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Annual
COLLOQUIUM
ON AGING
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Event Speakers

IOA Newsletter,
AGING NEWS:

Cover of Aging News

MIDUS
Newsletters
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MIDUS Inequality newsletter cover

Training Grant-
Biology of Aging
:

Christopher Coe

Christopher L. Coe

Ph.D., Downstate Medical Center, SUNY
Professor, Department of Psychology
ccoe@wisc.edu
http://psych.wisc.edu/faculty-coe.htm


Psychoneuroimmunology: The Relationship between Behavior, Emotions and the Immune System

My research program focuses on how psychological, environmental and dietary factors influence health and immunity. We emphasize two points in the life span when there is a heightened vulnerability to disease: infancy and old age. This early and late orientation reflects my belief that the potential effect of psychological factors on physiological processes and the risk for illness is more significant at these times. During infancy, parenting and other early rearing events can exert long-lasting effects on the developing brain and immune system by altering the maturational trajectory. Similarly, in the elderly individual, psychological processes can induce irreversible changes in immune competence and host defense by moderating the process of immune senescence, which underlies the progressive decline in immunity in old age.

We conduct studies with human participants, including healthy individuals and patient populations, and also use animal models. As an example of the latter research, we characterized when old monkeys experience immune declines, determined responses to vaccination, and individual variation in the age-related changes that typically occur after they 20 years of age. It is also important to have a better understanding how neural and immune system communicate and the mediating pathways. We have a fully equipped biochemical laboratory for conducting immune assays. That capacity also enables us to serve as the biomarker core facility for the MIDUS and MIDJA surveys of health and aging in the US and Japan. These studies enable us to consider cultural and life style influences on many different hormone and immune processes associated with the promotion of health or underlying disease pathology.



Representative Publications
Rendina, D. N., Ryff, C. D., & Coe, C. L. (2017). Precipitous dehydroepiandrosterone declines reflect decreased physical vitality and function. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(6), 747-753.
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View publication via DOI: DOI:10.1093/gerona/glw135

Lee, C., Coe, C. L., & Ryff, C. D. (2017). Social disadvantage, severe child abuse, and biological profiles in adulthood. Journal of Health and Social Behavior. Advance online publication.
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View publication via DOI: DOI:10.1177/0022146516685370

Miller, R., Stalder, T., Jarczok, M., Almeida, D. M., Badrick, E., Bartels, M., Boomsma, D. I., Coe, C. L., Dekker, M. C. J., Donzella, B., Fischer, J. E., Gunnar, M. R., Kumari, M., Lederbogen, F., Power, C., Ryff, C. D., Subramanian, S. V., Tiemeier, H. (2016). The CIRCORT database: Reference ranges and seasonal changes in diurnal salivary cortisol derived from a meta-dataset comprised of 15 field studies. Psychoneuroendocrinology, 73, 16-23.
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View publication via DOI: DOI:10.1016/j.psyneuen.2016.07.201

Levine, C. S., Miyamoto, Y., Markus, H. R., Rigotti, A., Boylan, J. M., Park, J., Kitayama, S., Karasawa, M., Kawakami, N., Coe, C. L., Love, G. D., & Ryff, C. D. (2016). Culture and healthy eating: The role of independence and interdependence in the United States and Japan. Personality and Social Psychology Bulletin, 42(10), 1335-1348.
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View publication via DOI: DOI:10.1177/0146167216658645

Honerlaw, K. R., Rumble, M. E., Rose, S. L., Coe, C. L., & Costanzo, E. S. (2016). Biopsychosocial predictors of pain among women recovering from surgery for endometrial cancer. Gynecologic Oncology, 140(2), 301-306.
View publication via DOI: DOI:10.1016/j.ygyno.2015.09.005

Ryff, C. D., Boylan, J. M., Coe, C. L., Karasawa, M., Kawakami, N., Kitayama, S., Kan, C., Love, G. D., Levine, C. L., Markus, H. R., Miyamoto, Y., Nakahara, J., & Park, J. (2015). Adult development in Japan and the U.S.: Comparing theories and findings about growth, maturity, and well-being. In L. Jensen (Ed.), Oxford handbook of human development and culture: An interdisciplinary perspective. New York: Oxford University Press.
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View publication via DOI: DOI:10.1093/oxfordhb/9780199948550.013.41

