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Annual
COLLOQUIUM
ON AGING
:

Event Speakers

IOA Newsletter,
AGING NEWS:

Cover of Aging News

MIDUS
Newsletters
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MIDUS Inequality newsletter cover

Training Grant-
Biology of Aging
:

Barbara Bendlin

Barbara B. Bendlin

Ph.D., University of Arizona, Tucson
Associate Professor, Dept. of Medicine- Geriatrics & Adult Development
bbb@medicine.wisc.edu
http://www.brainmap.wisc.edu/people/3-BB-Bendlin


Cognitive Brain Aging and Alzheimer's Disease

Dr. Bendlin is a cognitive neuroscientist focused on understanding the brain and cognitive changes that occur in aging. She is especially interested in determining the very earliest brain changes that occur in Alzheimer's disease, and determining if there are risk factors for the disease that can be modified to promote healthier aging. Dr. Bendlin's NIH funded studies use brain imaging (magnetic resonance imaging and positron emission tomography) in combination with cerebrospinal fluid analysis to identify early brain changes in Alzheimer's, including axonal and myelin alteration. She is also studying the time course of inflammation in response to amyloid pathology, to determine how the immune response in Alzheimer's may either protect the brain or promote neuronal loss. A large part of her research work is also focused on understanding how metabolic risk factors such as diabetes, insulin resistance, and metabolic syndrome, impact neural health and cognition.



Representative Publications
Law, L. L., Schultz, S. A., Boots, E. A., Einerson, J. A., Dougherty, R. J., Oh, J. M., Korcarz, C. E., Edwards, D. F., ... Bendlin, B. B., Carlsson, C. M., Asthana, S., Hermann, B. P., Sager, M. A., Johnson, S. C., ... & Okonkwo, O. C. (2017). Chronotropic response and cognitive function in a cohort at risk for Alzheimer's disease. Journal of Alzheimer's Disease, 56(1), 351-359.
View publication via DOI: DOI:10.3233/jad-160642

Dean, D. C. I., Hurley, S. A., Kecskemeti, S. R., O'Grady, P., Canda, C., Davenport-Sis, N. J., ... Asthana, S., Sager, M. A., Johnson, S. C., Alexander, A., & Bendlin, B. B. (2017). Association of amyloid pathology with myelin alteration in preclinical Alzheimer's disease. JAMA Neurology, 74(1), 41-49.
View publication via DOI: DOI:10.1001/jamaneurol.2016.3232

Dougherty, R. J., Schultz, S. A., Boots, E. A., Ellingson, L. D., Meyer, J. D., Van Riper, S., Stegner, A. J., Edwards, D. F., ... Bendlin, B. B., Asthana, S., ... Sager, M. A., ... Johnson, S. C., Okonkwo, O. C., & Cook, D. B. (2017). Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease. Brain and Behavior. Advance online publication.
View publication via DOI: DOI:10.1002/brb3.625

Darst, B. F., Koscik, R. L., Racine, A. M., Oh, J. M., Krause, R. A., Carlsson, C. M., ... Bendlin, B. B., Okonkwo, O. C., ... Sager, M. A., Asthana, S., Johnson, S. C., & Engelman, C. D. (2017). Pathway-specific polygenic risk scores as predictors of amyloid-beta deposition and cognitive function in a sample at increased risk for Alzheimer's disease. Journal of Alzheimer's Disease, 55(2), 473-484.
View publication via DOI: DOI:10.3233/jad-160195

Clark, L. R., Racine, A. M., Koscik, R. L., Okonkwo, O. C., Engelman, C. D., Carlsson, C. M., Asthana, S., Bendlin, B. B., ... Sager, M. A., Christian, B. T., & Johnson, S. C. (2016). Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin registry for Alzheimer's prevention study. Alzheimer's & Dementia, 12(7), 805-814.
View publication via DOI: DOI:10.1016/j.jalz.2015.12.009

Ly, M., Adluru, N., Destiche, D.J., Lu, S.Y., Oh, J.M., Hoscheidt, S.M., Alexander, A.L., Okonkwo, O.C., Rowley, H.A., Sager, M.A., Johnson, S.C., & Bendlin, B.B. (2016). Fornix microstructure and memory performance is associated with altered neural connectivity during episodic recognition. Journal of the International Neuropsychological Society, 22(2), 191-204.
View publication via DOI: DOI:10.1017/S1355617715001216

