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Annual
COLLOQUIUM
ON AGING
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IOA Newsletter,
AGING NEWS:

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MIDUS
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Training Grant-
Biology of Aging
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Sterling Johnson

Sterling C. Johnson

Ph.D., Brigham Young University
Professor, Department of Medicine-Geriatrics
scj@medicine.wisc.edu
http://www.brainmap.wisc.edu/people/15-SC-Johnson


Biomarkers for Early Detection of Alzheimer's Disease and Approaches for Secondary Prevention

Dr. Johnson leads the Wisconsin Registry for Alzheimer's Prevention (WRAP), a longitudinal cohort study of 1560 people at varying levels of risk for sporadic AD. He is the Associate Director and Imaging Core Leader in the Wisconsin ADRC. Dr. Johnson is a clinical neuropsychologist with research interests in early identification of Alzheimers Disease and related disorders. He has been NIH funded for 20 years. Current projects focus on A) the WRAP longitudinal study; B) tau and amyloid imaging in people at risk for AD; C) better methods for identifying cognitive decline; D) computer vision and machine learning based multi-modal imaging markers of AD; E) enriching clinical trials and improving trial design with multi-kernel machine learning to speed the discovery of effective treatments for AD.



Representative Publications
Theisen, F., Leda, R., Pozorski, V., Oh, J.M., Adluru, N., Wong, R., Okonkwo, O., Dean, D.C., 3rd, Bendlin, B.B., Johnson, S.C., Alexander, A.L., & Gallagher, C.L. (2018). Evaluation of striatonigral connectivity using probabilistic tractography in Parkinson's disease. NeuroImage: Clinical, 16, 557-563.
View publication via DOI: DOI:10.1016/j.nicl.2017.09.009

Bettcher, B. M., Johnson, S. C., Fitch, R., Casaletto, K. B., Heffernan, K. S., Asthana, S., ... Bendlin, B. B., & Kramer, J. H. (2018). Cerebrospinal fluid and plasma levels of inflammation differentially relate to CNS markers of Alzheimer's disease pathology and neuronal damage. Journal of Alzheimer's Disease, 62(1), 385-397.
View publication via DOI: DOI:10.3233/jad-170602

Clark, L.R., Berman, S.E., Norton, D., Koscik, R.L., Jonaitis, E.M., Blennow, K., Bendlin, B.B., Asthana, S., Johnson, S.C., Zetterberg, H., & Carlsson, C.M. (2018). Age-accelerated cognitive decline in asymptomatic adults with CSF beta-amyloid. Neurology. Advance online publication.
View publication via DOI: DOI:10.1101/220756

Law, L.L., Rol, R.N., Schultz, S.A., Dougherty, R.J., Edwards, D.F., Koscik, R.L., Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., Zetterberg, H., Blennow, K., Asthana, S., Sager, M.A., Hermann, B.P., Johnson, S.C., Cook, D.B., & Okonkwo, O.C. (2018). Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease. Alzheimers & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 188-195.
View publication via DOI: DOI:10.1016/j.dadm.2018.01.001

Zhou, H.H., Singh, V., Johnson, S.C., & Wahba, G. (2018). Statistical tests and identifiability conditions for pooling and analyzing multisite datasets. Proceedings of the National Academy of Sciences, 115(7), 1481-1486.
View publication via DOI: DOI:10.1073/pnas.1719747115

Mueller, K. D., Koscik, R. L., Hermann, B. P., Johnson, S. C., & Turkstra, L. S. (2018). Declines in connected language are associated with very early mild cognitive impairment: Results from the Wisconsin registry for Alzheimer's prevention. Frontiers in Aging Neuroscience, 9, 437.
View publication via DOI: DOI:10.3389/fnagi.2017.00437

Villeneuve, S., Vogel, J. W., Gonneaud, J., Pichet Binette, A., Rosa-Neto, P., Gauthier, S., Fagan, A. M., Bateman, R. J., Morris, J. C., Benzinger, T. L., Johnson, S. C., Breitner, J. C., & Poirier, J (2018). Proximity to parental symptom onset and amyloid-beta burden in sporadic Alzheimer disease. JAMA Neurology. Advance online publication.
View publication via DOI: DOI:10.1001/jamaneurol.2017.5135

Johnson, S. C., Koscik, R. L., Jonaitis, E. M., Clark, L. R., Mueller, K. D., Berman, S. E., Bendlin, B. B., Engelman, C. D., Okonkwo, O. C., Hogan, K. J., Asthana, S., Carlsson, C. M., Hermann, B. P., & Sager, M. A. (2018). The Wisconsin registry for Alzheimer's prevention: A review of findings and current directions. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 130-142.
View publication via DOI: DOI:10.1016/j.dadm.2017.11.007

Gleason, C.E., Norton, D., Anderson, E.D., Wahoske, M., Washington, D.T., Umucu, E., Koscik, R.L., Dowling, N.M., Johnson, S.C., Carlsson, C.M., & Asthana, S. (2018). Cognitive variability predicts incident Alzheimer's disease and mild cognitive impairment comparable to a cerebrospinal fluid biomarker. Journal of Alzheimer's Disease Reports, 61, 79-89.
View publication via DOI: DOI:10.3233/JAD-170498

Dempsey, R.J., Varghese, T., Jackson, D.C., Wang, X., Meshram, N.H., Mitchell, C.C., Hermann, B.P., Johnson, S.C., Berman, S.E., & Wilbrand, S.M. (2018). Carotid atherosclerotic plaque instability and cognition determined by ultrasound-measured plaque strain in asymptomatic patients with significant stenosis. Journal of Neurology, Neurosurgery and Spine, 128, 111-119.
View publication via DOI: DOI:10.3171/2016.10.JNS161299

Zuelsdorff, M.L., Koscik, R.L., Okonkwo, O.C., Peppard, P.E., Hermann, B.P., Sager, M.A., Johnson, S.C., & Engelman, C.D. (2018). Reliability of a novel social activity questionnaire: Perceived social support and verbal interaction in the Wisconsin Registry for Alzheimer's Prevention. Journal of Mental Health and Aging, 30, 305-320.
View publication via DOI: DOI:10.1177/0898264316674812

Mitchell, C.C., Varghese, T., Jackson, D., Meshram, N., Hermann, B.P., Johnson, S.C., Berman, S.E., Wilbrand, S., Dempsey, R.J. (2018). Ultrasound plaque strain determines carotid atherosclerotic plaque instability and cognition in asymptomatic patients with significant stenosis. Journal of Neurosurgery, 128(1), 111-11.
View publication via DOI: DOI:10.3171/2016.10.JNS161299

Vogt, N.M., Kerby, R.L., Dill-McFarland, K.A., Harding, S.J., Merluzzi, A.P., Johnson, S.C., Carlsson, C.M., Asthana, S., Zetterberg, H., Blennow, K., Bendlin, B.B., & Rey, F.E. (2017). Gut microbiome alterations in Alzheimer's disease. Scientific Reports, 7(1), 13537.
View publication via DOI: DOI:10.1038/s41598-017-13601-y

Sprecher, K.E., Koscik, R.L., Carlsson, C.M., Zetterberg, C.M., Blennow, K., Okonkwo, O.C., Sager, M.A., Asthana, S., Johnson, S.C., Benca, R.M., & Bendlin, B.B. (2017). Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults. American Academy of Neurology 89(5), 445-453.
View publication via DOI: DOI:10.1212/WNL.0000000000004171

Johnson, S.C., Koscik, R.L., Jonaitis, E.M., Clark, L.R., Mueller, K.D., Berman, S.E., Bendlin, B.B., Engelman, C.D., Okonkwo, O.C., Hogan, K.J., Asthana, S., Carlsson, C.M., Hermann, B.P., & Sager, M.A. (2017). The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions. Alzheimer's & Dementia, 10, 130-142.
View publication via DOI: DOI:10.1101/206839

Vogt, N.M., Kerby, R.L., Dill-McFarland, K.A., Harding, S.J., Merluzzi, A.P., Johnson, S.C., Carlsson, C.M., Asthana, S., Zetterberg, H., Blennow, K., Bendlin, B.B., & Rey, F.E. (2017). Gut microbiome alterations in Alzheimer's disease. Scientific Reports, 7(1), 13537.
View publication via DOI: DOI:10.1038/s41598-017-13601-y

Willette, A.A., Webb, J.L., Lutz, M.W., Bendlin, B.B., Wennberg, A.M., Oh, J.M., Roses, A., Koscik, R.L., Hermann, B.P., Dowling, N.M., Asthana, S., Johnson, S.C., & Alzheimer's Disease Neuroimaging Initiative. (2017). Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts. Alzheimer's & Dementia, 13(11), 1217-1225.
View publication via DOI: DOI:10.1016/j.jalz.2017.03.009

