Untitled Document

Research

Leonelo E. Bautista

DrPH, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD
Assistant Professor, Department of Population Health Sciences
lebautista@wisc.edu
http://www.pophealth.wisc.edu/faculty/lbautista.html

Age related changes in blood pressure and hypertension

Special Topics Epidemiology: Cardiovascular Diseases (PHS 904) is an introductory course for students interested in cardiovascular research, prevention, or management. PHS 940-CV provides students with an overview of how cardiovascular diseases are diagnosed, what their impact on population health is, what factors increase their risk, what prevention tools are currently available, and what the main gaps in knowledge about these diseases are.

My main research interest resides in the identification of genetic, environmental, social and behavioral factors that influence the development of diseases and health related events in human populations. More specifically, I am interested in the identification of factors that influence the level of blood pressure and increase the risk of the developing arterial hypertension in the population and how the effect of these factors change with age. Factors associated with hypertension could eventually be used to indenfify high risk subjects, as therapeutic markers, and as target for the development of preventive and therapeutic interventions.

Representative Publications
Schmitz, K.J., Skinner, H.G., Bautista, L.E., Fingerlin, T.E., Langefeld, C.D., Hicks, P.J., Haffner, S.M., Bryer-Ash, M., Wagenknecht, L.E., Bowden, D.W., Norris, J.M., & Engelman, C.D. (2009). Association of 25-hydroxyvitamin D with blood pressure in predominately 25-hydroxyvitamin D deficient Hispanic and African Americans. American Journal of Hypertension, 22(8), 867-870.

Bautista, L.E., Vargas, C.I., Or�stegui, M., & Gamarra, G. (2008). Population based case-control study of renin-angiotensin system gene polymorphisms and hypertension among hispanics. J. Hypertens. Res., 31(3), 401-408.

Bautista, L.E. (2008). Predictors of Persistence with Antihypertensive Therapy: Results from the NHANES. Am. J. Hypertens. 2008, 21, 183-188.

Herrera, V.M., Or�stegui, M., Aguilera, X., Ferreccio, C., Silva, E., Clavell, E., Pichardo, R., Gonzalez, A., Casas, J.P., Lanas, F., Avezum, A., Bautista, L.E., Diaz, R., Luna, M., Islam, S., & Yusuf, S. (2007). Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study. Circulation, 115, 1067-1074.

Casas, J.P., Cavalleri, G.L., Bautista, L.E., Smeeth, L., Humphries, S., & Hingorani, A. (2006). Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease: A HuGE Review. Am. J. Epidemiol., 164(10), 921-935.

Bautista, L.E. (2006). Association of periodontitis with blood pressure. Blood Pressure, 14, 38.

Hatzigeorgiou, C., Taylor, A.J., Feuerstein, I.M., Bautista, L., & O�Malley, P.G. (2006). Antioxidant vitamin intake and subclinical coronary atherosclerosis. Preventive Cardiology, 9, 75-81.

Yusuf, S., Hawken, S., �unpuu, S., Bautista, L., Franzosi, M.G., Commerford, P., Lang, C.C., Rumboldt, Z., Onen, C., Lisheng, L., Tanomsup, S., Razak, F., Sharma, A.M., Anand, S., on behalf of the INTERHEART Study Investigators. (2005). Obesity and the risk of myocardial infarction: a case-control study in 27,000 subjects from 52 countries. Lancet, 366, 1640-49.

Casas, JP, Bautista, LE, Smeeth, L, Sharma, P, & Hingorani, AD. (2005). Homocysteine and Stroke: �Mendelian randomization� provides further evidence for a causal link. Lancet, 365, 224-32.

Bautista, L.E., Vera, L.M., Arenas, I.A., & Gamarra, G. (2005). Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension. J. Human Hypertens., 19, 149-154.

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