Melah, K. E., Lu, S. Y., Hoscheidt, S. M., Alexander, A. L., Adluru, N., Destiche, D. J., ... Okonkwo, O. C., ... Sager, M. A., Asthana, S., Johnson, S. C., & Bendlin, B. B. (2016). Cerebrospinal fluid markers of Alzheimer's disease pathology and microglial activation are associated with altered White matter microstructure in asymptomatic adults at risk for Alzheimer's disease. Journal of Alzheimer's Disease, 50(3), 873-886.
View publication via DOI: DOI:10.3233/jad-150897

Hoscheidt, S. M., Kellawan, J. M., Berman, S. E., Rivera-Rivera L., A., Krause, R. A. Oh, J. M., . . . Asthana, S., Johnson, S. C., Schrage, W. G., & Bendlin, B. B. (2016). Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults. Journal of Cerebral Blood Flow and Metabolism. Advance online publication.
View publication via DOI: DOI:10.1177/0271678X16663214

Dean, D. C., 3rd, Sojkova, J., Hurley, S., Kecskemeti, S., Okonkwo, O., Bendlin, B. B., Theisen, F., Johnson, S. C., Alexander, A. L., & Gallagher, C. L. (2016). Alterations of myelin content in Parkinson's disease: A cross-sectional neuroimaging study. PLoS One, 11(10), e0163774.
View publication via DOI: DOI:10.1371/journal.pone.0163774

Merluzzi, A. P., Dean, D. C., 3rd, Adluru, N., Suryawanshi, G. S., Okonkwo, O. C., Oh, J. M., Hermann, B. P., Sager, M. A., Asthana, S., Zhang, H., Johnson, S. C., Alexander, A. L., & Bendlin, B. B. (2016). Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging. Neurobiology of Aging, 43, 79-88.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2016.03.026

Racine, A. M., Koscik, R. L., Berman, S. E., Nicholas, C. R., Clark, L. R., Okonkwo, O. C., Rowley, H. A., Asthana, S., Bendlin, B. B., ... & Johnson, S. C. (2016). Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife. Brain, 139(Pt 8), 2261-2274.
View publication via DOI: DOI:10.1093/brain/aww142

Livny, A., Ravona-Springer, R., Heymann, A., Priess, R., Kushnir, T., Tsarfaty, G., ... Johnson, S. C., Bendlin, B. B., & Schnaider Beeri, M. (2016). Long-term variability in glycemic control is associated with White matter hyperintensities in apoe4 genotype carriers with type 2 diabetes. Diabetes Care, 39(6), 1056-1059.
View publication via DOI: DOI:10.2337/dc15-2331

Clark, L. R., Koscik, R. L., Nicholas, C. R., Okonkwo, O. C., Engelman, C. D., Bratzke, L. C., ... Bendlin, B. B., Carlsson, C. M., Asthana, S., Sager, M. A., ... Johnson, S. C. (2016). Mild cognitive impairment in late middle age in the Wisconsin registry for Alzheimer's prevention study: Prevalence and characteristics using robust and standard neuropsychological normative data. Archives of Clinical Neuropsychology. Advance online publication.
View publication via DOI: DOI:10.1093/arclin/acw024

Hoscheidt, S. M., Starks, E. J., Oh, J. M., Zetterberg, H., Blennow, K., Krause, R. A., ... Puglielli, L., Atwood, C. S., ... Asthana, S., Johnson, S. C., & Bendlin, B. B. (2016). Insulin resistance is associated with increased levels of cerebrospinal fluid biomarkers of Alzheimer's disease and reduced memory function in at-risk healthy middle-aged adults. Journal of Alzheimer's Disease, 52(4), 1373-1383.
View publication via DOI: DOI:10.3233/jad-160110

Dougherty, R. J., Ellingson, L. D., Schultz, S. A., Boots, E. A., Meyer, J. D., Lindheimer, J. B., ... Edwards, D. F., ... Bendlin, B. B., Asthana, S., ... Sager, M. A., Johnson, S. C., Okonkwo, O. C., & Cook, D. B. (2016). Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease. Alzheimer's & Dementia, 4, 14-17.
View publication via DOI: DOI:10.1016/j.dadm.2016.03.005