Boots, E.A., Schultz, S.A., Clark, L.R., Racine, A.M., Darst, B.F., Koscik, R.L., Carlsson, C.M., Gallagher, C.L., Hogan, K.J., Bendlin, B.B., Asthana, S., Sager, M.A., Hermann, B.P., Christian, B.T., Dubal, D.B., Engelman, C.D., Johnson, S.C., & Okonkwo, (2017). BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention. American Academy of Neurology, 88(22), 2098-2106.
View publication via DOI: DOI:10.1212/WNL.0000000000003980

Berman, S.E., Clark, L.R., Rivera-Rivera, L.A., Norton, D., Racine, A.M., Rowley, H.A., Bendlin, B.B., Blennow, K., Zetterberg, H., Carlsson, C.M., Asthana, S., Turski, P., Wieben, O., & Johnson, S.C. (2017). Intracranial arterial 4D flow in individuals with mild cognitive impairment is associated with cognitive performance and amyloid positivity. Journal of Alzheimer's Disease Reports, 60(1), 243-252.
View publication via DOI: DOI:10.3233/JAD-170402

Racine, A.M., Merluzzi, A.P., Adluru, N., Norton, D., Koscik, R.L., Clark, L., Berman, S.E., Nicholas, C.R., Asthana, S., Alexander, A.L., Blennow, K., Zetterberg, H., Kim, W.H., Singh, V., Carlsson, C.M., Bendlin, B.B., & Johnson, S.C. (2017). Association of longitudinal white matter degeneration and cerebrospinal fluid biomarkers of neurodegeneration, inflammation and Alzheimer's disease in late-middle-aged adults. Brain Imaging and Behavior. Advance online publication.
View publication via DOI: DOI:10.1007/s11682-017-9732-9

Hoy, A.R., Ly, M., Carlsson, C.M., Okonkwo, O.C., Zetterberg, H., Blennow, K., Sager, M.A., Asthana, S., Johnson, S.C., Alexander, A.L., & Bendlin, B.B. (2017). Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging. PLoS One, 12(3), e0173982.
View publication via DOI: DOI:10.1371/journal.pone.0173982

Casaletto, K.B., Elahi, F.M., Bettcher, B.M., Neuhaus, J., Bendlin, B.B., Asthana, S., Johnson, S.C., Yaffe, K., Carlsson, C., Blennow, K., Zetterberg, H., & Kramer, J.H. (2017). Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers. American Academy of Neurology, 89(17), 1782-1788.
View publication via DOI: DOI:10.1212/WNL.0000000000004569

Berman, S. E., Clark, L. R., Rivera-Rivera, L. A., Norton, D., Racine, A. M., Rowley, H. A., Bendlin, B. B., ... Carlsson, C. M., Asthana, S., ... Johnson, S. C. (2017). Intracranial arterial 4D flow in individuals with mild cognitive impairment is associated with cognitive performance and amyloid positivity. Journal of Alzheimer's Disease, 60(1), 243-252.
View publication via DOI: DOI:10.3233/jad-170402

Hoscheidt, S. M., Kellawan, J. M., Berman, S. E., Rivera-Rivera L., A., Krause, R. A. Oh, J. M., . . . Asthana, S., Johnson, S. C., Schrage, W. G., & Bendlin, B. B. (2017). Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults. Journal of Cerebral Blood Flow and Metabolism, 37(6), 2249-2261.
View publication via DOI: DOI:10.1177/0271678X16663214

Law, L. L., Schultz, S. A., Boots, E. A., Einerson, J. A., Dougherty, R. J., Oh, J. M., Korcarz, C. E., Edwards, D. F., ... Bendlin, B. B., Carlsson, C. M., Asthana, S., Hermann, B. P., Sager, M. A., Johnson, S. C., ... & Okonkwo, O. C. (2017). Chronotropic response and cognitive function in a cohort at risk for Alzheimer's disease. Journal of Alzheimer's Disease, 56(1), 351-359.
View publication via DOI: DOI:10.3233/jad-160642

Dean, D. C. I., Hurley, S. A., Kecskemeti, S. R., O'Grady, P., Canda, C., Davenport-Sis, N. J., ... Asthana, S., Sager, M. A., Johnson, S. C., Alexander, A., & Bendlin, B. B. (2017). Association of amyloid pathology with myelin alteration in preclinical Alzheimer's disease. JAMA Neurology, 74(1), 41-49.
View publication via DOI: DOI:10.1001/jamaneurol.2016.3232

Clark, L. R., Berman, S. E., Rivera-Rivera, L. A., Hoscheidt, S. M., Darst, B. F., Engelman, C. D., ... Asthana, S., Turski, P., Wieben, O., & Johnson, S. C. (2017). Macrovascular and microvascular cerebral blood flow in adults at risk for Alzheimer's disease. Alzheimer's & Dementia, 7, 48-55.
View publication via DOI: DOI:10.1016/j.dadm.2017.01.002

Dougherty, R. J., Schultz, S. A., Boots, E. A., Ellingson, L. D., Meyer, J. D., Van Riper, S., Stegner, A. J., Edwards, D. F., ... Bendlin, B. B., Asthana, S., ... Sager, M. A., ... Johnson, S. C., Okonkwo, O. C., & Cook, D. B. (2017). Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease. Brain and Behavior, 7(3), e00625.
View publication via DOI: DOI:10.1002/brb3.625

Rivera-Rivera, L. A., Schubert, T., Turski, P., Johnson, K. M., Berman, S. E., Rowley, H. A., Carlsson, C. M., Johnson, S. C., & Wieben, O. (2017). Changes in intracranial venous blood flow and pulsatility in Alzheimer's disease: A 4D flow MRI study. Journal of Cerebral Blood Flow and Metabolism, 37(6), 2149-2158.
View publication via DOI: DOI:10.1177/0271678x16661340

Clark, L. R., Koscik, R. L., Nicholas, C. R., Okonkwo, O. C., Engelman, C. D., Bratzke, L. C., ... Bendlin, B. B., Carlsson, C. M., Asthana, S., Sager, M. A., ... Johnson, S. C. (2017). Changes in intracranial venous blood flow and pulsatility in Alzheimer's disease: A 4D flow MRI study. Archives of Clinical Neuropsychology, 37(6), 2149-2158.
View publication via DOI: DOI:10.1093/arclin/acw024

Darst, B. F., Koscik, R. L., Racine, A. M., Oh, J. M., Krause, R. A., Carlsson, C. M., ... Bendlin, B. B., Okonkwo, O. C., ... Sager, M. A., Asthana, S., Johnson, S. C., & Engelman, C. D. (2017). Pathway-specific polygenic risk scores as predictors of amyloid-beta deposition and cognitive function in a sample at increased risk for Alzheimer's disease. Journal of Alzheimer's Disease, 55(2), 473-484.
View publication via DOI: DOI:10.3233/jad-160195

Engelman, C.D., Darst, B.F., Bilgel, M., Vasiljevic, E., Koscik, R.L., Jedynak, B.M., & Johnson, S.C. (2017). The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer's prevention. Neurobiology of Aging. Advance online publication.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2017.12.025

Zuelsdorff, M. L., Koscik, R. L., Okonkwo, O. C., Peppard, P. E., Hermann, B. P., Sager, M. A., Johnson, S. C., & Engelman, C. D. (2017). Social support and verbal interaction are differentially associated with cognitive function in midlife and older age. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition. Advance online publication.
View publication via DOI: DOI:10.1080/13825585.2017.1414769

Mueller, K.D., Koscik, R.L., Clark, L.R., Hermann, B.P., Johnson, S.C., & Turkstra, L.S. (2017). The latent structure and test-retest stability of connected language measures in the Wisconsin Registry for Alzheimer's Prevention (WRAP). Archives of Clinical Neuropsychology. Advance online publication.
View publication via DOI: DOI:10.1093/arclin/acx116

Betthauser, T.J., Ellison, P.A., Murali, D., Lao, P.J., Barnhart, T.E., Furumoto, S., Okamura, N., Johnson, S.C., Engle, J.W., Nickles, R.J., & Christian, B.T. (2017). Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau. Applied Radiation and Isotopes, 130, 230-237.
View publication via DOI: DOI:10.1016/j.apradiso.2017.10.002

