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Annual
COLLOQUIUM
ON AGING
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AGING NEWS:

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Training Grant-
Biology of Aging
:

Karen Cruickshanks

Karen J. Cruickshanks

Ph.D., University of Pittsburgh
Professor, Depts. of Ophthalmology and Visual Sciences and Population Health Sciences
cruickshanks@episense.wisc.edu
https://www.ophth.wisc.edu/directory/faculty/?person=cruickshanks
pophealth.wisc.edu/karen-cruickshanks


Epidemiology of Age-related Sensory Disorders; Epidemiology of Diabetes and its Complications

Age-related changes in sensory function (hearing, vision and olfaction, etc.) are common problems impacting quality of life and the ability to remain independent as people get older. For many of these age-related disorders, there are few effective treatments and little information available on how to prevent them from occurring. Using epidemiologic approaches, my research seeks to identify what factors (lifestyle, genetic and environmental) increase the risk of developing sensory disorders such as hearing, vision, and olfactory impairments or age-related macular degeneration. The ultimate goal is to identify intervention strategies to prevent these diseases, delay progression, or lessen the consequences of the disorders.

My research focuses on two longitudinal cohort studies, The Epidemiology of Hearing Loss Study and the Beaver Dam Offspring Study, which are supported by the National Institutes of Health. We re-examine the participants every five years to measure changes in sensory function, cognition and vascular health. The results of these studies have suggested that some cardiovascular risk factors, atherosclerosis and inflammation, may contribute to the risks of sensory and cognitive problems. We also have learned that baby-boomers and more recent generations are maintaining better sensory health than previous generations, which is strong evidence that these common chronic problems of aging can be prevented or delayed. Our group is studying people born in different time periods to help identify the factors which contribute to healthy aging.

Additional collaborations include the UK BioBank, Hispanic Community Health Study, Wisconsin Epidemiologic Study of Diabetic Retinopathy, Beaver Dam Eye Study and the Epidemiology of Diabetes Interventions and Complications (EDIC) study. The common theme is studying large groups of people recruited from the general population to understand how to prevent age-related disorders and increase healthy aging.



Representative Publications
Chen, Y., Cruickshanks, K. J., Nondahl, D., Schubert, C., Klein, R., & Klein, B. E. K. (2017). The relation between sleep disruption and cataract in a large population study. Ophthalmic Epidemiology. Advance online publication.
View publication via DOI: DOI:10.1080/09286586.2016.1259640

Wichmann, M. A., Cruickshanks, K. J., Carlsson, C. M., Chappell, R., Fischer, M. E., Klein, B. E., Klein, R., & Schubert, C. R. (2016). NSAID use and incident cognitive impairment in a population-based cohort. Alzheimer Disease and Associated Disorders, 30(2), 105-12.
View publication via DOI: DOI:10.1097/wad.0000000000000098

Fischer, M. E., Cruickshanks, K. J., Schubert, C. R., Pinto, A. A., Carlsson, C. M., Klein, B. E. K., Klein, R., & Tweed, T. S. (2016). Age-related sensory impairments and risk of cognitive impairment. Journal of the American Geriatrics Society, 64(10), 1981-1987.
View publication via DOI: DOI:10.1111/jgs.14308

Shubert, C. R., Fischer, M. E., Pinto, A. A., Klein, B. E. K., Klein, R., & Cruickshanks, K. J. (2016). Odor detection thresholds in a population of older adults. Laryngoscope. Advance online publication.
View publication via DOI: DOI:10.1002/lary.26457

Schubert, C. R., Fischer, M. E., Pinto, A. A., Klein, B. E. K., Klein, R., Tweed, T. S., & Cruickshanks, K. J. (2016). Sensory impairments and risk of mortality in older adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Advance online publication.
View publication via DOI: DOI:10.1093/gerona/glw036

Chopra, A., Jung, M., Kaplan, R. C., Appel, D. W., Dinces, E. A., Dhar, S., Zee, P. C., Gonzalez, F., Lee, D. J., Ramos, A. R., Hoffman, H. J., Redline, S., Cruickshanks, K. J., & Shah, N. A. (2016). Sleep apnea is associated with hearing impairment: The Hispanic Community Health Study/Study of Latinos. Journal of Clinical Sleep Medicine, 12(5), 719-26.
View publication via DOI: DOI:10.5664/jcsm.5804

Ryan, C. M., Klein, B. E. K., Lee, K. E., Cruickshanks, K. J., & Klein, R. (2016). Associations between recent severe hypoglycemia, retinal vessel diameters, and cognition in adults with type 1 diabetes. Journal of Diabetes and its Complications, 30(8), 1513-1518.
View publication via DOI: DOI:10.1016/j.jdiacomp.2016.08.010

Fischer, M. E., Cruickshanks, K. J., Nondahl, D. M., Klein, B. E. K., Klein, R., Pankow, J. S., Tweed, T. S., Dalton, D. S., & Paulsen, A. J. (2016). Dichotic digits test performance across the ages: Results from two large epidemiologic cohort studies. Ear and Hearing. Advance online publication.
View publication via DOI: DOI:10.1097/AUD.0000000000000386

Fischer, M.E., Schubert, C.R., Nondahl, D.M., Dalton, D.S., Huang, G.H., Keating, B.J., Klein, B.E.K., Klein, R., Tweed, T.S., & Cruickshanks, K.J. (2015). Subclinical Atherosclerosis and Increased Risk of Hearing Impairment. Atherosclerosis, 238(2), 344-9.
View publication via DOI: DOI:10.1016/j.atherosclerosis.2014.12.031