Racine, A. M., Koscik, R. L., Nicholas, C. R., Clark, L. R., Okonkwo, O. C., Oh, J. M., ... Asthana, S., Bendlin, B. B., Blennow, K., Zetterberg, H., Carlsson, C. M., Christian, B. T., & Johnson, S. C. (2016). Cerebrospinal fluid ratios with abeta42 predict preclinical brain beta-amyloid accumulation. Alzheimer's & Dementia, 2, 27-38.
View publication via DOI: DOI:10.1016/j.dadm.2015.11.006

Willette, A. A., & Bendlin, B. B. (2016). Confounders regarding the association of insulin resistance and Alzheimer disease--reply. JAMA Neurology, 73(2), 240-241.
View publication via DOI: DOI:10.1001/jamaneurol.2015.3986

Nicholas, C.P., Okonkwo, O.C., Bendlin, B.B., Oh, J.M., Asthana, S., Rowley, H.A., Hermann, B., Sager, M.A., Johnson, S.C. (2015). Posteromedial hyperactivation during episodic recognition among people with memory decline: Findings from the WRAP Study. Brain Imaging and Behavior, 9(4), 690-702.
View publication via DOI: DOI:10.1007/s11682-014-9322-z

Doherty, D.M., Schultz, S.A., Oh, J.M., Koscik, R.L., Dowling, N.M., Barnhart, T.E., Murali, D., Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Rowley, H.A., Asthana, A., Sager, M.A., Christian, B.T., Johnson, S.C., & Okonkwo, O (2015). Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(2), 160-169.
View publication via DOI: DOI:10.1016/j.dadm.2015.01.003

Almeida, R.P., Schultz, S.A., Austin, B.P., Boots, E.A., Dowling, N.M., Gleason, C.E., Bendlin, B.B., Sager, M.A., Hermann, B.P., Zetterberg, H., Carlsson, C.M., Johnson, S.C., Asthana, S., & Okonkwo, O.C. (2015). Effect of cognitive reserve on age-related changes in cerebrospinal fluid biomarkers of Alzheimer Disease. JAMA Neurology, 72(6), 699-706.
View publication via DOI: DOI:10.1001/jamaneurol.2015.0098

Schultz, S.A., Oh, J.M., Koscik, R.L., Dowling, N.M., Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Rowley, H.A., Asthana, S., Sager, M.A., Johnson, S.C., & Okonkwo, O.C (2015). Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle-aged adults at risk for AD. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(1), 33-40.
View publication via DOI: DOI:10.1016/j.jalz.2014.05.083

La, C., Mossahebi, P., Nair, V.A., Bendlin, B.B., Birn, R., Meyerand, M.E., & Prabhakaran, V. (2015). Age-related changes in inter-network connectivity by component analysis. Frontiers in Aging Neuroscience, 7, 237.
View publication via DOI: DOI:10.3389/fnagi.2015.00237

Schultz, S.A., Boots, E.A., Dougherty, R.J., Almeida, R.P., Oh, J.M., Einerson, K., Korcarz, C.E., Edwards, D., Koscik, R.L., Dowling, N.M., Gallagher, C.L., Bendlin, B.B., Christian, B.T., Zetterberg, H., Blennow, K., Carlsson, C.M., Asthana, S., Hermann (2015). Cardiorespiratory fitness attenuates the influence of amyloid on cognition. Journal of the International Neuropsychological Society, 21(10), 841-850.
View publication via DOI: DOI:10.1017/S1355617715000843

Berman, S.E., Rivera, L.A., Clark, L.R., Racine, A.M., Carlsson, C.M., Bendlin, B.B., Bratzke, L.C., Rowley, H., Turski, P., Zetterberg, H., Blennow, K., Asthana, S., Johnson, S.C., & Wieben, O. (2015). Intracranial arterial 4D-Flow is associated with metrics of brain health and Alzheimer's disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 1(4), 420-428.
View publication via DOI: DOI:10.1016/j.dadm.2015.09.005

Willette, A.A., Bendlin, B.B., Starks, E.J., Birdsill, A.C., Johnson, S.C., Christian, B., Okonkwo, O.C., LaRue, A., Hermann, B., Koscik, R., Jonaitis, E., Sager, M.A., & Asthana, S. (2015). Insulin resistance is associated with lower cerebral glucose uptake in middle-aged adults. JAMA Neurology, 72(9), 1013-1020.
View publication via DOI: DOI:10.1001/jamaneurol.2015.0613