Casaletto, K.B., Elahi, F.M., Bettcher, B.M., Neuhaus, J., Bendlin, B.B., Asthana, S., Johnson, S.C., Yaffe, K., Carlsson, C., Blennow, K., Zetterberg, H., & Kramer, J.H. (2017). Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers. Neurology, 89, 1782-1788.
View publication via DOI: DOI:10.1212/WNL.0000000000004569

Berman, S.E., Clark, L.R., Rivera-Rivera, L.A., Norton, D., Racine, A.M., Rowley, H.A., Bendlin, B.B., Blennow, K., Zetterberg, H., Carlsson, C.M., Asthana, S., Turski, P., Wieben, O., & Johnson, S.C. (2017). Intracranial arterial 4D flow in individuals with mild cognitive impairment is associated with cognitive performance and amyloid positivity. Journal of Alzheimer's Disease Reports, 60, 243-252.
View publication via DOI: DOI:10.3233/JAD-170402

Mihaila, I., Hartley, S.L., Handen, B.L., Bulova, P.D., Tumuluru, R.V., Devenny, D.A., Johnson, S.C., Lao, P.J., & Christian, B.T. (2017). Leisure activity and caregiver involvement in middle-aged and older adults with Down syndrome. American Journal on Intellectual and Developmental Disabilities, 55(2), 97-109.
View publication via DOI: DOI:10.1352/1934-9556-55.2.97

Gutierrez-Barragan, F., Ithapu, V.K., Hinrichs, C., Maumet, C., Johnson, S.C., Nichols, T.E., Singh, V., & Alzheimer's Disease Neuroimaging Initiative. (2017). Accelerating permutation testing in voxel-wise analysis through subspace tracking: A new plugin for SnPM. Neuroimage, 159, 79-98 .
View publication via DOI: DOI:10.1016/j.neuroimage.2017.07.025

Betthauser, T.J., Lao, P.J., Murali, D., Barnhart, T.E., Furumoto, S., Okamura, N., Stone, C.K., Johnson, S.C., & Christian, B.T. (2017). In vivo comparison of Tau Radioligands (18)F-THK-5351 and (18)F-THK-5317. American Journal of Nuclear Medicine and Molecular Imaging, 58(6), 996-1002.
View publication via DOI: DOI:10.2967/jnumed.116.182980

Willette, A.A., Webb, J.L., Lutz, M.W., Bendlin, B.B., Wennberg, A.M., Oh, J.M., Roses, A., Koscik, R.L., Hermann, B.P., Dowling, N.M., Asthana, S., Johnson, S.C., & Alzheimer's Disease Neuroimaging Initiative (2017). Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts. Alzheimer's, Dementia and Cognitive Neurology, 13, 1217-1225.
View publication via DOI: DOI:10.1016/j.jalz.2017.03.009

Neu, S.C., Pa, J., Kukull, W., Beekly, D., Kuzma, A., Gangadharan, P., Wang, L.S., Romero, K., Arneric, S.P., Redolfi, A., Orlandi, D., Frisoni, G.B., Au, R., Devine, S., Auerbach, S., Espinosa, A., Boada, M., Ruiz, A., Johnson, S.C., Koscik, R., Wang, J. (2017). Apolipoprotein E genotype and sex risk factors for Alzheimer Disease: A meta-analysis. Journal of the American Medical Association Neurology, 74(10), 1178-1189.
View publication via DOI: DOI:10.1001/jamaneurol.2017.2188

Racine, A.M., Merluzzi, A.P., Adluru, N., Norton, D., Koscik, R.L., Clark, L.R., Berman, S.E., Nicholas, C.R., Asthana, S., Alexander, A.L., Blennow, K., Zetterberg, H., Kim, W.H., Singh, V., Carlsson, C.M., Bendlin, B.B., & Johnson, S.C. (2017). Association of longitudinal white matter degeneration and cerebrospinal fluid biomarkers of neurodegeneration, inflammation and Alzheimer's disease in late-middle-aged adults. Brain Imaging and Behavior. Advance online publication.
View publication via DOI: DOI:10.1007/s11682-017-9732-9

Bilgel, M., Koscik, R.L., An, Y., Prince, J.L., Resnick, S.M., Johnson, S.C., & Jedynak, B.M. (2017). Temporal order of Alzheimer's disease-related cognitive marker changes in BLSA and WRAP longitudinal studies. Journal of Alzheimer's Disease Reports, 59(4), 1335-1347.
View publication via DOI: DOI:10.3233/JAD-170448

Gross, A.L., Hassenstab, J., Johnson, S., Clark, L.R., Resnick, S.M., Kitner-Triolo, M., Masters, C., Maruff, P., Morris, J.C., Soldan, A., Pettigrew, C., & Albert, M. (2017). A classification algorithm for predicting progression from normal cognition to mild cognitive impairment across five cohorts: The preclinical AD consortium. Alzheimer's and Dementia, 8, 147-155..
View publication via DOI: DOI:10.1016/j.dadm.2017.05.003

Nicholas, C.R., Dowling, N.M., Racine, A.M., Clark, L.R., Berman, S.E., Koscik, R.L., Asthana, S., Hermann, B.P., Sager, M.A., & Johnson, S.C. (2017). Longitudinal assessment of self and informant subjective cognitive complaints in a sample of healthy late-middle aged adults enriched with a family history of Alzheimer's disease. Journal of the International Neuropsychological Society, 23(8), 617-626.
View publication via DOI: DOI:10.1017/S1355617717000509

Dougherty, R.J., Schultz, S.A., Kirby, T.K., Boots, E.A., Oh, J.M., Edwards, D.F., Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., Asthana, S., Sager, M.A., Hermann, B.P., Christian, B.T., Johnson, S.C., Cook, D.B., & Okonkwo, O.C. (2017). Moderate physical activity is associated with cerebral glucose metabolism in adults at risk for Alzheimer's Disease Journal of Alzheimer's Disease, 58, 1089-1097.
View publication via DOI: DOI:10.3233/JAD-161067

Sprecher, K.E., Koscik, R.L., Carlsson, C.M., Zetterberg, H., Blennow, K., Okonkwo, O., Sager, M.A., Asthana, S., Johnson, S.C., Benca, R.M., & Bendlin, B.B. (2017). Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults. Neurology. 89, 445-453.
View publication via DOI: DOI:10.1212/WNL.0000000000004171

Berman, S.E., Koscik, R.L., Clark, L.R., Mueller, K.D., Bluder, L., Galvin, J.E., & Johnson, S.C. (2017). Use of the Quick Dementia Rating System (QDRS) as an initial screening measure in a longitudinal cohort at risk for Alzheimer's Disease. Journal of Alzheimer's Disease-Reports, 1, 9-13.
View publication via DOI: DOI:10.3233/ADR-170004

Schultz, S.A., Boots, E., Darst, B., Zetterberg, H., Blennow, K., Edwards, D.F., Koscik, R.L., Carlsson, C.M., Gallagher, C.L., Bendlin, B.B., Asthana, S., Sager, M.A., Hogan, K., Hermann, B.P., Cook, D., Johnson, S.C., Engelman, C., & Okonkwo, O.C. (2017). Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD. Neurology, 88, 1650-1658.
View publication via DOI: DOI:10.1212/WNL.0000000000003862.

Hartley, S., Handen, B.L., Devenny, D., Mihaila, I., Hardison, R., Lao, P.J., Klunk, W.E., Bulova, P., Johnson, S.C., & Christian, B.T. (2017). Cognitive decline and brain amyloid-beta accumulation across 3-years in adults with Down syndrome. Neurobiology of Aging, 58, 68-76.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2017.05.019

Nicholas, C.R., Hoscheidt, S.M., Clark, L.R., Racine, A.M., Berman, S.E., Koscik, R.L., Dowling, N.M., Asthana, S., Christian, B.T., Sager, M.A., & Johnson, S.C. (2017). Positive affect predicts cerebral glucose metabolism in late middle-aged adults. Social Cognitive and Affective Neuroscience, 12(6), 993 -1000.
View publication via DOI: DOI:10.1093/scan/nsx027

Hoy, A.R., Ly, M., Carlsson, C.M., Okonkwo, O.C., Zetterberg, H., Blennow, K., Sager, M.A., Asthana, S., Johnson, S.C., Alexander, A.L., & Bendlin, B.B. (2017). Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging. PLoS One, 12(3), e0173982.
View publication via DOI: DOI:10.1371/journal.pone.0173982

Dempsey, R.J., Jackson, D., Wilbrand, S., Mitchell, C.C., Berman, S.E., Johnson, S.C., Varghese, T., & Hermann, B.P. (2017). The preservation of cognition one year after carotid endarterectomy in patients with prior cognitive decline Journal of Neurosurgery, 82(3), 322-328.
View publication via DOI: DOI:10.1093/neuros/nyx173