Kitayama, S., Park, J., Boylan, J., Miyamoto, Y., Levine, C., Markus, H. R., Karasawa, M., Coe, C., Kawakami, N., Love, G., & Ryff, C. (2015). Expression of anger and ill health in two cultures: An examination of inflammation and cardiovascular risk. Psychological Science, 26(2), 211-220.
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View publication via DOI: DOI:10.1177/0956797614561268

Ryff, C. D., Miyamoto, Y., Boylan, J. M., Coe, C. L., Karasawa, M., Kawakami, N., Kan, C., Love, G. D., Levine, C., Markus, H. R., Park, J., & Kitayama, S. (2015). Culture, inequality, and health: Evidence from the MIDUS and MIDJA comparison. Culture and Brain, 3(1), 1-20.
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View publication via DOI: DOI:10.1007/s40167-015-0025-0

Fuller-Rowell, T.E., Curtis, D.S., Doan, S.N., & Coe, C.L. (2015). Racial disparities in the health benefits of educational attainment: A study of inflammatory trajectories among African American and White adults. Psychosomatic Medicine, 77(1), 33-40.
View publication via DOI: DOI:10.1097/PSY.0000000000000128

Boylan, J., Lewis, T., Coe, C., & Ryff, C. (2015). Educational status, anger, and inflammation in the MIDUS national sample: Does race matter? Annals of Behavioral Medicine, 49(4), 570-578.
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View publication via DOI: DOI:10.1007/s12160-015-9687-2

Amaral, W. Z., Krueger, R. F., Ryff, C. D., & Coe, C. L. (2015). Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: Insights from identical and fraternal twins. Brain, Behavior, and Immunity, 49, 171-181.
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View publication via DOI: DOI:10.1016/j.bbi.2015.05.010

Costello-White, R., Ryff, C. D., & Coe, C. L. (2015). Aging and low-grade inflammation reduce renal function in middle-aged and older adults in Japan and the USA. Age, 37(4), Article 75.
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View publication via DOI: DOI:10.1007/s11357-015-9808-7

Leeson, L.A., Nelson, A.M., Rathouz, P.J., Juckett, M.B., Coe, C.L., Caes, E.W., & Costanzo, E.S. (2015). Spirituality and the recovery of quality of life following hematopoietic stem cell transplantation. Health Psychology, 34(9), 920-928.
View publication via DOI: DOI:10.1037/hea0000196

Song, J., Mailick, M. R., Ryff, C. D., Coe, C. L., Greenberg, J. S., & Hong, J. (2014). Allostatic load in parents of children with developmental disorders: Moderating influence of positive affect. Journal of Health Psychology, 19(2), 262-272.
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View publication via DOI: DOI:10.1177/1359105312468193

Tsenkova, V. K., Carr, D., Coe, C. L., & Ryff, C. D. (2014). Anger, adiposity, and glucose control in nonidabetic adults: Findings from MIDUS II. Journal of Behavioral Medicine, 37(1), 37-46.
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View publication via DOI: DOI:10.1007/s10865-012-9460-y

Kan, C., Kawakami, N., Karasawa, M., Love, G. D., Coe, C. L., Miyamoto, Y., Ryff, C. D., Kitayama, S., Curhan, K. B., & Markus, H. R. (2014). Psychological resources as mediators of the association between social class and health: Comparative findings from Japan and the U.S. International Journal of Behavioral Medicine, 21(1), 53-65.
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View publication via DOI: DOI:10.1007/s12529-012-9249-y

Curhan, K. B., Levine, C. S., Markus, H. R., Kitayama, S., Park, J., Karasawa, M., Kawakami, N., Love, G. D., Coe, C. L., Miyamoto, Y., & Ryff, C. D. (2014). Subjective and objective hierarchies and their relations to psychological well-being: A U.S./Japan comparison. Social Psychological and Personality Science, 5(8), 855-864.
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View publication via DOI: DOI:10.1177/1948550614538461

Wong, J. D., Mailick, M. R., Greenberg, J. S., Hong, J., & Coe, C. L. (2014). Daily work stress and awakening cortisol in mothers of individuals with autism spectrum disorders or Fragile X syndrome. Family Relations, 63(1), 135-147.
View publication via DOI: DOI:10.1111/fare.12055