Starks, E.J., O'Grady, P., Hoscheidt, S.M., Racine, A.M., Carlsson, C.M., Zetterberg, H., ... Okonkwo, O.C., Puglielli, L., Asthana, S., ... Anderson, R., ... Sager, M.A., Johnson, S.C., Bendlin, B.B. (2015). Insulin resistance is associated with higher cerebrospinal fluid tau levels in asymptomatic APOE Ε4 carriers. Journal of Alzheimer's Disease, 46(2), 525-33.
View publication via DOI: DOI:10.3233/JAD-150072

Sprecher, K.E., Bendlin, B.B., Racine, A.M., Okonkwo, O.C., Christian, B.T., Koscik, R., Sager, M.A., Asthana, S., Johnson, S.C., & Benca, R.M. (2015). Amyloid Imaging Is Associated With Self-Reported Sleep In Cognitively Healthy Late Middle-Aged Adults. Neurobiology of Aging, 36(9), 2568-76.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2015.05.004

Kim, W.H., Adluru, N., Chung, M.K., Okonkwo, O.C., Johnson, S.C., Bendlin, B.B., & Singh, V. (2015). Multi-resolution statistical analysis of brain connectivity graphs in preclinical Alzheimer's disease. Neuroimage, 118, 103-17.
View publication via DOI: DOI:10.1016/j.neuroimage.2015.05.050

Schultz, S.A., Larson, J., Oh, J., Koscik, R., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Hermann, B.P., Johnson, S.C., Sager, M., LaRue, A., & Okonkwo, O.C. (2015). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease. Brain Imaging & Behavior, 9(4), 729-36.
View publication via DOI: DOI:10.1007/s11682-014-9329-5

Boots, E.A., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., ... Johnson, S.C., & Okonkwo, O.C. (2015). Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease. Brain Imaging & Behavior, 9(3), 639-49.
View publication via DOI: DOI:10.1007/s11682-014-9325-9

Boots, E.A., Schultz, S.A., Almeida, R.P., Oh, J.M., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Sager, M.A., Hermann, B.P., Johnson, S.C., & Okonkwo, O.C. (2015). Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease. Archives of Clinical Neuropsychology, 30(7), 634-42.
View publication via DOI: DOI:10.1093/arclin/acv041

Willette, A. A., Bendlin, B. B., Starks, E. J., Birdsill, A. C., Johnson, S. C., Christian, B. T., Okonkwo, O. C ... Sager, M. A., & Asthana, S. (2015). Association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for Alzheimer disease. JAMA Neurology, 72(9), 1013-1020.
View publication via DOI: DOI:10.1001/jamaneurol.2015.0613

Doherty, B. M., Schultz, S. A., Oh, J. M., Koscik, R. L., Dowling, N. M., Barnhart, T. E., ... Bendlin, B. B., Asthana, S., Sager, M. A., ... Johnson, S. C., & Okonkwo, O. C. (2015). Amyloid burden, cortical thickness, and cognitive function in the Wisconsin registry for Alzheimer's prevention. Alzheimer's & Dementia, 1(2), 160-169.
View publication via DOI: DOI:10.1016/j.dadm.2015.01.003

Koscik, R. L., La, R. A., Jonaitis, E. M., Okonkwo, O. C., Johnson, S. C., Bendlin, B. B., Hermann, B. P., & Sager, M.A. (2014). Emergence of mild cognitive impairment in late-middle-aged adults in the Wisconsin Registry for Alzheimer's Prevention. Dementia and Geriatric Cognitive Disorders, 38(1-2), 16-30.
View publication via DOI: DOI:10.1159/000355682

Johnson, S. C., Christian, B. T., Okonkwo, O. C., Oh, J. M., Harding, S., Xu, G., . . . Bendlin, B. B., . . . Asthana, S., & Sager, M. A. (2014). Amyloid burden and neural function in people at risk for Alzheimer's disease. Neurobiology of Aging, 35(3), 576-584.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2013.09.028

Birdsill, A. C., Koscik, R. L., Jonaitis, E. M., Johnson, S. C., Okonkwo, O. C., Hermann, B. P., . . . Sager, M. A., & Bendlin, B. B. (2014). Regional white matter hyperintensities: Aging, Alzheimer's disease risk, and cognitive function. Neurobiology of Aging, 35(4), 769-776.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2013.10.072