Lao, P.J., Handen, B.L., Betthauser, T.J., Mihaila, I., Hartley, S.L., Cohen, A.D., ... Mailick, M.R., Klunk, W.E., Johnson, S.C., & Christian, B.T. (2017). Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 9, 1-9.
View publication via DOI: DOI:10.1016/j.dadm.2017.05.001

Boots, E. A., Schultz, S. A., Clark, L. R., Racine, A. M., Darst, B. F., Koscik, R. L., Carlsson, C. M., ... Bendlin, B. B., Asthana, S., Sager, M. A., ... Engelman, C. D., Johnson, S. C., & Okonkwo, O. C. (2017). BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's prevention. Neurology, 88(22), 2098-2106.
View publication via DOI: DOI:10.1212/wnl.0000000000003980

Martin, S.A., DeMuth, T.M., Miller, K.N., Pugh, T.D., Polewski, M.A., Colman, R.J., Eliceiri, K.W., Beasley, T.M., Johnson, S.C., & Anderson, R.M. (2016). Regional metabolic heterogeneity of the hippocampus is non-uniformly impacted by age and caloric restriction. Aging Cell, 15: 100.
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Clark, L. R., Racine, A. M., Koscik, R. L., Okonkwo, O. C., Engelman, C. D., Carlsson, C. M., Asthana, S., Bendlin, B. B., ... Sager, M. A., Christian, B. T., & Johnson, S. C. (2016). Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin registry for Alzheimer's prevention study. Alzheimer's & Dementia, 12(7), 805-814.
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Ly, M., Adluru, N., Destiche, D.J., Lu, S.Y., Oh, J.M., Hoscheidt, S.M., Alexander, A.L., Okonkwo, O.C., Rowley, H.A., Sager, M.A., Johnson, S.C., & Bendlin, B.B. (2016). Fornix microstructure and memory performance is associated with altered neural connectivity during episodic recognition. Journal of the International Neuropsychological Society, 22(2), 191-204.
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Melah, K. E., Lu, S. Y., Hoscheidt, S. M., Alexander, A. L., Adluru, N., Destiche, D. J., ... Okonkwo, O. C., ... Sager, M. A., Asthana, S., Johnson, S. C., & Bendlin, B. B. (2016). Cerebrospinal fluid markers of Alzheimer's disease pathology and microglial activation are associated with altered White matter microstructure in asymptomatic adults at risk for Alzheimer's disease. Journal of Alzheimer's Disease, 50(3), 873-886.
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Koscik, R. L., Berman, S. E., Clark, L. R., Mueller, K. D., Okonkwo, O. C., Gleason, C. E., Hermann, B. P., Sager, M. A., & Johnson, S. C. (2016). Intraindividual cognitive variability in middle age predicts cognitive impairment 8-10 years later: Results from the Wisconsin registry for Alzheimer's prevention. Journal of the International Neuropsychological Society, 22(10), 1016-1025.
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Racine, A. M., Clark, L. R., Berman, S. E., Koscik, R. L., Mueller, K. D., Norton, D., ... Asthana, S., & Johnson, S. C. (2016). Associations between performance on an abbreviated cogstate battery, other measures of cognitive function, and biomarkers in people at risk for Alzheimer's disease. Journal of Alzheimer's Disease 54(4), 1395-1408.
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Dean, D. C., 3rd, Sojkova, J., Hurley, S., Kecskemeti, S., Okonkwo, O., Bendlin, B. B., Theisen, F., Johnson, S. C., Alexander, A. L., & Gallagher, C. L. (2016). Alterations of myelin content in Parkinson's disease: A cross-sectional neuroimaging study. PLoS One, 11(10), e0163774.
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Mueller, K. D., Koscik, R. L., Turkstra, L. S., Riedeman, S. K., LaRue, A., Clark, L. R., Hermann, B., Sager, M. A., & Johnson, S. C. (2016). Connected language in late middle-aged adults at risk for Alzheimer's disease. Journal of Alzheimer's Disease 54(4), 1539-1550.
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Merluzzi, A. P., Dean, D. C., 3rd, Adluru, N., Suryawanshi, G. S., Okonkwo, O. C., Oh, J. M., Hermann, B. P., Sager, M. A., Asthana, S., Zhang, H., Johnson, S. C., Alexander, A. L., & Bendlin, B. B. (2016). Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging. Neurobiology of Aging, 43, 79-88.
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Racine, A. M., Koscik, R. L., Berman, S. E., Nicholas, C. R., Clark, L. R., Okonkwo, O. C., Rowley, H. A., Asthana, S., Bendlin, B. B., ... & Johnson, S. C. (2016). Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife. Brain, 139(Pt 8), 2261-2274.
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Livny, A., Ravona-Springer, R., Heymann, A., Priess, R., Kushnir, T., Tsarfaty, G., ... Johnson, S. C., Bendlin, B. B., & Schnaider Beeri, M. (2016). Long-term variability in glycemic control is associated with White matter hyperintensities in apoe4 genotype carriers with type 2 diabetes. Diabetes Care, 39(6), 1056-1059.
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Hoscheidt, S. M., Starks, E. J., Oh, J. M., Zetterberg, H., Blennow, K., Krause, R. A., ... Puglielli, L., Atwood, C. S., ... Asthana, S., Johnson, S. C., & Bendlin, B. B. (2016). Insulin resistance is associated with increased levels of cerebrospinal fluid biomarkers of Alzheimer's disease and reduced memory function in at-risk healthy middle-aged adults. Journal of Alzheimer's Disease, 52(4), 1373-1383.
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Dougherty, R. J., Ellingson, L. D., Schultz, S. A., Boots, E. A., Meyer, J. D., Lindheimer, J. B., ... Edwards, D. F., ... Bendlin, B. B., Asthana, S., ... Sager, M. A., Johnson, S. C., Okonkwo, O. C., & Cook, D. B. (2016). Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease. Alzheimer's & Dementia, 4, 14-17.
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Racine, A. M., Koscik, R. L., Nicholas, C. R., Clark, L. R., Okonkwo, O. C., Oh, J. M., ... Asthana, S., Bendlin, B. B., Blennow, K., Zetterberg, H., Carlsson, C. M., Christian, B. T., & Johnson, S. C. (2016). Cerebrospinal fluid ratios with abeta42 predict preclinical brain beta-amyloid accumulation. Alzheimer's & Dementia, 2, 27-38.
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Nicholas, C.P., Okonkwo, O.C., Bendlin, B.B., Oh, J.M., Asthana, S., Rowley, H.A., Hermann, B., Sager, M.A., Johnson, S.C. (2015). Posteromedial hyperactivation during episodic recognition among people with memory decline: Findings from the WRAP Study. Brain Imaging and Behavior, 9(4), 690-702.
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Almeida, R.P., Schultz, S.A., Austin, B.P., Boots, E.A., Dowling, N.M., Gleason, C.E., Bendlin, B.B., Sager, M.A., Hermann, B.P., Zetterberg, H., Carlsson, C.M., Johnson, S.C., Asthana, S., & Okonkwo, O.C. (2015). Effect of cognitive reserve on age-related changes in cerebrospinal fluid biomarkers of Alzheimer Disease. JAMA Neurology, 72(6), 699-706.
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Schultz, S.A., Oh, J.M., Koscik, R.L., Dowling, N.M., Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Rowley, H.A., Asthana, S., Sager, M.A., Johnson, S.C., & Okonkwo, O.C (2015). Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle-aged adults at risk for AD. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(1), 33-40.
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Darst, B. F., Koscik, R. L., Hermann, B. P., La Rue, A., Sager, M. A., Johnson, S. C., & Engelman, C. D. (2015). Heritability of cognitive traits among siblings with a parental history of Alzheimer's disease. Journal of Alzheimer's Disease, 45(4), 1149-1155.
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Berman, S.E., Rivera, L.A., Clark, L.R., Racine, A.M., Carlsson, C.M., Bendlin, B.B., Bratzke, L.C., Rowley, H., Turski, P., Zetterberg, H., Blennow, K., Asthana, S., Johnson, S.C., & Wieben, O. (2015). Intracranial arterial 4D-Flow is associated with metrics of brain health and Alzheimer's disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 1(4), 420-428.
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Willette, A.A., Bendlin, B.B., Starks, E.J., Birdsill, A.C., Johnson, S.C., Christian, B., Okonkwo, O.C., LaRue, A., Hermann, B., Koscik, R., Jonaitis, E., Sager, M.A., & Asthana, S. (2015). Insulin resistance is associated with lower cerebral glucose uptake in middle-aged adults. JAMA Neurology, 72(9), 1013-1020.
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Starks, E.J., O'Grady, P., Hoscheidt, S.M., Racine, A.M., Carlsson, C.M., Zetterberg, H., ... Okonkwo, O.C., Puglielli, L., Asthana, S., ... Anderson, R., ... Sager, M.A., Johnson, S.C., Bendlin, B.B. (2015). Insulin resistance is associated with higher cerebrospinal fluid tau levels in asymptomatic APOE Ε4 carriers. Journal of Alzheimer's Disease, 46(2), 525-33.
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Sprecher, K.E., Bendlin, B.B., Racine, A.M., Okonkwo, O.C., Christian, B.T., Koscik, R., Sager, M.A., Asthana, S., Johnson, S.C., & Benca, R.M. (2015). Amyloid Imaging Is Associated With Self-Reported Sleep In Cognitively Healthy Late Middle-Aged Adults. Neurobiology of Aging, 36(9), 2568-76.
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Kim, W.H., Adluru, N., Chung, M.K., Okonkwo, O.C., Johnson, S.C., Bendlin, B.B., & Singh, V. (2015). Multi-resolution statistical analysis of brain connectivity graphs in preclinical Alzheimer's disease. Neuroimage, 118, 103-17.
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Schultz, S.A., Larson, J., Oh, J., Koscik, R., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Hermann, B.P., Johnson, S.C., Sager, M., LaRue, A., & Okonkwo, O.C. (2015). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease. Brain Imaging & Behavior, 9(4), 729-36.
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Boots, E.A., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., ... Johnson, S.C., & Okonkwo, O.C. (2015). Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease. Brain Imaging & Behavior, 9(3), 639-49.
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Boots, E.A., Schultz, S.A., Almeida, R.P., Oh, J.M., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Sager, M.A., Hermann, B.P., Johnson, S.C., & Okonkwo, O.C. (2015). Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease. Archives of Clinical Neuropsychology, 30(7), 634-42.
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Willette, A. A., Bendlin, B. B., Starks, E. J., Birdsill, A. C., Johnson, S. C., Christian, B. T., Okonkwo, O. C ... Sager, M. A., & Asthana, S. (2015). Association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for Alzheimer disease. JAMA Neurology, 72(9), 1013-1020.
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Doherty, B. M., Schultz, S. A., Oh, J. M., Koscik, R. L., Dowling, N. M., Barnhart, T. E., ... Bendlin, B. B., Asthana, S., Sager, M. A., ... Johnson, S. C., & Okonkwo, O. C. (2015). Amyloid burden, cortical thickness, and cognitive function in the Wisconsin registry for Alzheimer's prevention. Alzheimer's & Dementia, 1(2), 160-169.
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Koscik, R. L., La, R. A., Jonaitis, E. M., Okonkwo, O. C., Johnson, S. C., Bendlin, B. B., Hermann, B. P., & Sager, M.A. (2014). Emergence of mild cognitive impairment in late-middle-aged adults in the Wisconsin Registry for Alzheimer's Prevention. Dementia and Geriatric Cognitive Disorders, 38(1-2), 16-30.
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Johnson, S. C., Christian, B. T., Okonkwo, O. C., Oh, J. M., Harding, S., Xu, G., . . . Bendlin, B. B., . . . Asthana, S., & Sager, M. A. (2014). Amyloid burden and neural function in people at risk for Alzheimer's disease. Neurobiology of Aging, 35(3), 576-584.
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Birdsill, A. C., Koscik, R. L., Jonaitis, E. M., Johnson, S. C., Okonkwo, O. C., Hermann, B. P., . . . Sager, M. A., & Bendlin, B. B. (2014). Regional white matter hyperintensities: Aging, Alzheimer's disease risk, and cognitive function. Neurobiology of Aging, 35(4), 769-776.
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Ly, M., Canu, E., Xu, G., Oh, J., McLaren, D. G., Dowling, N. M., ... Sager, M. A., Johnson, S. C., & Bendlin, B. B. (2014). Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults. Human Brain Mapping, 35(5), 2044-2054.
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Okonkwo, O.C., Oh, J.M., Koscik, R., Jonaitis, E., Cleary, C.A., Dowling, N.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Barnhart, T.E., Murali, D., Rowley, H.A., Carlsson, C.M., Gallagher, C.L., Asthana, S., Sager, M.A., Christian, B.T., & Johnson, S.C. (2014). Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. Journal of the International Neuropsychological Society, 20(4), 422-433.
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Kim, W.H., Singh, V., Chung, M.K., Hinrichs, C., Pachauri, D., Okonkwo, O.C., & Johnson, S.C. (2014). Multi-resolutional shape features via non-Euclidean wavelets: Applications to statistical analysis of cortical thickness. NeuroImage, 93(Pt 1), 107-123.
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Adluru, N., Destiche, D.J., Lu, S., Doran, S.T., Birdsill, A.C., Melah, K.E., Okonkwo, O.C., Alexander, A.L., Dowling, N.M., Johnson, S.C., Sager, M.A., & Bendlin, B.B. (2014). White matter microstructure in late middle-age: Effects of Apolipoprotein E4 and parental family history of Alzheimer's disease. NeuroImage: Clinical, 4, 730-742.
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Ithapu, V., Singh, V., Okonkwo, O.C., & Johnson, S.C (2014). Randomized denoising autoencoders for smaller and efficient imaging based AD clinical trials. Medical Image Computing and Computer-Assisted Intervention, 17(Pt 2), 470-8.