Curhan, K. B., Sims, T., Markus, H. R., Kitayama, S., Karasawa, M., Kawakami, N., Love, G. D., Coe, C. L., Miyamoto, Y., & Ryff, C. D. (2014). Just how bad negative affect is for your health depends on culture. Psychological Science, 25(12), 2277-2280.
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View publication via DOI: DOI:10.1177/0956797614543802

Park, J., Kitayama, S., Karasawa, M., Curhan, K., Markus, H. R., Kawakami, N., Miyamoto, Y., Love, G. D., Coe, C. L., Ryff, C. D. (2013). Clarifying the links between social support and health: Culture, stress, and neuroticism matter. Journal of Health Psychology, 18(2), 226-235.
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View publication via DOI: DOI:10.1177/1359105312439731

Swann, J. R., Spagou, K., Lewis, M., Nicholson, J. K., Glei, D. A., Seeman, T. E., Coe, C. L., Goldman, N., Ryff, C. D.. . . Holmes, E. (2013). Microbial-mammalian co-metabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American Populations Journal of Proteome Research, 12(7), 3166-3180.
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View publication via DOI: DOI:10.1021/pr4000152

Miyamoto, Y., Boylan, J. M., Coe, C. L., Curhan, K. B., Levine, C. S., Markus, H. R., ...Ryff, C. D. (2013). Negative emotions predict elevated interleukin-6 in the United States but not in Japan. Brain, Behavior, and Immunity, 34, 79-85.
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View publication via DOI: DOI:10.1016/j.bbi.2013.07.173

Park, J., Kitayama, S., Markus, H. R., Coe, C. L., Miyamoto, Y., Karasawa, M., ...Ryff, C. D. (2013). Social status and anger expression: The cultural moderation hypothesis. Emotion, 13(6), 1122-1131.
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View publication via DOI: DOI:10.1037/a0034273

Obasi, C. N., Brown, R., Ewers, T., Barlow, S., Gassman, M., Zgierska, A., Coe, C. L., & Barrett, B. (2013). Advantage of meditation over exercise in reducing cold and flu illness is related to improved function and quality of life. Influenza and Other Respiratory Viruses, 7(6), 938-944.
View publication via DOI: DOI:10.1111/irv.12053

Hayney, M. S., Coe, C. L., Muller, D., Obasi, C. N., Backonja, U., Ewers, T., & Barrett, B. (2013). Age and psychological influences on immune responses to trivalent inactivated influenza vaccine in the meditation or exercise for preventing acute respiratory infection (MEPARI) trial. Human Vaccines and Immunotherapeutics, 10(1). Advance online publication.
View publication via DOI: DOI:10.4161/hv.26661

Willette, A. A., Coe, C. L., Birdsill, A. C., Bendlin, B. B., Colman, R. J., Alexander, A. L., ... Weindruch, R. H., & Johnson, S. C. (2013). Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age, 35(6), 2215-2227.
View publication via DOI: DOI:10.1007/s11357-013-9518-y

Costanzo, E. S., Stawski, R. S., Ryff, C. D., Coe, C. L., & Almeida, D. M. (2012). Cancer survivors' responses to daily stressors: Implications for quality of life. Health Psychology, 31(3), 360-370.
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View publication via DOI: DOI:10.1037/a0027018

Barrett, B., Hayney, M.S., Muller, D., Rakel, D., Ward, A., Obasi, O.N., ... Coe, C.L. (2012). Meditation or Exercise for Preventing Acute Respiratory Infection: A Randomized Controlled Trial. Annals of Family Medicine, 10(4), 337-346.
View publication via DOI: DOI:10.1370/afm.1376

Willette, A.A., Gallagher, C., Bendlin, B.B., McLaren, D.G., Kastman, E.K., Canu, E., ... Weindruch, R.H., Coe, C.L., & Johnson, S.C. (2012). Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys. Neurobiology of Aging, 33(4), 670-680.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2010.06.003

Wong, J. D., Mailick, M.R., Greenberg, J. S., Hong, J., Almeida, D. M., & Coe, C. L. (2012). Stressful life events and daily stressors affect awakening cortisol level in midlife mothers of individuals with autism spectrum disorders. Aging and Mental Health, 16(8), 939-949.
View publication via DOI: DOI:10.1080/13607863.2012.688191

