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Training Grant-
Biology of Aging

Leonelo Bautista

Leonelo E. Bautista

DrPH, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD
Associate Professor, Department of Population Health Sciences

Age related changes in blood pressure and hypertension

Special Topics Epidemiology: Cardiovascular Diseases (PHS 904) is an introductory course for students interested in cardiovascular research, prevention, or management. PHS 940-CV provides students with an overview of how cardiovascular diseases are diagnosed, what their impact on population health is, what factors increase their risk, what prevention tools are currently available, and what the main gaps in knowledge about these diseases are.

My main research interest resides in the identification of genetic, environmental, social and behavioral factors that influence the development of diseases and health related events in human populations. More specifically, I am interested in the identification of factors that influence the level of blood pressure and increase the risk of the developing arterial hypertension in the population and how the effect of these factors change with age. Factors associated with hypertension could eventually be used to indenfify high risk subjects, as therapeutic markers, and as target for the development of preventive and therapeutic interventions.

Representative Publications
Tedla, Y. G., & Bautista, L. E. (2017). Factors associated with false-positive self-reported adherence to antihypertensive drugs. Journal of Human Hypertension, 321(5), 320-326.
View publication via DOI: DOI:10.1038/jhh.2016.80

Tedla, Y. G., & Bautista, L. E. (2016). Drug side effect symptoms and adherence to antihypertensive medication. American Journal of Hypertension, 29(6), 772-779.
View publication via DOI: DOI:10.1093/ajh/hpv185

Tedla, Y. G., & Bautista, L. E. (2016). Response to "Antihypertensive drug-related side effects: Is it the unique indicator for nonadherence?". American Journal of Hypertension, 29(5), 663.
View publication via DOI: DOI:10.1093/ajh/hpw029

Wang, L., & Bautista, L. E. (2015). Serum bilirubin and the risk of hypertension. International Journal of Epidemiology, 44(1), 142-152.
View publication via DOI: DOI:10.1093/ije/dyu242

Miranda, J. J., Herrera, V. M., Chirinos, J. A., Gomez, L. F., Perel, P., Pichardo, R., . . . Bautista, L. E. (2013). Major cardiovascular risk factors in Latin America: a comparison with the United States. The Latin American Consortium of Studies in Obesity (LASO). PLoS One, 8(1), e54056.
View publication via DOI: DOI:10.1371/journal.pone.0054056

Bautista, L. E., Vera-Cala, L. M., Ferrante, D., Herrera, V. M., Miranda, J. J., Pichardo, R., . . . Casas, J. P. (2013). A 'polypill' aimed at preventing cardiovascular disease could prove highly cost-effective for use in Latin America. Health Affairs, 32(1), 155-164.
View publication via DOI: DOI:10.1377/hlthaff.2011.0948

Fan, C., Nieto, F.J., Bautista, L.E., & Fine, J.P. (2012). Vitamin D intake and cardiovascular mortality in the NHANES I Epidemiological Follow-up Study Cohort. Journal of Dietary Supplements, 9(2), 79-89.
View publication via DOI: DOI:10.3109/19390211.2012.682204

Bautista, L.E., Vera-Cala, L.M., Colombo, C., & Smith, P. (2012). Symptoms of Depression and Anxiety and Adherence to Antihypertensive Medication. American Journal of Hypertension, 25(4), 505-511.
View publication via DOI: DOI:10.1038/ajh.2011.256

Holmes, M.V., Newcombe, P., Hubacek, J.A., Sofat, R., Ricketts, S.L., Cooper, J., Breteler, M., Bautista, L.E., ... Casas JP. (2011). MTHFR genotype, homocysteine and stroke risk: Investigation of effect modification by population dietary folate based on meta-analysis of genetic studies and randomised clinical trials. The Lancet, 378(9791), 584-594.
View publication via DOI: DOI:10.1016/S0140-6736(11)60872-6

Vera-Cala, L.M., Orostegui, M., Valencia-Angel, L.I., Lopez, N., & Bautista, L.E. (2011). Accuracy of the Omron HEM-705 CP for Blood Pressure Measurement in Large Epidemiologic Studies. Arquivos Brasileiros de Cardiologia, 96:393-398.
View publication via DOI: DOI:10.1590/S0066-782X2011005000038