Okonkwo, O.C., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R., Gallagher, C.L., Dowling, N.M., Carlsson, C.M., Bendlin, B.B., LaRue, A., Rowley, H.A., Christian, B.T., Asthana, S., Hermann, B.P., Johnson, S.C., & Sager, M.A. (2014). Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology, 83(19), 1753-1760.
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Boots, E.A., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., LaRue, A., Asthana, S., Hermann, B.P., Sager, M.A., Johnson, S.C., & Okonkwo, O.C. (2014). Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease. Alzheimer's & Dementia, 10(4), p165.
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Gallagher, C.L., Bell, B., Palotti, M., Oh, J., Christian, B.T., Okonkwo, O., Sojkova, J., Buyan-Dent, L., Nickles, R.J., Harding, S.J., Stone, C.K., Johnson, S.C., & Holden, J.E. (2014). Anterior cingulate dopamine turnover and behavior change in Parkinson's disease. Brain Imaging and Behavior, 9(4), 821-827.
View publication via DOI: DOI:10.1007/s11682-014-9338-4

Colman, R.J., Beasley, T.M., Kemnitz, J.W., Johnson, S.C., Weindruch, R., & Anderson, R.M. (2014). Caloric restriction increases age-related and all cause survival in rhesus monkeys. Nature Communications 5, 3557.
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Willette, A. A., Johnson, S. C., Birdsill, A. C., Sager, M. A., Christian, B., Baker, L. D., Craft, S., Oh, J., Statz, E., Hermann, B. P., Jonaitis, E. M., Koscik, R. L., La Rue, A., Asthana, S., & Bendlin, B. B. (2014). Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimer's & Dementia, 11(5), 504-510.e1.
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Okonkwo, O. C., Xu, G., Oh, J. M., Dowling, N. M., Carlsson, C. M., Gallagher, C. L., Birdsill, A. C., Palotti, M., Wharton, W., Hermann, B. P., LaRue, A., Bendlin, B. B., Rowley, H. A., Asthana, S., Sager, M. A., & Johnson, S. C. (2014). Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease. Cerebral Cortex, 24(4), 978-988.
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Mielke, M.M., Haughey, N.J., Bandaru, V.V., Zetterberg, H., Blennow, K., Andreasson, U., Johnson, S.C., Gleason, C.E., Blazel, H.M., Puglielli, L., Sager, M.A., Asthana, S., & Carlsson, C.M. (2014). Cerebrospinal fluid sphingolipids, beta-amyloid, and tau in adults at risk for Alzheimer's disease. Neurobiological Aging, 35(11), 2486-2494.
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Hartley, S.L., Handen, B.L., Devenny, D.A., Hardison, R., Mihaila, I., Price, J.C., Cohen, A.D., Klunk, W.E., Mailick, M.R., Johnson, S.C., Christian, B.T. (2014). Cognitive functioning in relation to brain amyloid-? in healthy adults with Down syndrome. Brain, 137(Pt 9), 2556-63.
View publication via DOI: DOI:10.1093/brain/awu173