Cruickshanks, K. J., Dhar, S., Dinces, E., Fifer, R. C., Gonzalez, F., 2nd, Heiss, G., Hoffman, H. J., Lee, D. J., Newhoff, M., Tocci, L., Torre, P., 3rd, & Tweed, T. S. (2015). Hearing impairment prevalence and associated risk factors in the Hispanic Community Health study/Study of Latinos. JAMA Otolaryngology- Head & Neck Surgery, 141(7), 641-648.
View publication via DOI: DOI:10.1001/jamaoto.2015.0889

Dawes, P., Emsley, R., Cruickshanks, K. J., ... Fortnum, H., Edmondson-Jones, M., McCormack, A., & Munro, K. J. (2015). Hearing loss and cognition: The role of hearing AIDS, social isolation and depression. PLoS One, 10(3), e0119616.
View publication via DOI: DOI:10.1371/journal.pone.0119616

Schubert, C. R., Cruickshanks, K. J., Fischer, M. E., Klein, B. E., Klein, R., & Pinto, A. A. (2015). Inflammatory and vascular markers and olfactory impairment in older adults. Age and Ageing, 44(5), 878-882.
View publication via DOI: DOI:10.1093/ageing/afv075

Tremblay, K. L., Pinto, A., Fischer, M. E., Klein, B. E., Klein, R., Levy, S., Tweed, T. S., & Cruickshanks, K. J. (2015). Self-reported hearing difficulties among adults with normal audiograms: The Beaver Dam Offspring study. Ear and Hearing, 36(6), e290-299.
View publication via DOI: DOI:10.1097/aud.0000000000000195

Dawes, P., Cruickshanks, K. J., Fischer, M. E., Klein, B. E., Klein, R., & Nondahl, D. M. (2015). Hearing-aid use and long-term health outcomes: Hearing handicap, mental health, social engagement, cognitive function, physical health, and mortality. International Journal of Audiology, 54(11), 838-844.
View publication via DOI: DOI:10.3109/14992027.2015.1059503

Dawes, P., Cruickshanks, K. J., ... Fortnum, H., Edmondson-Jones, M., McCormack, A., & Munro, K. J. (2015). The effect of prenatal and childhood development on hearing, vision and cognition in adulthood. PLoS One, 10(8), e0136590.
View publication via DOI: DOI:10.1371/journal.pone.0136590

Klein, R., Myers, C. E., Lee, K. E., Paterson, A. D., Cruickshanks, K. J., Tsai, M. Y., Gangnon, R. E., & Klein, B. E. (2015). Oxidized low-density lipoprotein and the incidence of proliferative diabetic retinopathy and clinically significant macular edema determined from fundus photographs. JAMA Ophthalmology, 133(9), 1054-1061.
View publication via DOI: DOI:10.1001/jamaophthalmol.2015.2239

Schubert, C. R., Cruickshanks, K. J., Fischer, M. E., Klein, B. E., Klein, R., & Pinto, A. A. (2015). Inflammatory and vascular markers and olfactory impairment in older adults. Age and Ageing, 44(5), 878-882.
View publication via DOI: DOI:10.1093/ageing/afv075

Cruickshanks, K. J., Nondahl, D. M., Dalton, D. S., Fischer, M. E., Klein, B. E., Klein, R., Nieto, F. J., Schubert, C. R., & Tweed, T. S. (2015). Smoking, central adiposity, and poor glycemic control increase risk of hearing impairment. Journal of the American Geriatrics Society, 63(5), 918-924.
View publication via DOI: DOI:10.1111/jgs.13401

Klein, R., Myers, C. E., Lee, K. E., Paterson, A. D., Cruickshanks, K. J., Tsai, M. Y., Gangnon, R. E., & Klein, B. E. (2015). Oxidized low-density lipoprotein and the incidence of proliferative diabetic retinopathy and clinically significant macular edema determined from fundus photographs. JAMA Ophthalmology, 133(9), 1054-1061.
View publication via DOI: DOI:10.1001/jamaophthalmol.2015.2239

Fischer, M. E., Cruickshanks, K. J., Pinto, A., Klein, B. E. K., Klein, R., & Dalton, D. (2014). Hearing impairment and retirement. Journal of the American Academy of Audiology, 25(2), 164-170.
View publication via DOI: DOI:10.3766/jaaa.25.2.5.

Dawes, P., Fortnum, H., ... Emsley, R., Norman, P., Cruickshanks, K.J., Davis, A.C., Edmondson-Jones, M., McCormack, A., Lutman, M., & Munro, K.J. (2014). Hearing Disability in Middle Age: A population snapshot of 40-69 year olds in the UK. Ear and Hearing, 35(3), e44-51.
View publication via DOI: DOI:10.1097/AUD.0000000000000010

Tragante, V., Barnes, M.R., Ganesh, S.K., Lanktree, M.B., Guo, W., Franceschini, N., Cruickshanks, K.J., (...), Asselbergs, F.W., Munroe, P.B., & Keating, B.J. (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood pressure related loci. American Journal of Human Genetics, 94(3), 349-360.
View publication via DOI: DOI:10.1016/j.ajhg.2013.12.016