Ly, M., Canu, E., Xu, G., Oh, J., McLaren, D. G., Dowling, N. M., ... Sager, M. A., Johnson, S. C., & Bendlin, B. B. (2014). Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults. Human Brain Mapping, 35(5), 2044-2054.
View publication via DOI: DOI:10.1002/hbm.22311

Okonkwo, O.C., Oh, J.M., Koscik, R., Jonaitis, E., Cleary, C.A., Dowling, N.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Barnhart, T.E., Murali, D., Rowley, H.A., Carlsson, C.M., Gallagher, C.L., Asthana, S., Sager, M.A., Christian, B.T., & Johnson, S.C. (2014). Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. Journal of the International Neuropsychological Society, 20(4), 422-433.
View publication via DOI: DOI:10.1017/S1355617714000113

Racine, A.M., Adluru, N., Alexander, A.L., Christian, B.T., Okonkwo, O.C., Oh, J., Cleary, C.A., Birdsill, A., Hillmer, A.T., Murali, D., Barnhart, T.E., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Dowling, N.M., Asthana, S., Sager, M.A., Bendlin, B.B. (2014). Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation. NeuroImage: Clinical, 4, 604-614.
View publication via DOI: DOI:10.1016/j.nicl.2014.02.001

Li, C., Palotti, M., Holden, J.E., Oh, J., Okonkwo, O., Christian, B.T., Bendlin, B.B., Buyan-Dent, L., Harding, S.J., Stone, C.K., Dejesus, O.T., Nickles, R.J., & Gallagher, C.L. (2014). A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-Fluoro-L-dopa uptake in Parkinson's disease. Synapse, 68(8), 325-331.
View publication via DOI: DOI:10.1002/syn.21745

Adluru, N., Destiche, D.J., Lu, S., Doran, S.T., Birdsill, A.C., Melah, K.E., Okonkwo, O.C., Alexander, A.L., Dowling, N.M., Johnson, S.C., Sager, M.A., & Bendlin, B.B. (2014). White matter microstructure in late middle-age: Effects of Apolipoprotein E4 and parental family history of Alzheimer's disease. NeuroImage: Clinical, 4, 730-742.
View publication via DOI: DOI:10.1016/j.nicl.2014.04.008

Okonkwo, O.C., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R., Gallagher, C.L., Dowling, N.M., Carlsson, C.M., Bendlin, B.B., LaRue, A., Rowley, H.A., Christian, B.T., Asthana, S., Hermann, B.P., Johnson, S.C., & Sager, M.A. (2014). Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology, 83(19), 1753-1760.
View publication via DOI: DOI:10.1212/WNL.0000000000000964

Boots, E.A., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., LaRue, A., Asthana, S., Hermann, B.P., Sager, M.A., Johnson, S.C., & Okonkwo, O.C. (2014). Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease. Alzheimer's & Dementia, 10(4), p165.
View publication via DOI: DOI:10.1016/j.jalz.2014.04.163

Schultz, S.A., Larson, J., Oh, J., Koscik, R., Dowling, N.M., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Hermann, B.P., Johnson, S.C., Sager, M., LaRue, A., & Okonkwo, O.C. (2014). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease. Brain Imaging and Behavior, 9(4), 729-736.
View publication via DOI: DOI:10.1007/s11682-014-9329-5

Peng, Y., Li, M., Clarkson, B.D., Pehar, M., Lao, P.J., Hillmer, A.T., Barnhart, T.E., Christian, B.T., Mitchell, H.A., Bendlin, B.B., Sandor, M., & Puglielli, L. (2014). Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer. Journal of Neuroscience, 34(20), 6772-89.
View publication via DOI: DOI:10.1523/JNEUROSCI.0077-14.2014

Willette, A. A., Johnson, S. C., Birdsill, A. C., Sager, M. A., Christian, B., Baker, L. D., Craft, S., Oh, J., Statz, E., Hermann, B. P., Jonaitis, E. M., Koscik, R. L., La Rue, A., Asthana, S., & Bendlin, B. B. (2014). Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimer's & Dementia, 11(5), 504-510.e1.
View publication via DOI: DOI:10.1016/j.jalz.2014.03.011