Sridharan, A., Bendlin, B. B., Gallagher, C. L., Oh, J. M., Willette, A. A., Alexander, A. L., Kemnitz, J. W., Colman, R. J., Weindruch, R. H., & Johnson, S. C. (2014). Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: A fiber tractography study. Neuroscience Letters, 569, 38-42.
View publication via DOI: DOI:10.1016/j.neulet.2014.03.047

Birdsill, A. C., Carlsson, C. M., Willette, A. W., Okonkwo, O. C., Johnson, S. C., Xu, G., ... Asthana, S., Sager, M. A., & Bendlin, B. B. (2013). Low cerebral blood flow is associated with lower memory function in metabolic syndrome. Obesity, 21(7), 1313-1320.
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Sridharan, A., Pehar, M., Salamat, M. S., Pugh, T. D., Bendlin, B. B., Willette, A. A., Anderson, R. M., Kemnitz, J. W., . . . Weindruch, R., Puglielli, L., & Johnson, S. C. (2013). Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: A preliminary quantitative imaging study. Brain Research, 1508, 1-8.
View publication via DOI: DOI:10.1016/j.brainres.2013.02.046

Willette, A. A., Coe, C. L., Birdsill, A. C., Bendlin, B. B., Colman, R. J., Alexander, A. L., ... Weindruch, R. H., & Johnson, S. C. (2013). Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age, 35(6), 2215-2227.
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Gallagher, C., Bell, B., Bendlin, B., Palotti, M., Okonkwo, O., Sodhi, A., ... Johnson, S., ... Alexander, A. (2013). White matter microstructural integrity and executive function in Parkinson's disease. Journal of the International Neuropsychological Society, 19(3), 349-354.
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Willette, A. A., Xu, G., Johnson, S. C., Birdsill, A. C., Jonaitis, E. M., Sager, M. A., ... Asthana, S., & Bendlin, B. B (2013). Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes Care, 36(2), 443-449.
View publication via DOI: DOI:10.2337/dc12-0922

Ries, M.L., McLaren, D.G., Bendlin, B.B., Xu, G., Rowley, H.A., Birn, R., Kastman, E.K., Sager, M.A., Asthana, S., & Johnson, S.C. (2012). Medial prefrontal functional connectivity: relation to memory self-appraisal accuracy in older adults with and without memory disorders. Neuropsychologia, 50(5), 603-611.
View publication via DOI: DOI:10.1016/j.neuropsychologia.2011.12.014

Okonkwo, O.C., Xu, G., Dowling, N.M., Bendlin, B.B., La Rue, A., Hermann, . . . Asthana, S., Sager, M.A. & Johnson, S.C. (2012). Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults. Neurology, 78(22), 1769-1776.
View publication via DOI: DOI:10.1212/WNL.0b013e3182583047

Bendlin, B.B., Carlsson, C.M., Johnson, S.C., Zetterberg, H., Blennow, K., Willette, A.A., Okonkwo, O. C., ... Puglielli, L., Asthana, S., & Sager, M.A. (2012). CSF t-tau/A 42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease. Public Library of Science One, 7(6), e37720.
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Wharton, W.L., Stein, J.H., Korcarz, C., Sachs, J., Olson, S.R., Zetterberg, H., ... Johnson, S.C., Sager, M.A., Asthana, S., Carlsson, C.M. (2012). The effects of Ramipril in individuals at risk for Alzheimer's disease: Results of a pilot clinical trial. Journal of Alzheimer's Disease, 1387-2877.
View publication via DOI: DOI:10.3233/JAD-2012-120763

Willette, A.A., Bendlin, B.B., Colman, R.J., Kastman, E.K., Field, A.S., Alexander, A.L., ... Kemnitz, J.W., Weindruch, R.H., & Johnson, S. (2012). Calorie restriction reduces the influence of glucoregulator dysfunction on regional brain volume in aged rhesus monkeys. Diabetes, 61(5), 1036-1042.
View publication via DOI: DOI:10.2337/db11-1187

Skoog, I., Olesen, P.J., Blennow, K., Palmertz, B., Johnson, S.C., & Bigler, E.D. (2012). Head size may modify the impact of white matter lesions on dementia. Neurobiology of Aging, 33(7), 1186-1193.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2011.01.011

McLaren, D.G., Ries, M. L., Xu, G., & Johnson, S.C. (2012). A generalized form of context-dependent psychophysiological interactions (gPPI): A comparison to standard approaches. NeuroImage, 61(4), 1277-1286.
View publication via DOI: DOI:10.1016/j.neuroimage.2012.03.068

Willette, A.A., Gallagher, C., Bendlin, B.B., McLaren, D.G., Kastman, E.K., Canu, E., ... Weindruch, R.H., Coe, C.L., & Johnson, S.C. (2012). Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys. Neurobiology of Aging, 33(4), 670-680.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2010.06.003

Willette, A.A., Xu, G., Johnson, S.C., Birdsill, A.C., Jonaitis, E.M., Sager, M.A., ... Asthana, S., & Bendlin, B.B. (2012). Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes Care, 36(2), 443-449.
View publication via DOI: DOI:10.2337/dc12-0922

Sridharan, A., Willette, A. A., Bendlin, B. B., Alexander, A. L., Coe, C. L., Voytko, M. L., Coleman, R. J., Kemnitz, J. W., Weindruch, R. H., & Johnson, S. C. (2012). Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys. Front Aging Neurosci, 4, 31.
View publication via DOI: DOI:10.3389/fnagi.2012.00031

Willette, A. A., Coe, C. L., Colman, R. J., Bendlin, B. B., Kastman, E. K., Field, A. S., ... Weindruch, R. H., & Johnson, S. C. (2012). Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys. Psychoneuroendocrinology, 37(7), 903-916.
View publication via DOI: DOI:10.1016/j.psyneuen.2011.10.006

Okonkwo, O. C., Xu, G., Oh, J. M., Dowling, N. M., Carlsson, C. M., Gallagher, C., . . . Asthana, S., Sager, M. A., & Johnson, S. C. (2012). Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease. Cerebral Cortex. Advance online publication.
View publication via DOI: DOI:10.1093/cercor/bhs381

Farbota, K. D., Bendlin, B. B., Alexander, A. L., Rowley, H. A., Dempsey, R. J., & Johnson, S. C. (2012). Longitudinal diffusion tensor imaging and neuropsychological correlates in traumatic brain injury patients. Frontiers in Human Neuroscience, 6, 160.
View publication via DOI: DOI:10.3389/fnhum.2012.00160

Carlsson, C.M., Xu, G., Wen, Z., Barnet, J.H., Blazel, H.M., Chappell, Stein, J.H., Asthana, S., Sager, M.A., ... Johnson, S.C. (2011). Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: A pilot study. Current Alzheimer Research, 9(8), 990-997.
View publication via DOI: DOI:10.2174/156720512803251075

Johnson, S.C., La Rue, A., Hermann, B.P., Xu, G., Koscik, R.L., Jonaitis, E.M., ... Asthana, S., Green, R.C., & Sager, M.A. (2011). The effect of TOMM40 poly-t length on gray matter volume and cognition in middle-aged persons with APOE ɛ3/ɛ3 genotype. Alzheimer's and Dementia, 7(4), 456-465.
View publication via DOI: DOI:10.1016/j.jalz.2010.11.012

Pachauri, D., Hinrichs, C., Chung, M.K., Johnson, S.C., & Singh, V. (2011). Topology-based kernels with application to inference problems in Alzheimer's disease. Medical Imaging, IEEE Transactions on, 30(10), 1760-1770.
View publication via DOI: DOI:10.1109/tmi.2011.2147327

Austin, B.P., Nair, V.A., Meier, T.B., Xu, G., Rowley, H.A., Carlsson, C.M., Johnson, S.C., & Prabhakaran, V. (2011). Effects of hypoperfusion in Alzheimer's disease. Journal of Alzheimer's Disease, 26(3), 123-133.
View publication via DOI: DOI:10.3233/jad-2011-0010

Gallagher, C.L., Oakes, T.R., Johnson, S.C., Chung, M.K., Holden, J.E., Bendlin, B.B., ... Brown, W.D. (2011). Rate of 6-[18f]fluorodopa uptake decline in striatal subregions in Parkinson's disease. Movement Disorders, 26(4), 614-620.
View publication via DOI: DOI:10.1002/mds.23503

Hinrichs, C., Singh, V., Xu, G., & Johnson, S.C. (2011). Predictive markers for AD in a multi-modality framework: An analysis of MCI progression in the ADNI population. NeuroImage, 55(2), 574-589.
View publication via DOI: DOI:10.1016/j.neuroimage.2010.10.081