Paulsen, A.J., Cruickshanks, K.J., Fischer, M.E., Huang, G.H., Klein, B.E., Lien, R., & Dalton, D.S (2014). Dry eye in the Beaver Dam Offspring Study: Prevalence, risk factors, and health-related quality of life. American Journal of Ophthalmology, 7(4), 799-806.
View publication via DOI: DOI:10.1016/j.ajo.2013.12.023

Fischer, M.E., Cruickshanks, K.J., Schubert, C.R., Pinto, A., Huang, G.H., Klein, B.E.K., Klein, R., & Pankow, J. (2014). The Association of Taste with Change in Adiposity-related Health Measures. Journal of the Academy of Nutrition and Dietetics, 4(8), 1195-202.
View publication via DOI: DOI:10.1016/j.jand.2014.04.013

Dawes, P., Cruickshanks, K.J., ... Edmondson-jones, M., McCormack, A., Fortnum, H., & Munro, K.J. (2014). Cigarette smoking, passive smoking, alcohol consumption and hearing loss. Journal of the Association of Research in Otolaryngology, 5(4), 663-674.
View publication via DOI: DOI:10.1007/s10162-014-0461-0

Wichmann, M.A., Cruickshanks, K.J., Carlsson, C.M., Chappell, R., Fischer, M.E., Klein, B.E.K., Klein, R., Tsai, M.Y., & Schubert, C.R. (2014). Long-term systemic inflammation and cognitive impairment in a population-based cohort. Journal of the American Geriatrics Society, 2(9), 1683-1691.
View publication via DOI: DOI:10.1111/jgs.12994

Dawes, P., Dickinson, C., Emsley, R., Bishop, P., Cruickshanks, K.J., McCormack, A., Fortnum, H., ... Norman, P., Munro, K. (2014). Vision impairment and dual sensory problems in middle age. Ophthalmic and Physiological Optics: The journal of the British College of Ophthalmic Opticians (Optometrists), 4(4), 479-88.
View publication via DOI: DOI:10.1111/opo.12138

Schubert, C.R., Cruickshanks, K.J., Fischer, M.E., Huang, G., Klein, R., Tsai, M.Y., & Pinto, A. (2014). Carotid Intima Media Thickness, Atherosclerosis and 5-year Decline in Odor Identification: The Beaver Dam Offspring Study. The Journal of Gerontology. Epub ahead of print.
View publication via DOI: DOI:10.1093/gerona/glu158

Fischer, M.E., Cruickshanks, K.J., Pankow, J.S., Pankratz, N., Schubert, C.R., Huang, G.H., Klein, B.E.K., Klein, R., & Pinto, A. (2014). The Associations Between 6-n-propylthiouracil (PROP) Intensity and Taste Intensities Differ by TAS2R38 Haplotype. Journal of Nutrigenetics Nutrigenomics.
View publication via DOI: DOI:10.1159/000371552

Klein, R., Meyers, C.E., Cruickshanks, K.J., Gangnon, R.E., Danforth, L.G., Sivakumaran, T.A., Iyengar, S.K., Twai, M.Y., & Klein, B.E. (2014). Markers of inflammation, oxidative stress, and endothelial dysfunction and the 20-year cumulative incidence of early age-related macular degeneration: The Beaver Dam Eye Study. JAMA Ophthalmology, 132(4), 446-55.
View publication via DOI: DOI:10.1001/jamaophthalmol.2013.7671

Cruickshanks, K.J., Nondahl, D.M., Dalton, D.S., Rischer, M.E., Klein, B.E.K., Klein, R., Nieto, J.F., Schubert, C.R., & Tweed, T.S. (2014). Smoking, Central Adiposity, and Poor Glycemic Control Increase Risk of Hearing Impairment. Journal of the American Geriatric Society, Advanced online publication.
View publication via DOI: DOI:10.2337/dc10-2161

Klein, B.E.K., Howard, K.P., Iyengar, S.K., Sivakumaran, T.A., Meyers, K., Cruickshanks, K.J., & Klein, R. (2014). Sunlight exposure, pigmentation, and incident age-related macular degeneration. Investigative Ophthalmology & Visual Science, 55(9):5855-5861.
View publication via DOI: DOI:10.1167/iovs.14-14602

LeCaire, T. J., Palta, M., Klein, R., Klein, B. E., & Cruickshanks, K. J. (2013). Assessing progress in retinopathy outcomes in type 1 diabetes: Comparing findings from the Wisconsin diabetes registry Study and the Wisconsin epidemiologic Study of diabetic retinopathy. Diabetes Care, 36(3), 631-637.
View publication via DOI: DOI:10.2337/dc12-0863

Wichmann, M. A., Cruickshanks, K. J., Nondahl, D. M., Chappell, R., Klein, B. E., Klein, R., & Fischer, M. E. (2013). Changes in environmental tobacco smoke exposure: The beaver dam experience. WMJ, 112(2), 53-57.

