Untitled Document

Research

Lisa Colbert

MPH, Ph.D. University of South Carolina
Assistant Professor, Departments of Kinesiology and Population Health Sciences
lhcolbert@education.wisc.edu
http://www.education.wisc.edu/kinesiology/faculty/#Colbert

Physical Activity in Cancer Prevention & Control

Research in my lab primarily focuses on the role of physical activity in cancer prevention & control. Higher levels of physical activity are associated with reduced risk of colon and breast cancers in epidemiological studies, and there is accumulating evidence that greater activity is also associated with cancers of other types such as endometrial and lung cancers. Some of the current questions we are addressing are: What are the mechanisms which explain these associations? What are the doses of physical activity or exercise necessary to achieve benefits? What is the role of physical activity in the survivorship of persons diagnosed with cancer?

Currently, we are examining the relationships between physical activity, pain, and physical function in older colorectal cancer survivors. We have surveyed ~950 people in the state of WI who were diagnosed at age 65 or older, and who have lived 5-10 yrs beyond their diagnosis, to explore these relationships. We are also beginning a project aimed at examining the validity of various methods for measuring physical activity in older adults. Determining the best tool to accurately assess activity will allow us to explore dose-response relationships between activity and various outcomes, including physical function in cancer survivors.

Although most of our work uses epidemiologic methods, we also use animal models of cancer to explore the role of exercise in tumorigenesis. These models allow us to look at potential mechanisms that would be difficult to examine in humans.

Representative Publications
Colbert, L.H., Graubard, B.I., Michels, K.B., Willett, W.C., Forman, M.R. (2008). Physical activity during pregnancy and age at menarche of the daughter. Cancer Epidemiol. Biomarkers Prev., 17(10), 2656-62.

Rogers, C.J., Colbert, L.H., Greiner, J.W., Perkins, S.N., Hursting, S.D. (2008). Physical activity and cancer prevention: pathways and targets for intervention. Sports Med., 38(4), 271-96.

Hursting, S.D., Lashinger, L.M., Wheatley, K.W., Rogers, C.J., Colbert, L.H., Nunez, N.P., Perkins, S.N. (2008). Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis link. Best Pract. Res. Clin. Endocrinol. Metab., 22(4), 659-69.

Hursting, S.D., Lashinger, L.M., Colbert, L.H., Rogers, C.J., Wheatley, K.W., Nunez, N.P., Mahabir, S., Barrett, J.C., Forman, M.R., Perkins, S.N. (2007). Energy balance and carcinogenesis: underlying pathways and targets for intervention. Curr. Cancer Drug Targets, 7(5), 484-91.

Catov, J.M., Newman, A.B., Roberts, J.M., Sutton-Tyrrell, K.C., Kelsey, S.F., Harris, T., Jackson, R., Colbert, L.H., Satterfield, S., Ayonayon, H.N., & Ness, R.B. (2007). Association between infant birth weight and maternal cardiovascular risk factors in the health, aging, and body composition study. Ann. Epidemiol., 17(1), 36-43.

Mai, V., Colbert, L.H., Perkins, S.N., Schatzkin, A., Hursting, S.D. (2007). Intestinal microbiota: a potential diet-responsive prevention target in ApcMin mice. Mol. Carcinog., 46(1), 42-8.

de Rekeneire, N., Peila, R., Ding, J., Colbert, L.H., Visser, M., Shorr, R.I., Kritchevsky, S.B., Kuller, L.H., Strotmeyer, E.S., Schwartz, A.V., Vellas, B., Harris, T.B. (2006). Diabetes, hyperglycemia, and inflammation in older individuals: the health, aging and body composition study. Diabetes Care, 29(8), 1902-8.

Calton, B.A., Lacey, J.V., Schatzkin, A., Schairer, C., Colbert, L.H., Albanes, D., Leitzmann, M.F. (2006). Physical activity and the risk of colon cancer among women: a prospective cohort study (United States). Int. J. Cancer, 119(2), 385-91.