Mailick, M.R, Barker, E.T., Greenberg, J.S., Hong, J., Coe, C., & Almeida, D. (2012). Differential sensitivity to life stress in FMR1 premutation carrier mothers of children with fragile X syndrome. Health Psychology, 31(5), 612-622.
View publication via DOI: DOI:10.1037/a0026528

Hartley, S., Mailick, M.R, Hong, J., Greenberg, J., Smith, L., Almeida, D., Coe, C., & Abbeduto, L. (2012). Cortisol response to behavior problems in FMR1 premutation mothers of adolescents and adults with fragile X syndrome: A diathesis-stress model. International Journal of Behavior and Development 36(1), 53-61.
View publication via DOI: DOI:10.1177/0165025411406857

Sridharan, A., Willette, A. A., Bendlin, B. B., Alexander, A. L., Coe, C. L., Voytko, M. L., Coleman, R. J., Kemnitz, J. W., Weindruch, R. H., & Johnson, S. C. (2012). Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys. Front Aging Neurosci, 4, 31.
View publication via DOI: DOI:10.3389/fnagi.2012.00031

Willette, A. A., Coe, C. L., Colman, R. J., Bendlin, B. B., Kastman, E. K., Field, A. S., ... Weindruch, R. H., & Johnson, S. C. (2012). Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys. Psychoneuroendocrinology, 37(7), 903-916.
View publication via DOI: DOI:10.1016/j.psyneuen.2011.10.006

Tsenkova, V. K., Carr, D., Coe, C. L., & Ryff, C. D. (2012). Synergistic effect of neuroticism and body mass index on glucose metabolism in nondiabetic adults. Psychotherapy and Psychosomatics, 81(5), 327-328.
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View publication via DOI: DOI:10.1159/000337413

Coe, C. L., Love, G. D., Karasawa, M., Kawakami, N., Kitayama, S., Markus, H. R., . . . Ryff, C. D. (2011). Population differences in proinflammatory biology: Japanese have healthier profiles than Americans. Brain, Behavior, and Immunity, 25(3), 494-502.
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View publication via DOI: DOI:10.1016/j.bbi.2010.11.013

Bendlin, B. B., Canu, E., Willette, A., Kastman, E.K., McLaren, D.G., Kosmatka, K.J., ... Coe, C.L., Weindruch, R.H., Alexander, A.L., & Johnson, S. C. (2011). Effects of aging and calorie restriction on white matter in rhesus macaques. Neurobiology of Aging, 32(12), 2319.e1-2319.e11.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2010.04.008

Seltzer, M. M., Greenberg, J. S., Hong, J., Smith, L. E., Almeida, D. M., Coe, C., et al. (2010). Maternal cortisol levels and behavior problems in adolescents and adults with ASD. Journal of Autism and Developmental Disorders, 40(4), 457-469.
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View publication via DOI: DOI:10.1007/s10803-009-0887-0

Morozink, J. A., Friedman, E. M., Coe, C. L., & Ryff, C. D. (2010). Socioeconomic and psychosocial predictors of interleukin-6 in the MIDUS national sample. Health Psychology, 29(6), 626-635.
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View publication via DOI: DOI:10.1037/a0021360

Willette, A.A., Bendlin, B.B., McLaren, D.G., Canu, E., Kastman, E.K., Kosmatka, K.J., ... Weindruch, R.H., Coe, C.L., & Johnson, S.C. (2010). Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys. NeuroImage, 51(3), 987-994.
View publication via DOI: DOI:10.1016/j.neuroimage.2010.03.015

Kastman, E.K., Willette, A.A., Coe, C.L., Bendlin, B.B., Kosmatka, K.J., McLaren, D.G., ... Weindruch, R.H., & Johnson, S. C. (2010). A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. The Journal of Neuroscience, 32(34), 11897-11904.
View publication via DOI: DOI:10.1523/JNEUROSCI.2553-12.2012

Lemieux, A., Coe, C., & Carnes, M. (2008). Symptom severity predicts degree of T cell activation in adult women following childhood maltreatment. Brain, Behavior, and Immunity, 22(6), 994-1003.
View publication via DOI: DOI:10.1016/j.bbi.2008.02.005

Backonja, M.M., Coe, C.L., Muller, D.A., & Schell, K. (2008). Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients. J. of Neuroimmunology, 195(1-2), 157-163.
View publication via DOI: DOI:10.1016/j.jneuroim.2008.01.005