Nash, S. D., Cruickshanks, K. J., Huang, G.-H., Klein, B. E. K., Klein, R., Nieto, F. J., & Tweed, T. S. (2013). Unmet hearing health care needs: The Beaver Dam Offspring Study. American Journal of Public Health, 103(6), 1134-1139.
View publication via DOI: DOI:10.2105/AJPH.2012.301031

Zhong, W., Cruickshanks, K. J., Schubert, C. R., Carlsson, C. M., Chappell, R. J., Klein, B. E. K., Klein, R., Acher, C. W. (2013). Pulse wave velocity and cognitive function in older adults. Alzheimer Disease and Associated Disorders. Advance online publication.
View publication via DOI: DOI:10.1097/WAD.0b013e3182949f06

Fischer, M. E., Cruickshanks, K. J., Schubert, C. R., Pinto, A., Klein, B. E. K., Klein, R., . . . Snyder, D. J. (2013). Taste intensity in the Beaver Dam Offspring Study. Laryngoscope, 123(6), 1399-1404.
View publication via DOI: DOI:10.1002/lary.23894

Nash, S. D., Cruickshanks, K. J., Zhan, W., Tsai, M. Y., Klein, R., Chappell, R., . . . Klein, B. E. K., . . . Tweed, T. S. (2013). Long-term assessment of systemic inflammation and the cumulative incidence of age-related hearing impairment in the epidemiology of hearing loss study. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Advance online publication.
View publication via DOI: DOI:10.1093/gerona/glt075

Nash, S. D., Cruickshanks, K. J., Klein, R., Klein, B. E., Nieto, F. J., Chappell, R., . . . Tsai, M. Y. (2013). Long-term variability of inflammatory markers and associated factors in a population-based cohort. Journal of the American Geriatrics Society, 61(8), 1269-1276.
View publication via DOI: DOI:10.1111/jgs.12382

Nondahl, D. M., Cruickshanks, K. J., Wiley, T. L., Tweed, T. S., & Dalton, D. S. (2013). 16-year change in acoustic admittance measures among older adults: Data from a population-based study. Journal of Speech, Language, and Hearing Research. Advance online publication.
View publication via DOI: DOI:10.1044/1092-4388(2013/12-0381)

Schubert, C. R., Cruickshanks, K. J., Fischer, M. E., Huang, G. H., Klein, R., Pankratz, N., . . . Nondahl, D. M. (2013). Odor identification and cognitive function in the Beaver Dam Offspring Study. Journal of Clinical and Experimental Neuropsychology, 35(7), 669-676.
View publication via DOI: DOI:10.1080/13803395.2013.809701

Schubert, C. R., Cruickshanks, K. J., Nondahl, D. M., Klein, B. E. K., Klein, R., & Fischer, M. (2013). Association of Exercise With Lower Long-term Risk of Olfactory Impairment in Older Adults. JAMA Otolaryngology - Head & Neck Surgery, 139(10), 1061-1066.
View publication via DOI: DOI:10.1001/jamaoto.2013.4759

Fischer, M. E., Cruickshanks, K. J., Schubert, C. R., Pinto, A., Klein, R., Pankratz, N., . . . Huang, G.-H. (2013). Factors related to fungiform papillae density: The Beaver Dam Offspring Study. Chemical Senses, 38(8), 669-677.
View publication via DOI: DOI:10.1093/chemse/bjt033

Klein, R., Cruickshanks, K. J., Myers, C. E., Sivakumaran, T. A., Iyengar, S. K., Meuer, S. M., . . . Klein, B. E. K. (2013). The relationship of atherosclerosis to the 10-year cumulative incidence of age-related macular degeneration: The Beaver Dam studies. Ophthalmology, 120(5), 1012-1019.
View publication via DOI: DOI:10.1016/j.ophtha.2012.11.003

Nash, S.D., Cruickshanks, K.J., Klein, R., Klein, B.E.K., Nieto, F.J., Ryff, C.D., ... Acher, C.W. (2012). Response to "Socioeconomic status and subclinical atherosclerosis in older adults," by Drs. Karbakhsh and Tabrizchi. Preventative Medicine, 54(2):176.
View publication via DOI: DOI:10.1016/j.ypmed.2011.11.008

Schubert, C.R., Klein, B.E.K., Klein, R., Cruickshanks, K.J., Fischer, M.E., Huang, G.H., Pankow, J.S., & Nondahl, D.M. (2012). Olfactory impairment in an adult population: the Beaver Dam Offspring Study. Chemical Senses, 37(4), 325-34.
View publication via DOI: DOI:10.1093/chemse/bjr102

Fischer, M.E., Cruickshanks, K.J., Pinto, A.A., Schubert, C.R., Klein, B.E.K., Klein, R., ... Keating BJ. (2012). Intensity of salt taste and prevalence of hypertension are not related in the Beaver Dam Offspring Study. Chemosensory Perception, 5(2), 139-145.
View publication via DOI: DOI:10.1007/s12078-012-9118-8

Zhong, W., Cruickshanks, K. J., Schubert, C. R., Acher, C. W., Carlsson, C. M., Klein, B. E. K., . . . Chappell, R. J. (2012). Carotid atherosclerosis and 10-year changes in cognitive function. Atherosclerosis, 224(2), 506-510.
View publication via DOI: DOI:10.1016/j.atherosclerosis.2012.07.024

Nondahl, D.M., Cruickshanks, K.J., Huang, G.H., Klein, B.E.K., Klein, R., Tweed, T.S., & Zhan, W. (2012). Generational differences in the reporting of tinnitus. Ear & Hearing, 33(5), 640-644.
View publication via DOI: DOI:10.1097/AUD.0b013e31825069e8

Nondahl, D.M., Tweed, T.S., Cruickshanks, K.J., Wiley, T.L., & Dalton, D.S. (2012). Aging and the 4 k Hz air-bone gap. Journal of Speech, Language, and Hearing Research, 55, 1128-1134.
View publication via DOI: DOI:10.1044/1092-4388(2011/11-0204)

