer's disease, Mild Cognitive Impairment, frontal temporal dementias, and patients with traumatic brain injury.

Representative Publications
Bendlin, B.B., Fitzgerald, M.E., Ries, M.L., Xu, G., Kastman, E.K., Thiel, B.W., Rowley, H.A., Lazar, M., Alexander, A.L., & Johnson, S.C. (In Press) White matter in aging and cognition: A cross-sectional study of microstructure in adults aged eighteen to eighty-three. Developmental Neuropsychology.

McLaren, D.G., Kosmatka, K.J., Oakes, T.R., Kroenke, C.D., Kohama, S.G., Matochik, J.A., Ingram D.K., & Johnson, S.C. (2009). A population-average MRI-based atlas collection of the rhesus macaque. Neuroimage, 45(1), 52-59.

Xu, G., McLaren, D.G., Ries, M.L., Fitzgerald, M.E., Bendlin, B.B., Rowley, H.A., Sager, M.A., Atwood, C.S., Asthana, S., & Johnson, S.C. (2009). The influence of parental history of Alzheimer's disease and apolipoprotein E 4 on the BOLD signal during recognition memory. Brain, 132, 383-391.

Colman, R.J., Anderson, R.M., Johnson, S.C., Kastman, E.K., Kosmatka, K.J., T. Beasley, T.M., Allison, D.B., Cruzen, C., Simmons, H.A., Kemnitz, J.W., & Weindruch, R. (2009). Caloric restriction delays disease onset and mortality in rhesus monkeys. Science, 325, 201-204.

Bendlin, B.B., Ries, M.L., Lazar, M., Alexander, A.L., Dempsey, R.J., Rowley, H.A., Sherman, J.E., & Johnson, S.C. (2008). Longitudinal changes in patients with traumatic brain injury assessed with diffusion tensor and volumetric imaging. Neuroimage, 42, 503-51.

Asenath, L.R., Hermann, B., Jones, J., Johnson, S.C., Asthana, S., & Sager, M.A. (2008). Effect of family history of Alzheimer�s disease on serial position profiles. Alzheimer�s and Dementia, 4(4), 285-290.

Haasl, R.J., Reza Ahmadi, M., Vadakkadath Meethal, S., Gleason, C.E., Johnson, S.C., Asthana, S., Bowen, R.L., & Atwood, C.S. (2008). A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer�s disease in males carrying an apolipoprotein E e4 Allele. BMC Medical Genetics, 9(1), 37.

Ries, M.L., Carlsson, C.M., Rowley, H.R., Sager, M.A., Gleason, C.E., Asthana, S., & Johnson, S.C. (2008). MRI characterization of brain structure and function in Mild Cognitive Impairment: A review. Journal of the American Geriatrics Society, 56(5), 920-934.

Xu, G., Fitzgerald, M.E., Wen, Z., Fein, S., Alsop, D., Carroll, T., Ries, M., Rowley, H., Sager, M., Asthana, S., Johnson, S.C., & Carlsson, C.M. (2008). Atorvastatin therapy is associated with greater and faster cerebral hemodynamic response. Brain Imaging and Behavior, 2(2), 94-104.

Johnson, S.C., Schmitz, T.W., Asthana, S., Gluck, M.A., & Myers, C.E. (2008). Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment. Aging, Neuropsychology, and Cognition, 15, 129-14.

Carlsson, C.M., Gleason, C.E., Hess, T.M., Moreland, K.A., Blazel, H.M., Koscik, R.L., Schreiber, N.T.N., Johnson, S.C., Atwood, C.S., Puglielli, L., Hermann, B.P., McBride, P.E., Stein, J.H., Sager, M.A., & Asthana, S. (2008). Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimers disease. Journal of Alzheimers Disease, 13(2), 187-97.

Trivedi, M.A., Schmitz, T.W., Ries, M.L., Hess, T.M., Fitzgerald, M.E., Atwood, C.S., Rowley, H.A., Asthana, S., Sager, M.A., & Johnson, S.C. (2008). fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: Risk factors for Alzheimer's disease. Neuropsychologia, 46(6), 1667-1678.

Humbert, I.A., Fitzgerald, M.E., McLaren, D.G., Johnson, S., Porcaro, E., Kosmatka, K., Hind, J., & Robbins, J. (2008). Neurophysiology of swallowing: Effects of age and bolus type. Neuroimage, 2008, Oct 28. [Epub ahead of print].