Okonkwo, O. C., Oh, J. M., Koscik, R., Jonaitis, E., Cleary, C. A., Dowling, N. M., Bendlin, B. B., LaRue, A., Hermann, B. P., Barnhart, T. E., Murali, D., Rowley, H. A., Carlsson, C. M., Gallagher, C. L., Asthana, S., Sager, M. A., Christian, B. T., & Jo (2014). Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. Journal of the International Neuropsychological Society, 20(04), 422-433.
View publication via DOI: DOI:10.1017/S1355617714000113

Okonkwo, O. C., Xu, G., Oh, J. M., Dowling, N. M., Carlsson, C. M., Gallagher, C. L., Birdsill, A. C., Palotti, M., Wharton, W., Hermann, B. P., LaRue, A., Bendlin, B. B., Rowley, H. A., Asthana, S., Sager, M. A., & Johnson, S. C. (2014). Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease. Cerebral Cortex, 24(4), 978-988.
View publication via DOI: DOI:10.1093/cercor/bhs381

Sridharan, A., Bendlin, B. B., Gallagher, C. L., Oh, J. M., Willette, A. A., Alexander, A. L., Kemnitz, J. W., Colman, R. J., Weindruch, R. H., & Johnson, S. C. (2014). Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: A fiber tractography study. Neuroscience Letters, 569, 38-42.
View publication via DOI: DOI:10.1016/j.neulet.2014.03.047

Birdsill, A. C., Carlsson, C. M., Willette, A. W., Okonkwo, O. C., Johnson, S. C., Xu, G., ... Asthana, S., Sager, M. A., & Bendlin, B. B. (2013). Low cerebral blood flow is associated with lower memory function in metabolic syndrome. Obesity, 21(7), 1313-1320.
View publication via DOI: DOI:10.1002/oby.20170

Sridharan, A., Pehar, M., Salamat, M. S., Pugh, T. D., Bendlin, B. B., Willette, A. A., Anderson, R. M., Kemnitz, J. W., . . . Weindruch, R., Puglielli, L., & Johnson, S. C. (2013). Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: A preliminary quantitative imaging study. Brain Research, 1508, 1-8.
View publication via DOI: DOI:10.1016/j.brainres.2013.02.046

Willette, A. A., Coe, C. L., Birdsill, A. C., Bendlin, B. B., Colman, R. J., Alexander, A. L., ... Weindruch, R. H., & Johnson, S. C. (2013). Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age, 35(6), 2215-2227.
View publication via DOI: DOI:10.1007/s11357-013-9518-y

Gallagher, C., Bell, B., Bendlin, B., Palotti, M., Okonkwo, O., Sodhi, A., ... Johnson, S., ... Alexander, A. (2013). White matter microstructural integrity and executive function in Parkinson's disease. Journal of the International Neuropsychological Society, 19(3), 349-354.
View publication via DOI: DOI:10.1017/s1355617712001373

Willette, A. A., Xu, G., Johnson, S. C., Birdsill, A. C., Jonaitis, E. M., Sager, M. A., ... Asthana, S., & Bendlin, B. B (2013). Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes Care, 36(2), 443-449.
View publication via DOI: DOI:10.2337/dc12-0922

Ries, M.L., McLaren, D.G., Bendlin, B.B., Xu, G., Rowley, H.A., Birn, R., Kastman, E.K., Sager, M.A., Asthana, S., & Johnson, S.C. (2012). Medial prefrontal functional connectivity: relation to memory self-appraisal accuracy in older adults with and without memory disorders. Neuropsychologia, 50(5), 603-611.
View publication via DOI: DOI:10.1016/j.neuropsychologia.2011.12.014

Okonkwo, O.C., Xu, G., Dowling, N.M., Bendlin, B.B., La Rue, A., Hermann, . . . Asthana, S., Sager, M.A. & Johnson, S.C. (2012). Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults. Neurology, 78(22), 1769-1776.
View publication via DOI: DOI:10.1212/WNL.0b013e3182583047

Bendlin, B.B., Carlsson, C.M., Johnson, S.C., Zetterberg, H., Blennow, K., Willette, A.A., Okonkwo, O. C., ... Puglielli, L., Asthana, S., & Sager, M.A. (2012). CSF t-tau/A 42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease. Public Library of Science One, 7(6), e37720.
View publication via DOI: DOI:10.1371/journal.pone.0037720