Gallagher, C. L., Johnson, S. C., Bendlin, B. B., Chung, M. K., Holden, J. E., Oakes, T. R., ... Brown, W. D. (2011). A longitudinal study of motor performance and striatal [18f]fluorodopa uptake in Parkinson's disease. Brain Imaging and Behavior, 5(3), 203-211.
View publication via DOI: DOI:10.1007/s11682-011-9124-5

Malandraki, G.A., Johnson, S.C., & Robbins, J. (2011). Functional MRI of swallowing: From neurophysiology to neuroplasticity. Head and Neck, 33(S1), S14-S20.
View publication via DOI: DOI:10.1002/hed.21903

Canu, E., McLaren, D.G., Fitzgerald, M.E., Bendlin, B.B., Zoccatelli, G., Alessandrini, F. ... Johnson, S. C., & Frisoni, G. B. (2011). Mapping the structural brain changes in Alzheimer's disease: The independent contribution of two imaging modalities. Journal of Alzheimer's Disease, 26(3), 263-274.
View publication via DOI: DOI:10.3233/jad-2011-0040

Bendlin, B. B., Canu, E., Willette, A., Kastman, E.K., McLaren, D.G., Kosmatka, K.J., ... Coe, C.L., Weindruch, R.H., Alexander, A.L., & Johnson, S. C. (2011). Effects of aging and calorie restriction on white matter in rhesus macaques. Neurobiology of Aging, 32(12), 2319.e1-2319.e11.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2010.04.008

Humbert, I.A., McLaren, D.G., Malandraki, G., Johnson, S.C., & Robbins, J. (2011). Swallowing Intentional Off-State in Aging and Alzheimer's disease: Preliminary Study. Journal of Alzheimer's Disease, 26(2), 347-54.
View publication via DOI: DOI:10.3233/JAD-2011-110380

Wharton, W., Baker, L. D., Gleason, C. E., Dowling, M., Barnet, J. H., Johnson, S., . . . Asthana, S. (2011). Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: Results of a randomized controlled trial. Journal of Alzheimer's Disease, 26(3), 495-505.
View publication via DOI: DOI:10.3233/jad-2011-110341

Bendlin, B.B., Fitzgerald, M.E., Ries, M.L., Xu, G., Kastman, E.K., Thiel, B.W., Rowley, H.A., Lazar, M., Alexander, A.L., & Johnson, S.C. (2010). White matter in aging and cognition: A cross-sectional study of microstructure in adults aged eighteen to eighty-three. Developmental Neuropsychology, 35(3), 257-277.
View publication via DOI: DOI:10.1080/87565641003696775

Bendlin, B.B., Carlsson, C.M., Gleason, C.E., Johnson, S.C., Sodhi, A., Gallagher, C.L., Puglielli, L., Engelman, C.D., Ries, M.L., Xu, G., Wharton, W., & Asthana, S. (2010). Midlife predictors of Alzheimer's disease. Maturitas, 65(2), 131-137.
View publication via DOI: DOI:10.1016/j.maturitas.2009.12.014

Humbert, I.A., McLaren, D.G., Kosmatka, K., Fitzgerald, M., Johnson, S., Porcaro, E., Kays, S., Umoh, E.O., & Robbins, J. (2010). Early deficits in cortical control of swallowing in Alzheimer's disease. Journal of Alzheimer's Disease, 19(4), 1185-97.
View publication via DOI: DOI:10.3233/JAD-2010-1316

Khachaturian, Z.S., Barnes, D., Einstein, R., Johnson, S., Lee, V., Roses, A., Sager, M.A., et. al. (2010). Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimer's & Dementia, 6(2), 89-97.
View publication via DOI: DOI:10.1016/j.jalz.2010.01.008

Bendlin, B.B., Newman, L.M., Ries, M.L., Puglielli, L., Carlsson, C.M., Sager, M.A., ... Asthana, S., & Johnson, S.C. (2010). NSAIDs may protect against age-related brain atrophy. Frontiers in Aging Neuroscience, 2(35).
View publication via DOI: DOI:10.3389/fnagi.2010.00035

Bendlin, B.B., Ries, M.L., Canu, E., Sodhi, A., Lazar, M., Alexander, A.L., Carlsson, C.M., Sager, M.A. Asthana, S., & Johnson, S. C. (2010). White matter is altered with parental family history of Alzheimer's disease. Alzheimer's & Dementia, 6(5), 394-403.
View publication via DOI: DOI:10.1016/j.jalz.2009.11.003

Ward, M. A., Bendlin, B. B., McLaren, D. G., Hess, T. M., Gallagher, C. L., Kastman, E. K., ... Asthana, S., .. Sager, M.A., & Johnson, S. C. (2010). Low HDL cholesterol is associated with lower gray matter volume in cognitively healthy adults. Frontiers in Aging Neuroscience, 2(29).
View publication via DOI: DOI:10.3389/fnagi.2010.00029

Willette, A.A., Bendlin, B.B., McLaren, D.G., Canu, E., Kastman, E.K., Kosmatka, K.J., ... Weindruch, R.H., Coe, C.L., & Johnson, S.C. (2010). Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys. NeuroImage, 51(3), 987-994.
View publication via DOI: DOI:10.1016/j.neuroimage.2010.03.015

Kastman, E.K., Willette, A.A., Coe, C.L., Bendlin, B.B., Kosmatka, K.J., McLaren, D.G., ... Weindruch, R.H., & Johnson, S. C. (2010). A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. The Journal of Neuroscience, 32(34), 11897-11904.
View publication via DOI: DOI:10.1523/JNEUROSCI.2553-12.2012

McLaren, D.G., Kosmatka, K.J., Kastman, E.K., Bendlin, B.B., & Johnson, S.C. (2010). Rhesus macaque brain morphometry: A methodological comparison of voxel-wise approaches. Methods, 50(3), 157-165.
View publication via DOI: DOI:10.1016/j.ymeth.2009.10.003

Xu, G., Rowley, H.A., Wu, G., Alsop, D.C., Shankaranarayanan, A., Dowling, M., ... Johnson, S.C. (2010). Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0t and comparison with 15o-water pet in elderly subjects at risk for Alzheimer's disease. NMR in Biomedicine, 23(3), 286-293.
View publication via DOI: DOI:10.1002/nbm.1462

Canu, E., McLaren, D. G., Fitzgerald, M. E., Bendlin, B. B., Zoccatelli, G., Alessandrini, F., ... Johnson, S. C., & Frisoni, G. B. (2010). Microstructural diffusion changes are independent of macrostructural volume loss in moderate to severe Alzheimer's disease. Journal of Alzheimer's Disease, 19(3), 963-976.
View publication via DOI: DOI:10.3233/jad-2010-1295

Lin, F., Wharton, W., Dowling, N.M., Ries, M.L., Johnson, S.C., Carlsson, C.M., Asthana, S., & Gleason, C. E. (2010). Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 30(1), 83-92.
View publication via DOI: DOI:10.1159/000318752

McLaren, D.G., Kosmatka, K.J., Oakes, T.R., Kroenke, C.D., Kohama, S.G., Matochik, J.A., Ingram D.K., & Johnson, S.C. (2009). A population-average MRI-based atlas collection of the rhesus macaque. Neuroimage, 45(1), 52-59.
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View publication via DOI: DOI:10.1016/j.neuroimage.2008.10.058

Xu, G., McLaren, D.G., Ries, M.L., Fitzgerald, M.E., Bendlin, B.B., Rowley, H.A., Sager, M.A., Atwood, C.S., Asthana, S., & Johnson, S.C. (2009). The influence of parental history of Alzheimer's disease and apolipoprotein E 4 on the BOLD signal during recognition memory. Brain, 132, 383-391.
View publication via DOI: DOI:10.1093/brain/awn254

Colman, R.J., Anderson, R.M., Johnson, S.C., Kastman, E.K., Kosmatka, K.J., T. Beasley, T.M., Allison, D.B., Cruzen, C., Simmons, H.A., Kemnitz, J.W., & Weindruch, R. (2009). Caloric restriction delays disease onset and mortality in rhesus monkeys. Science, 325, 201-204.
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View publication via DOI: DOI:10.1126/science.1173635

Hengen, K.B., Behan, M., Carey, H.V., Jones, M.V., & Johnson, S.M. (2009). Hibernation induces pentobarbital insensitivity in medulla but not cortex. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 297(4), 1028-1036.
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View publication via DOI: DOI:10.1152/ajpregu.00239.2009