Strauman, T., Coe, C., McCrudden, M., Vieth, A., & Kwapil, L. (2008). Individual differences in self-regulatory failure and menstrual dysfunction predict upper respiratory infection symptoms and antibody response to flu immunization. Brain, Behavior, and Immunity, 22(5), 769-780.
View publication via DOI: DOI:10.1016/j.bbi.2008.01.004

Coe, C., & Laudenslager, M. (2007). Psychosocial influences on immunity, including effects on immune maturation and senescence. Brain, Behavior, and Immunity, 21(8), 1000-1008.
View publication via DOI: DOI:10.1016/j.bbi.2007.06.015

Loevinger, B.L., Muller, D., Alonso, C., & Coe, C.L. (2007). Metabolic syndrome in women with chronic pain. Metabolism, 56, 87-93.
View publication via DOI: DOI:10.1016/j.metabol.2006.09.001

Hodgson, D.M., & Coe, C.L. (2006). Perinatal programming: Early life determinants of adult health and disease. London: Taylor and Francis.

Coe, C. L., & Lubach, G. R. (2006). Prenatal influences on the development of immunity. J. of Neuroimmunology, 178(Suppl. 1), 35.

Zondervan, K.T., Weeks, D.E., Colman, R.C., Cardon, L.R., Hadfield, R., Scheffler, J., Goudy, T.A, Coe, C.L., Kemnitz, J.W., & Kennedy, S.H. (2004). Familial aggregation of endometriosis in a large pedigree of rhesus macaques. Human Reproduction, 19, 448-455.
View publication via DOI: DOI:10.1093/humrep/deh052

Bailey, M.T., & Coe, C.L. (2002). Endometriosis is associated with altered intestinal microflora in the female rhesus monkey. Human Reproduction 17(7), 1704-1708.
View publication via DOI: DOI:10.1093/humrep/17.7.1704

Coe, C.L., & Ershler, W.B. (2001). Intrinsic and environmental influences on immune senescence in the aged monkey. Physiology and Behavior 73, 379-384.
View publication via DOI: DOI:10.1016/S0031-9384(01)00491-7

Coe, C.L. (1999). Psychosocial factors and psychoneuroimmunology within a life span perspective. In D.Keating (Ed.), Developmental health and the wealth of nations. New York: Guilford Press.

Davidson, R.J., Coe, C.L., Dolski, I., & Donzella, B. (1999). Individual differences in prefrontal activation a symmetry predict natural killer cell activity at rest and in response to challenge. Brain, Behavior, and Immunity, 13, 93-108.
View publication via DOI: DOI:10.1006/brbi.1999.0557

Coe, C.L., Lemieux, A.M., Rier, S.E., Uno, H., & Zimbric, M.L. (1998). Profile of endometriosis in the aging female rhesus monkey. Journal of Gerontology Medical Sciences, 53A(1), 3-7.
View publication via DOI: DOI:10.1093/gerona/53A.1.M3

Rogers, S.L., Coe, C.L., & Karaszewski, J. W. (1998). Immune consequences of stroke and cerebral palsy in adults. Journal of Neuroimmunology, 91, 113-120.
View publication via DOI: DOI:10.1016/S0165-5728(98)00157-X

Lemieux, A.M., Coe, C.L., & Ershler, W.B. (1996). Surgical and psychological stress differentially affect cytolytic responses in the aged female monkey. Brain, Behavior, and Immunity, 10, 27-43.
View publication via DOI: DOI:10.1016/S0889-1591(02)00099-5

Ershler, W.B., Coe, C.L., Gravenstein, S., Klopp, R.G., Meyer, M., & Houser, W.D. (1988). Aging and immunity in nonhuman primates, I. Effects of age and gender on cellular immune function in rhesus monkeys (Macaca mulatta). American Journal of Primatology, 15, 181-188.
View publication via DOI: DOI:10.1002/ajp.1350150210

Ershler, W.B., Coe, C.L., Laughlin, N., Klopp, R.G., Gravenstein, S., & Roecker, E.B. (1988). Aging and immunity in nonhuman primates. II. Lymphocyte response in thymosin-treated, middle-aged monkeys. Gerontology, 43, 142-146.
View publication via DOI: DOI:10.1093/geronj/43.5.B142

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