Cruickshanks, K.J., & Wichmann, M.A. (2012). Hearing impairment and other health conditions in older adults: Chance associations or opportunities for prevention? Seminars in Hearing, 33(3), 217-224.
View publication via DOI: DOI:10.1055/s-0032-1315720

Humes, L. E., Dubno, J. R., Gordon-Salant, S., Lister, J. J., Cacace, A. T., Cruickshanks, K. J., . . . Wingfield, A. (2012). Central presbycusis: A review and evaluation of the evidence. Journal of the American Academy of Audiology, 23(8), 635-666.
View publication via DOI: DOI:10.3766/jaaa.23.8.5

Asselbergs, F. W., Guo, Y., van Iperen, E. P. A., Sivapalaratnam, S., Tragante, V., Lanktree, M. B., . . . Cruickshanks, K. J., . . . Drenos, F. (2012). Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. The American Journal of Human Genetics, 91(5), 823-838.
View publication via DOI: DOI:10.1016/j.ajhg.2012.08.032

Obasi, C. N., Cruickshanks, K. J., Nondahl, D. M., Klein, B. E. K., Klein, R., Nieto, F. J., . . . Chappell, R. (2012). Association of biomarkers for inflammation, endothelial dysfunction and oxidative stress with cognitive impairment: The epidemiology of hearing loss Study. Oxidants and Antioxidants in Medical Science, 1(3), 169-173.
View publication via DOI: DOI:10.5455/oams.031212.br.004

Nash, S.D., Cruickshanks, K.J., Klein, R., Klein, B.E.K., Nieto, F.J., Ryff, C.D., ... Acher, C.W. (2011). Socioeconomic status and subclinical atherosclerosis in older adults. Preventative Medicine, 52(3-4), 208-212.
View publication via DOI: DOI:10.1016/j.ypmed.2010.12.009

Schubert, C.R., Cruickshanks, K.J., Klein, B.E.K., Klein, R., & Nondahl, D.M. (2011). Olfactory impairment in older adults: 5-year incidence and risk factors. Laryngoscope, 121(4), 873-878.
View publication via DOI: DOI:10.1002/lary.21416

Nondahl, D.M., Cruickshanks, K.J., Huang, G.H., Klein, B.E.K., Klein, R., Nieto, F.J., & Tweed, T.S. (2011). Tinnitus and its risk factors in the Beaver Dam Offspring Study. International Journal of Audiology, 50(5), 313-20.
View publication via DOI: DOI:10.3109/14992027.2010.551220

Sabanayagam, C., Shankar, A., Klein, B.E.K., Lee, K.E., Muntner, P., Nieto, F.J., Tsai, M.Y., Cruickshanks, K.J., ... Klein R. (2011). Bidirectional association of retinal vessel diameters and estimated GFR decline: the Beaver Dam CKD study. American Journal of Kidney Diseases, 57(5), 682-91.
View publication via DOI: DOI:10.1053/j.ajkd.2010.11.025

Nash, S.D., Cruickshanks, K.J., Klein, R., Klein, B.E.K., Nieto, F.J., Huang, G.H., Pankow, J.S., & Tweed, T.S. (2011). The prevalence of hearing impairment and associated risk factors: the Beaver Dam Offspring Study. Archives of Otolaryngology - Head & Neck Surgery. 2011; 137(5):432-439.
View publication via DOI: DOI:10.1001/archoto.2011.15

Fischer, M.E., Cruickshanks, K.J., Wiley, T.L., Klein, B.E.K., Klein, R., & Tweed, T.S. (2011). Determinants of hearing aid acquisition in older adults. American Journal of Public Health, 101(8), 1449-1455.
View publication via DOI: DOI:10.2105/AJPH.2010.300078

Zhan, W., Cruickshanks, K.J., Klein, B.E.K., Klein, R., Huang, G.H., Pankow, J.S., Gangnon, R., & Tweed, T.S. (2011). Modifiable determinants of hearing impairment in adults. Preventative Medicine, 53(4-5), 338-42.
View publication via DOI: DOI:10.1016/j.ypmed.2011.08.012

Zhong, W., Cruickshanks, K.J., Huang, G.H., Klein, B.E.K., Klein, R., Nieto, F.J., Pankow, J.S., & Schubert, C.R. (2011). Carotid atherosclerosis and cognitive function in midlife: the Beaver Dam Offspring Study. Atherosclerosis, 219(1), 330-333.
View publication via DOI: DOI:10.1016/j.atherosclerosis.2011.07.013

Shankar, A., Sun, L., Klein, B.E.K., Lee, K.E., Muntner, P., Nieto, F.J., Tsai, M.Y., Cruickshanks, K.J. ... Klein, R. (2011). Markers of inflammation predict the long-term risk of developing chronic kidney disease: a population-based cohort study. Kidney International, 80(11), 1231-1238.
View publication via DOI: DOI:10.1038/ki.2011.283

Cruickshanks, K.J., Nondahl, D.M., Tweed, T.S., Wiley, T.L., Klein, B.E.K., Klein, R., Chappell, R., Dalton, D.S., & Nash, S.D. (2010). Education, occupation, noise exposure history and the 10-year cumulative incidence of hearing impairment in older adults. Hearing Research, 264(1-2), 3-9.
View publication via DOI: DOI:10.1016/j.heares.2009.10.008