Schmitz, T.W., & Johnson, S.C. (2007). Relevance to the self: A brief review and framework of neural systems underlying appraisal. Neuroscience and Biobehavioral Reviews, 31, 585-59.

Johnson, S.C., Ries, M.L., Hess, T.M., Carlsson, C.M., Gleason, C.E., Alexander, A.L., Rowley, H.A., Asthana, S., & Sager, M.A. (2007). Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults. Archives of General Psychiatry, 64(10), 1163-1171.

Ries, M.L., Jabbar, B.M., Schmitz, T.W., Trivedi, M.A., Gleason, C.M., Rowley, H.A., Asthana, S., & Johnson, S.C. (2007). Anosognosia in MCI: Relationship to activation of cortical midline structures involved in self-appraisal. Journal of the International Neuropsychological Society, 13, 450-61.

Wung, J.K., Perry, G., Kowalski, A.., Harris, P.L.R., Bishop, G.M., Trivedi, M.A., Johnson, S.C., Smith, M.A., Denhardt, D.T., & Atwood, C.S. (2007). Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the alzheimer's disease brain. Current Alzheimer Research, 4(1), 67-72.

Trivedi, M.A., Ward, M.A., Hess, T.M., Gale, S.D., Dempsey, R.J., Rowley, H.A., & Johnson, S.C. (2007). Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of coma. Journal of Neurotrauma, 24, 766-77.

Schmitz, T.W., & Johnson, S.C. (2006). Self-appraisal decisions evoke dissociated dorsal�ventral aMPFC networks. Neuroimage, 30(3), 1050-1058.

Trivedi, M.A., Schmitz, T.W., Ries, M.L., Torgerson, B.M., Sager, M.A., Hermann, B.P., Asthana, S., & Johnson, S.C. (2006). Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk for Alzheimer�s Disease: a cross-sectional study. BMC Medicine, 4, 1.

Gleason, C.E., Schmitz, T.W., Hess, T., Koscik, R.L., Trivedi, M.A., Ries, M.L., Carlsson, C.M., Sager, M.A., Asthana, S., & Johnson, S.C. (2006). Hormone effects on fMRI and cognitive measures of encoding: Importance of hormone preparation. Neurology, 67, 2039-204.

Johnson, S.C., Schmitz, T.W., Moritz, C.H., Meyerand, M.E., Rowley, H.A., Alexander, A.L., Hansen, K.W., Gleason, C.E., Carlsson, C.M., Ries, M.L., Asthana, S., Chen, K., Reiman, E.M., & Alexander, G.E. (2006). Activation of brain regions vulnerable to Alzheimer�s disease: The effect of mild cognitive impairment. Neurobiology of Aging, 27, 1604-161.

Johnson, S.C., Schmitz, T.W., Trivedi, M.A., Ries, M.L., Torgerson, B.M., Carlsson, C.M., Asthana, S., Hermann, B.P., & Sager, M.A. (2006). The influence of AD family history and APOE4 on mesial temporal lobe activation. Journal of Neuroscience, 26, 6069-607.

Johnson, S.C., Schmitz, T.W., Rowley, H.A., Alexander, A.L., Lee, J., & Davidson, R.J. (2005). The cerebral response during subjective choice with and without self-reference. J. Cogn. Neurosci., 17(12), 1897-1906.

Ward, M.A., Carlsson, C.M., Trivedi, M.A., Sager, M.A., & Johnson, S.C. (2005). The effect of body mass index on global brain volume in middle-aged adults: A cross-sectional study. BMC Neurol., 5(23), doi:10.1186/1471-2377-5-23.

Gleason, C.E., Cholerton, B., Carlsson, C.M., Johnson, S.C., & Asthana, S. (2005). Neuroprotective effects of female sex steroids in humans: Current controversies and future directions. Cell. Mol. Life Sci., 62(3), 299-312.

Gleason, C.E., Carlsson, C.M., Johnson, S.C., Atwood, C., & Asthana, S. (2005). Clinical pharmacology and differential cognitive efficacy of estrogen preparations. Annals of the New York Academy of Science, 1052, 93-115.

Want to find more Publications? Click here to search the publication database