Gleason, C.E., Carlsson, C.M., Barnet, J.H., Meade, S.A., Setchell, K.D., Atwood, C.S., Johnson, S.C., Ries, M.L., & Asthana, S. (2009). A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women. Age and Ageing, 38(1), 86-93.
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View publication via DOI: DOI:10.1093/ageing/afn227

Humbert, I.A., Fitzgerald, S., McLaren, D., Johnson, S., Porcaro, E., Kosmatka, K., Hind, J., & Robbins, J. (2009). Neurophysiology of swallowing: Effects of age and bolus type. NeuroImage, 44(3), 982-991.
View publication via DOI: DOI:10.1016/j.neuroimage.2008.10.012

Asenath, L.R., Hermann, B., Jones, J., Johnson, S.C., Asthana, S., & Sager, M.A. (2008). Effect of family history of Alzheimer's disease on serial position profiles. Alzheimer's and Dementia, 4(4), 285-290.
View publication via DOI: DOI:10.1016/j.jalz.2008.03.009

Haasl, R.J., Reza Ahmadi, M., Vadakkadath Meethal, S., Gleason, C.E., Johnson, S.C., Asthana, S., Bowen, R.L., & Atwood, C.S. (2008). A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E e4 Allele. BMC Medical Genetics, 9(1), 37.
View publication via DOI: DOI:10.1186/1471-2350-9-37

Ries, M.L., Carlsson, C.M., Rowley, H.R., Sager, M.A., Gleason, C.E., Asthana, S., & Johnson, S.C. (2008). MRI characterization of brain structure and function in Mild Cognitive Impairment: A review. Journal of the American Geriatrics Society, 56(5), 920-934.
View publication via DOI: DOI:10.1111/j.1532-5415.2008.01684.x

Xu, G., Fitzgerald, M.E., Wen, Z., Fein, S., Alsop, D., Carroll, T., Ries, M., Rowley, H., Sager, M., Asthana, S., Johnson, S.C., & Carlsson, C.M. (2008). Atorvastatin therapy is associated with greater and faster cerebral hemodynamic response. Brain Imaging and Behavior, 2(2), 94-104.
View publication via DOI: DOI:10.1007/s11682-007-9019-7

Carlsson, C.M., Gleason, C.E., Hess, T.M., Moreland, K.A., Blazel, H.M., Koscik, R.L., Schreiber, N.T.N., Johnson, S.C., Atwood, C.S., Puglielli, L., Hermann, B.P., McBride, P.E., Stein, J.H., Sager, M.A., & Asthana, S. (2008). Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimers disease. Journal of Alzheimers Disease, 13(2), 187-97.

Trivedi, M.A., Schmitz, T.W., Ries, M.L., Hess, T.M., Fitzgerald, M.E., Atwood, C.S., Rowley, H.A., Asthana, S., Sager, M.A., & Johnson, S.C. (2008). fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: Risk factors for Alzheimer's disease. Neuropsychologia, 46(6), 1667-1678.
View publication via DOI: DOI:10.1016/j.neuropsychologia.2007.11.035

Bendlin, B.B., Ries, M.L., Lazar, M., Alexander, A.L., Dempsey, R.J., Rowley, H.A., Sherman, J.E., & Johnson, S.C. (2008). Longitudinal changes in patients with traumatic brain injury assessed with diffusion tensor and volumetric imaging. Neuroimage, 42, 503-51.
View publication via DOI: DOI:10.1016/j.neuroimage.2008.04.254

Johnson, S.C., Schmitz, T.W., Asthana, S., Gluck, M.A., & Myers, C.E. (2008). Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment. Aging, Neuropsychology, and Cognition, 15, 129-14.
View publication via DOI: DOI:10.1080/13825580601139444

Johnson, S.C., Ries, M.L., Hess, T.M., Carlsson, C.M., Gleason, C.E., Alexander, A.L., Rowley, H.A., Asthana, S., & Sager, M.A. (2007). Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults. Archives of General Psychiatry, 64(10), 1163-1171.
View publication via DOI: DOI:10.1001/archpsyc.64.10.1163

Ries, M.L., Jabbar, B.M., Schmitz, T.W., Trivedi, M.A., Gleason, C.M., Rowley, H.A., Asthana, S., & Johnson, S.C. (2007). Anosognosia in MCI: Relationship to activation of cortical midline structures involved in self-appraisal. Journal of the International Neuropsychological Society, 13, 450-61.
View publication via DOI: DOI:10.1017/S1355617707070488

Wung, J.K., Perry, G., Kowalski, A.., Harris, P.L.R., Bishop, G.M., Trivedi, M.A., Johnson, S.C., Smith, M.A., Denhardt, D.T., & Atwood, C.S. (2007). Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the alzheimer's disease brain. Current Alzheimer Research, 4(1), 67-72.
View publication via DOI: DOI:10.2174/156720507779939869

Trivedi, M.A., Ward, M.A., Hess, T.M., Gale, S.D., Dempsey, R.J., Rowley, H.A., & Johnson, S.C. (2007). Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of coma. Journal of Neurotrauma, 24, 766-77.
View publication via DOI: DOI:10.1089/neu.2006.0205

Schmitz, T.W., & Johnson, S.C. (2007). Relevance to the self: A brief review and framework of neural systems underlying appraisal. Neuroscience and Biobehavioral Reviews, 31, 585-59.
View publication via DOI: DOI:10.1016/j.neubiorev.2006.12.003

Schmitz, T.W., & Johnson, S.C. (2006). Self-appraisal decisions evoke dissociated dorsal-ventral aMPFC networks. Neuroimage, 30(3), 1050-1058.
View publication via DOI: DOI:10.1016/j.neuroimage.2005.10.030

Trivedi, M.A., Schmitz, T.W., Ries, M.L., Torgerson, B.M., Sager, M.A., Hermann, B.P., Asthana, S., & Johnson, S.C. (2006). Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk for Alzheimer's Disease: a cross-sectional study. BMC Medicine, 4, 1.
View publication via DOI: DOI:10.1186/1741-7015-4-1

Gleason, C.E., Schmitz, T.W., Hess, T., Koscik, R.L., Trivedi, M.A., Ries, M.L., Carlsson, C.M., Sager, M.A., Asthana, S., & Johnson, S.C. (2006). Hormone effects on fMRI and cognitive measures of encoding: Importance of hormone preparation. Neurology, 67, 2039-204.
View publication via DOI: DOI:10.1212/01.wnl.0000247277.81400.43

Johnson, S.C., Schmitz, T.W., Trivedi, M.A., Ries, M.L., Torgerson, B.M., Carlsson, C.M., Asthana, S., Hermann, B.P., & Sager, M.A. (2006). The influence of AD family history and APOE4 on mesial temporal lobe activation. Journal of Neuroscience, 26, 6069-607.
View publication via DOI: DOI:10.1523/JNEUROSCI.0959-06.2006

Johnson, S.C., Schmitz, T.W., Moritz, C.H., Meyerand, M.E., Rowley, H.A., Alexander, A.L., Hansen, K.W., Gleason, C.E., Carlsson, C.M., Ries, M.L., Asthana, S., Chen, K., Reiman, E.M., & Alexander, G.E. (2006). Activation of brain regions vulnerable to Alzheimer's disease: The effect of mild cognitive impairment. Neurobiology of Aging, 27, 1604-161.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2005.09.017

Johnson, S.C., Schmitz, T.W., Rowley, H.A., Alexander, A.L., Lee, J., & Davidson, R.J. (2005). The cerebral response during subjective choice with and without self-reference. J. Cogn. Neurosci., 17(12), 1897-1906.
View publication via DOI: DOI:10.1162/089892905775008607

Ward, M.A., Carlsson, C.M., Trivedi, M.A., Sager, M.A., & Johnson, S.C. (2005). The effect of body mass index on global brain volume in middle-aged adults: A cross-sectional study. BMC Neurol., 5(23).
View publication via DOI: DOI:10.1186/1471-2377-5-23

Gleason, C.E., Cholerton, B., Carlsson, C.M., Johnson, S.C., & Asthana, S. (2005). Neuroprotective effects of female sex steroids in humans: Current controversies and future directions. Cell. Mol. Life Sci., 62(3), 299-312.
View publication via DOI: DOI:10.1007/s00018-004-4385-z

Gleason, C.E., Carlsson, C.M., Johnson, S.C., Atwood, C., & Asthana, S. (2005). Clinical pharmacology and differential cognitive efficacy of estrogen preparations. Annals of the New York Academy of Science, 1052, 93-115.
View publication via DOI: DOI:10.1196/annals.1347.007

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