Zhan, W., Cruickshanks, K.J., Klein, B.E.K., Klein, R., Huang, G.H., Pankow, J.S., Gangnon, R.E., & Tweed, T.S. (2010). Generational differences in the prevalence of hearing impairment in older adults. American Journal of Epidemiology, 171(2), 260-266.
View publication via DOI: DOI:10.1093/aje/kwp370

Krantz, E.M., Cruickshanks, K.J., Klein, B.E.K., Klein, R., Huang, G.H., & Nieto, F.J. (2010). Measuring refraction in adults in epidemiological studies. Archives of Ophthalmology, 128(1), 88-92.
View publication via DOI: DOI:10.1001/archopthalmol.2009.349

Klein, R., Cruickshanks, K.J., Nash, S.D., Krantz, E., Nieto, F.J., Huang, G.H., Pankow, J.S., & Klein, B.E.K. (2010). The prevalence of age-related macular degeneration and associated risk factors. Archives of Ophthalmology, 128(6), 750-758.
View publication via DOI: DOI:10.1001/archophthalmol.2010.92

Shankar, A., Lee, K.E., Klein, B.E.K., Coresh, J., Muntner, P., Brazy, P.C., Cruickshanks, K.J., Nieto, F.J., Danforth, L.G., Schubert, C.R., Tsai, M.Y., & Klein, R. (2010). Estimating glomerular filtration rate in a population-based study. Vascular Health and Risk Management, 6, 619-27.
View publication via DOI: DOI:10.2147/VHRM.S11269

Nondahl, D.M., Cruickshanks, K.J., Wiley, T.L., Klein, B.E.K., Klein, R., Chappell, R., & Tweed, T.S. (2010). The ten-year incidence of tinnitus among older adults. International Journal of Audiology, 49(8), 580-585.
View publication via DOI: DOI:10.3109/14992021003753508

Klein, B.E.K., Lee, K.E., Danforth, L.G., Schaich, T.M., Cruickshanks, K.J., & Klein R. (2010). Selected sun-sensitizing medications and incident cataract. Archives of Ophthalmology, 128(8), 959-963.
View publication via DOI: DOI:10.1001/archophthalmol.2010.138

Zhong, W., Cruickshanks, K.J., Schubert, C.R., Nieto, F.J., Huang, G.H., Klein, B.E.K., & Klein, R. (2010). Obesity and depression symptoms in the Beaver Dam Offspring Study population. Depression and Anxiety, 27(9), 846-51.
View publication via DOI: DOI:10.1002/da.20666

Fischer, M.E., Cruickshanks, K.J., Klein, B.E.K., Klein, R., Schubert, C.R., & Wiley, T.L. (2009). Multiple sensory impairment and quality of life. Ophthalmic Epidemiology, 16(6), 346-353.
View publication via DOI: DOI:10.3109/09286580903312236

Raynor, L.A., Pankow, J.S., Miller, M.B., Huang, G.H., Dalton, D., Klein, R., Klein, B.E.K., & Cruickshanks, K.J. (2009). Familial aggregation of age-related hearing loss in an epidemiological study of older adults. American Journal of Audiology, 18(2), 114-118.
View publication via DOI: DOI:10.1044/1059-0889(2009/08-0035)

Schubert, C.R., Cruickshanks, K.J., Murphy, C., Huang, G.H., Klein, B.E.K., Klein, R., Nieto, F.J., Pankow, J.S., & Tweed, T.S. (2009). Olfactory impairment in adults: The Beaver Dam experience. Annals of the New York Academy of Sciences, 1170, 531-536.
View publication via DOI: DOI:10.1111/j.1749-6632.2009.04102.x

Cruickshanks, K.J. (2009). Population-based epidemiologic studies of aging: the contributions of a Wisconsin community. WMJ, 108(5), 271-272.

Hoffman, H.J., Cruickshanks, K.J., Davis, B. (2009). Perspectives on population-based epidemiological studies of olfactory and taste impairment. Annals of the NY Academy of Science, 1170, 514-530.
View publication via DOI: DOI:10.1111/j.1749-6632.2009.04597.x

Nondahl, D.M., Shi, X., Cruickshanks, K.J., Dalton, D.S., Tweed, T.S., Wiley, T.L., Carmichael, L.L. (2009). Notched audiograms and noise exposure history in older adults. Ear and Hearing, 30(6), 696-703.
View publication via DOI: DOI:10.1097/AUD.0b013e3181b1d418

Carlsson, C.M., Nondahl, D.M., Klein, B.E., McBride, P.E., Sager, M.A., Schubert, C.R., Klein, R., & Cruickshanks, K.J. (2009). Increased atherogenic lipoproteins are associated with cognitive impairment: effects of statins and subclinical atherosclerosis. Alzheimer Disease and Associated Disorders, 23(1), 11-17.
View publication via DOI: DOI:10.1097/WAD.0b013e3181850188

Klein, R., Knudtson, M.D., Cruickshanks, K.J., & Klein, B.E.K. (2008). Further observations on the association between smoking and the long-term incidence and progression of age-related macular degeneration. Archives of Ophthalmology, 126(1), 115-121.
View publication via DOI: DOI:10.1001/archopht.126.1.115