Pettee, K.K., Brach, J.S., Kriska, A.M., Boudreau, R., Richardson, C.R., Colbert, L.H., Satterfield, S., Visser, M., Harris, T.B., Ayonayon, H.N., Newman, A.B. (2006). Influence of marital status on physical activity levels among older adults. Med. Sci. Sports. Exerc., 38(3), 541-6.

Colbert, L.H., Mai, V., Tooze, J., Perkins, S.N., Berrigan, D., Hursting, S.D. (2006). Negative energy balance induced by voluntary wheel running inhibits polyp development in APCmin mice. Carcinogenesis, 27, 2103-7.

Manini, T.M., Everhart, J.E., Patel, K.V., Schoeller, D.A., Colbert, L.H., Visser, M., Tylavsky, F., Bauer, D.C., Goodpaster, B.H., & Harris, T.B. (2006). Daily activity energy expenditure and mortality among older adults. JAMA, 296, 171-9.

Visser, M., Simonsick, E.M., Colbert, L.H., Brach, J., Rubin, S.M., Kritchevsky, S.B., Newman, A.B., Harris, T.B., for the Health ABC Study. (2005). Type and intensity of activity and risk of mobility limitation: the mediating role of muscle parameters. J. Am. Geriatr. Soc., 53, 762-770.

Il�yasova, D., Colbert, L.H., Harris, T.B., Newman, A.B., Bauer, D.C., Satterfield, S., Kritchevsky, S.B. (2005). Circulating levels of inflammatory markers and cancer risk in the Health Aging and Body Composition cohort. Cancer Epid. Biomark. Prev., 14, 2413-8.

Colbert, L.H., Visser, M., Simonsick, E., Tracy, R., Newman, A., Kritchevsky, S., Pahor, M., Taafe, D., Brach, J., Cummings, S., Rubin, S., & Harris, T.B. (2004). Physical activity, exercise, and inflammatory markers in older adults: Findings from Health ABC. J. Am. Geriatr. Soc., 52(7), 1098-1104.

Colbert, L.H., Mai, V., Perkins, S.N., Berrigan, D., Lavigne, J.A., Wimbrow, H.H., Alvord, W.G., Haines, D.C., Srinivas, P., & Hursting, S.D. (2003). Exercise and intestinal polyp development in Apc^Min mice. Med. Sci. Sports Exerc., 35, 1662-1669.

Holvoet, P., Harris, T.B., Tracy, R.P., Verhamme, P., Newman, A.B., Rubin, S.M., Simonsick, E.M., Colbert, L.H., & Kritchevsky, S.B. (2003). Association of high coronary heart disease risk status with circulating oxidized LDL in well-functioning elderly: findings from the Health, Aging and Body Composition Study. Arterioscler. Thromb. Vasc. Biol., 23, 1444-1448.

Colbert, L.H., Lacey, Jr., J., Albert, P., Schairer, C., Schatzkin, A., & Albanes, D. (2003). Physical activity and the risk of endometrial cancer in a prospective study. Cancer Causes Control, 14, 559-567.

Colbert, L.H., Hartman, T.J., Tangrea, J.A., Pietinen, P., Virtamo, J., Taylor, P.R., & Albanes D. (2002). Physical activity and lung cancer risk in male smokers. Int. J. Cancer, 98(5), 770-773.

Colbert, L.H., Lanza, E., Ballard-Barbash, R., Slattery, M.L., Tangrea, J.A., Caan, B., Paskett, E.D., Iber, F., Kikendall, W., Lance, P., Shike, M., Schoen, R.E., Daston, C., & Schatzkin, A., the Polyp Prevention Trial Study Group. (2002). Adenomatous polyp recurrence and physical activity in the Polyp Prevention Trial (United States). Cancer Causes Control, 13, 445-453.

Colbert, L.H., Hartman, T.J., Malila, N., Limburg, P.J., Pietinen, P., Virtamo, J., Taylor, P.R., & Albanes, D. (2001). Physical activity in relation to cancer of the colon and rectum in a cohort of male smokers. Cancer Epidemiol. Biomarkers Prev., 10, 265-268.

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