Chow, C.K., Islam, S., Bautista, L., Rumboldt, Z., Yusufali, A., Xie, C., ... Yusuf, S. (2011). Parental history and myocardial infarction risk across the world - The INTERHEART study. Journal of the America College of Cardiology, 57(5), 619-627.
View publication via DOI: DOI:10.1016/j.jacc.2010.07.054

Schmitz, K.J., Skinner, H.G., Bautista, L.E., Fingerlin, T.E., Langefeld, C.D., Hicks, P.J., Haffner, S.M., Bryer-Ash, M., Wagenknecht, L.E., Bowden, D.W., Norris, J.M., & Engelman, C.D. (2009). Association of 25-hydroxyvitamin D with blood pressure in predominately 25-hydroxyvitamin D deficient Hispanic and African Americans. American Journal of Hypertension, 22(8), 867-870.
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View publication via DOI: DOI:10.1038/ajh.2009.88

Bautista, L.E. (2009). Blood pressure-lowering effects of statins: Who benefits? Journal of Hypertension, 27(7), 1478-1484.
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View publication via DOI: DOI:10.1097/HJH.06013e32832b1e78

Bautista, L.E., Stein, J.H., Morgan, B.J., Stanton, N., Young, T., & Nieto, F.J. (2009). Association of blood and hair mercury with blood pressure and vascular reactivity. Wisconsin Medical Journal, 108(5), 250-252.

Bautista, L.E., Vargas, C.I., Orostegui, M., & Gamarra, G. (2008). Population based case-control study of renin-angiotensin system gene polymorphisms and hypertension among hispanics. J. Hypertens. Res., 31(3), 401-408.
View publication via DOI: DOI:10.1291/hypres.31.401

Bautista, L.E. (2008). Predictors of Persistence with Antihypertensive Therapy: Results from the NHANES. Am. J. Hypertens. 2008, 21, 183-188.
View publication via DOI: DOI:10.1038/ajh.2007.33

Herrera, V.M., Orostegui, M., Aguilera, X., Ferreccio, C., Silva, E., Clavell, E., Pichardo, R., Gonzalez, A., Casas, J.P., Lanas, F., Avezum, A., Bautista, L.E., Diaz, R., Luna, M., Islam, S., & Yusuf, S. (2007). Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study. Circulation, 115, 1067-1074.
View publication via DOI: DOI:10.1161/CIRCULATIONAHA.106.633552

Casas, J.P., Cavalleri, G.L., Bautista, L.E., Smeeth, L., Humphries, S., & Hingorani, A. (2006). Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease: A HuGE Review. Am. J. Epidemiol., 164(10), 921-935.
View publication via DOI: DOI:10.1093/aje/kwj302

Bautista, L.E. (2006). Association of periodontitis with blood pressure. Blood Pressure, 14, 38.
View publication via DOI: DOI:10.1080/08037050500356576

Hatzigeorgiou, C., Taylor, A.J., Feuerstein, I.M., Bautista, L., & O'Malley, P.G. (2006). Antioxidant vitamin intake and subclinical coronary atherosclerosis. Preventive Cardiology, 9, 75-81.
View publication via DOI: DOI:10.1111/j.1520-037X.2006.4424.x

Yusuf, S., Hawken, S., Ounpuu, S., Bautista, L., Franzosi, M.G., Commerford, P., Lang, C.C., Rumboldt, Z., Onen, C., Lisheng, L., Tanomsup, S., Razak, F., Sharma, A.M., Anand, S., on behalf of the INTERHEART Study Investigators. (2005). Obesity and the risk of myocardial infarction: a case-control study in 27,000 subjects from 52 countries. Lancet, 366, 1640-49.

Casas, JP, Bautista, LE, Smeeth, L, Sharma, P, & Hingorani, AD. (2005). Homocysteine and Stroke: "Mendelian randomization" provides further evidence for a causal link. Lancet, 365, 224-32.
View publication via DOI: DOI:10.1016/S0140-6736(05)17742-3

Bautista, L.E., Vera, L.M., Arenas, I.A., & Gamarra, G. (2005). Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension. J. Human Hypertens., 19, 149-154.
View publication via DOI: DOI:10.1038/sj.jhh.1001785

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