Trentham-Dietz, A., Sprague, B.L., Klein, R., Klein, B.E.K., Cruickshanks, K.J., Fryback, D.G., & Hampton, J.M. (2008). Health-related quality of life before and after a breast cancer diagnosis. Breast Cancer Res. Treat., 109(2), 379-87.
View publication via DOI: DOI:10.1007/s10549-007-9653-1

Schubert, C.R., Carmichael, L.L., Murpy, C., Klein, B.E.K., Klein, R., & Cruickshanks, K.J. (2008). Olfaction and the 5-year incidence of cognitive impairment in an epidemiologic study of older adults. J. Am. Geriatr. Soc., 56, 1517-21. PMID: 18662205.
View publication via DOI: DOI:10.1111/j.1532-5415.2008.01826.x

Sprague, B.L., Trentham-Dietz, A., Klein, B.E.K., Klein, R., Cruickshanks, K.J., Lee, K.E., & Hampton, J.M. (2008). Physical activity, white blood cell count, and lung cancer risk in a prospective cohort study. Cancer Epidemiol. Biomarkers Prev., 17(10), 2714-22. PMID: 18843014.
View publication via DOI: DOI:10.1158/1055-9965.EPI-08-0042

Nondahl, D.M., Cruickshanks, K.J., Dalton, D.S., Klein, B.E.K., Klein, R., Schubert, C.R., Tweed, T.S., & Wiley, T.L. (2007). The impact of tinnitus on quality of life in older adults. J. Am. Acad. Audiol., 18(3), 259-268.
View publication via DOI: DOI:10.3766/jaaa.18.3.7

Nondahl, D.M., Cruickshanks, K.J., Dalton, D.S., Klein, B.E.K., Klein, R., Tweed, T.S., & Wiley, T.L. (2006). The use of hearing protection by older adults during recreational noise exposure. Noise and Health, 8, 147-153.
View publication via DOI: DOI:10.4103/1463-1741.34702

Nondahl, D.M., Klein, B.E., Klein, R., Cruickshanks, K.J., Tweed, T.S., & Wiley, T.L. (2005). Factors predicting severity of tinnitus: A population-based assessment. J. Am. Acad. Audiol., 16, 196; author reply 197.

Puent, B.D., Klein, B.E.K., Klein, R., Cruickshanks, K.J., & Nondahl, D.M. (2005). Factors related to vision care in an older adult cohort. Optom. Vis. Sci., 82, 612-616.

Torre, P.3rd, Cruickshanks, K.J., Klein, B.E., Klein, R., & Nondahl, D.M. (2005). The association between cardiovascular disease and cochlear function in older adults. J. Speech Lang. Hear. Res., 48(2), 473-81.
View publication via DOI: DOI:10.1044/1092-4388(2005/032)

Knudtson, M.D., Klein, B.E., Klein, R., Cruickshanks, K.J., & Lee, K.E. (2005). Age-related eye disease, quality of life, and functional activity. Arch. Ophthalmol., 123, 807-814.
View publication via DOI: DOI:10.1097/01.ieb.0000181127.17048.30

Klein, R., Klein, B.E.K., Moss, S.E., Wong, T.Y., Hubbard, L., Cruickshanks, K.J., & Palta, M. (2004). The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy. XIX: The Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch Ophthalmol., 122(1), 76-83.
View publication via DOI: DOI:10.1001/archopht.122.1.76

Tomany, S.C., Cruickshanks, K.J., Klein, R., Klein, B.E.K., & Knudtson, M.D. (2004). Sunlight and the 10-year incidence of age-related maculopathy: The Beaver Dam Eye Study. Arch. Ophthalmol., 122(5), 750-757.
View publication via DOI: DOI:10.1001/archopht.122.5.750

Klein, B.E.K., Klein, R., McBride, P.E., Cruickshanks, K.J., Palta, M., Knudtson, M.D., Moss, S.E., & Reinke, J.O. (2004). Cardiovascular disease, mortality, and retinal microvascular characteristics in type 1 diabetes Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch. Intern. Med., 164(17), 1917-1924.
View publication via DOI: DOI:10.1001/archinte.164.17.1917

Nondahl, D.M., Cruickshanks, K.J., Dalton, D.S., Schubert, C.R., Klein, B.E.K., Klein, R., & Tweed, T.S. (2004). Serum cotinine and incident hearing loss: A case/control study. Arch. Otolaryngol.--Head & Neck Surg., 130(11), 1260-1264.
View publication via DOI: DOI:10.1001/archotol.130.11.1260

Klein, B.E.K., Moss, S.E., Klein, R., Lee, K.E., & Cruickshanks, K.J. (2003). Associations of visual function with physical outcomes and limitations five years later in an older population: The Beaver Dam Eye Study. Ophthalmology, 110, 644-650.
View publication via DOI: DOI:10.1016/S0161-6420(02)01935-8

Klein, R., Klein, B.E.K., Tomany, S.C., & Cruickshanks, K.J. (2003). The association of cardiovascular disease with the long-term incidence of age-related maculopathy: The Beaver Dam Eye Study. Ophthalmology, 110(4), 636-643.
View publication via DOI: DOI:10.1016/S0161-6420(02)01448-3

Klein, R., Klein, B.E.K., Tomany, S.C., & Cruickshanks, K.J. (2003). Association of emphysema, gout, and inflammatory markers with the long-term incidence of age-related maculopathy. Arch. Ophthalmol., 121(5), 674-678.
View publication via DOI: DOI:10.1001/archopht.121.5.674

Klein, R., Klein, B.E.K., Tomany, S.C., Danforth, L.G., & Cruickshanks, K.J. (2003). Relation of statin use to the 5-year incidence and progression of age-related maculopathy. Arch. Ophthalmol., 121(8), 1151-1155.
View publication via DOI: DOI:10.1001/archopht.121.8.1151

Cruickshanks, K.J., Tweed, T.S., Wiley, T.L., Klein, B.E.K., Klein, R., Chappell, R., Nondahl, D.M., & Dalton, D.S. (2003). The 5-year incidence and progression of hearing loss: The Epidemiology of Hearing Loss Study. Arch Otolaryngol Head Neck Surg., 129(10), 1041-46.
View publication via DOI: DOI:10.1001/archotol.129.10.1041

Klein, R., Klein, B.E.K., Moss, S.E., Wong, T.Y., Hubbard, H., Cruickshanks, K.J., & Palta, M. (2003). Retinal vascular abnormalities in persons with type 1 diabetes: The Wisconsin Epidemiological Study of Diabetic Retinopathy XVIII. Ophthalmology, 110, 2118-2125.
View publication via DOI: DOI:10.1016/S0161-6420(03)00863-7

Mitchell, J.L., Cruickshanks, K.J., Klein, B.E.K., Palta, M., & Nondahl, D.M. (2003). Postmenopausal hormone therapy and its association with cognitive impairment. Arch Intern Med., 163(20), 2485-2490.
View publication via DOI: DOI:10.1001/archinte.163.20.2485

Dalton, D.S., Cruickshanks, K.J., Klein, B.E.K., Klein, R., Wiley, T.L., & Nondahl, D.M. (2003). The impact of hearing loss on quality of life in older adults. Gerontologist, 43(5), 661-8.
View publication via DOI: DOI:10.1093/geront/43.5.661

Nondahl, D.M., Cruickshanks, K.J., Wiley, T.L., Klein, R., Klein, B.E., & Tweed, T.S. (2003). Comment on tinnitus in older adults from the Blue Mountains Study by Sindhusade et al and comparison with tinnitus data from the Epidemiology of Hearing Loss Study. Int. J. Audiol., 43, 60.

Nondahl, D.M., Cruickshanks, K.J., Klein, R., Klein, B.E.K., Wiley, T.L., Tweed, T.S., & Pasic, T.R. (2002). Prevalence and 5- year incidence of tinnitus among older adults: The Epidemiology of Hearing Loss Study. J. Am. Acad. Audiol., 13, 323-331.

Murphy, C., Schubert, C.R., Cruickshanks, K.J., Klein, B.E.K., Klein, R., & Nondahl, D.M. (2002). Prevalence of olfactory impairment in older adults: Results of an epidemiological study. JAMA, 288(18), 2307-2312.
View publication via DOI: DOI:10.1001/jama.288.18.2307

Cruickshanks, K.J., Klein, R., Klein, B.E.K., & Nondahl, D.M. (2001). Sunlight and the 5-yr incidence of early age-related maculopathy: The Beaver Dam Eye Study. Arch Ophthalmol., 119(2), 246-250.
View publication via DOI: DOI:10-1001/pubs.Ophthalmol.-ISSN-0003-9950-119-2-eeb00005

Dalton, D.S., Cruickshanks, K.J., Wiley, T.L., Klein, B.E.K., Klein, R., & Tweed, T.S. (2001). Association of leisure time noise exposure and hearing loss. Audiology, 40, 1-9.

Rubin, G., & Cruickshanks, K.J. (2000). Sensory impairment in women. In M.B. Golman, & M.C. Hatch (Eds.), Women and health. San Diego: Academic Press.

Cruickshanks, K.J., Fryback, D.G., Nondahl, D.M., Robinson, N., Keesey, U., Dalton, D.S., Robertson, D.M., Chandra, et al. (1999). Treatment choice and quality of life in patients with choroidal melanoma. Arch. Ophthalmol., 117(4), 461-467.
View publication via DOI: DOI:10.1001/archopht.117.4.461

Klein, R., Klein, B.E.K., Jensen, S.C., Mares-Perlman, J.A., Cruickshanks, K.J., & Palta, M. (1999). Age-related maculopathy in a multiracial United States population: The National Health and Nutrition Examination Survey III. Ophthalmology, 106, 1056-1065.
View publication via DOI: DOI:10.1016/S0161-6420(99)90255-5

Cruickshanks, K.J., Klein, R., Klein, B.E.K., Wiley, T.L., Nondahl, D.M., & Tweed, T.S. (1998). Cigarette smoking and hearing loss: The Epidemiology of Hearing Loss Study. JAMA, 279(21), 1715-1719.
View publication via DOI: DOI:10.1001/jama.279.21.1715

Popelka, M.M., Cruickshanks, K.J., Wiley, T.L., Tweed, T.S., Klein, B.E.K., & Klein, R. (1998). Low prevalence of hearing aid use among older adults with hearing loss: The Epidemiology of Hearing Loss Study. J. Am. Geriatr. Soc., 46, 1075-1078.

Cruickshanks, K.J., Wiley, T.L., Tweed, T.S., Klein, B.E.K., Klein, R., Mares- Perlman, J.A., & Nondahl, D.M. (1998). Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin: The Epidemiology of Hearing Loss Study. Am. J. Epidemiol., 148(9), 879-886.

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