Willette, A.A., Bendlin, B.B., Colman, R.J., Kastman, E.K., Field, A.S., Alexander, A.L., ... Kemnitz, J.W., Weindruch, R.H., & Johnson, S. (2012). Calorie restriction reduces the influence of glucoregulator dysfunction on regional brain volume in aged rhesus monkeys. Diabetes, 61(5), 1036-1042.
View publication via DOI: DOI:10.2337/db11-1187

Willette, A.A., Gallagher, C., Bendlin, B.B., McLaren, D.G., Kastman, E.K., Canu, E., ... Weindruch, R.H., Coe, C.L., & Johnson, S.C. (2012). Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys. Neurobiology of Aging, 33(4), 670-680.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2010.06.003

Willette, A.A., Xu, G., Johnson, S.C., Birdsill, A.C., Jonaitis, E.M., Sager, M.A., ... Asthana, S., & Bendlin, B.B. (2012). Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes Care, 36(2), 443-449.
View publication via DOI: DOI:10.2337/dc12-0922

Sridharan, A., Willette, A. A., Bendlin, B. B., Alexander, A. L., Coe, C. L., Voytko, M. L., Coleman, R. J., Kemnitz, J. W., Weindruch, R. H., & Johnson, S. C. (2012). Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys. Front Aging Neurosci, 4, 31.
View publication via DOI: DOI:10.3389/fnagi.2012.00031

Willette, A. A., Coe, C. L., Colman, R. J., Bendlin, B. B., Kastman, E. K., Field, A. S., ... Weindruch, R. H., & Johnson, S. C. (2012). Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys. Psychoneuroendocrinology, 37(7), 903-916.
View publication via DOI: DOI:10.1016/j.psyneuen.2011.10.006

Farbota, K. D., Bendlin, B. B., Alexander, A. L., Rowley, H. A., Dempsey, R. J., & Johnson, S. C. (2012). Longitudinal diffusion tensor imaging and neuropsychological correlates in traumatic brain injury patients. Frontiers in Human Neuroscience, 6, 160.
View publication via DOI: DOI:10.3389/fnhum.2012.00160

Gallagher, C.L., Oakes, T.R., Johnson, S.C., Chung, M.K., Holden, J.E., Bendlin, B.B., ... Brown, W.D. (2011). Rate of 6-[18f]fluorodopa uptake decline in striatal subregions in Parkinson's disease. Movement Disorders, 26(4), 614-620.
View publication via DOI: DOI:10.1002/mds.23503

Gallagher, C. L., Johnson, S. C., Bendlin, B. B., Chung, M. K., Holden, J. E., Oakes, T. R., ... Brown, W. D. (2011). A longitudinal study of motor performance and striatal [18f]fluorodopa uptake in Parkinson's disease. Brain Imaging and Behavior, 5(3), 203-211.
View publication via DOI: DOI:10.1007/s11682-011-9124-5

Canu, E., McLaren, D.G., Fitzgerald, M.E., Bendlin, B.B., Zoccatelli, G., Alessandrini, F. ... Johnson, S. C., & Frisoni, G. B. (2011). Mapping the structural brain changes in Alzheimer's disease: The independent contribution of two imaging modalities. Journal of Alzheimer's Disease, 26(3), 263-274.
View publication via DOI: DOI:10.3233/jad-2011-0040

Bendlin, B. B., Canu, E., Willette, A., Kastman, E.K., McLaren, D.G., Kosmatka, K.J., ... Coe, C.L., Weindruch, R.H., Alexander, A.L., & Johnson, S. C. (2011). Effects of aging and calorie restriction on white matter in rhesus macaques. Neurobiology of Aging, 32(12), 2319.e1-2319.e11.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2010.04.008

Walther, K., Bendlin, B. B., Glisky, E. L., Trouard, T. P., Lisse, J. R., Posever, J. O., & Ryan, L. (2011). Anti-inflammatory drugs reduce age-related decreases in brain volume in cognitively normal older adults. Neurobiology of Aging, 32(3), 497-505.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2009.03.006

Ryan, L., Walther, K., Bendlin, B. B., Lue, L. F., Walker, D. G., & Glisky, E. L. (2011). Age-related differences in white matter integrity and cognitive function are related to APOE status. Neuroimage, 54(2), 1565-1577 .
View publication via DOI: DOI:10.1016/j.neuroimage.2010.08.052

Bendlin, B.B., Fitzgerald, M.E., Ries, M.L., Xu, G., Kastman, E.K., Thiel, B.W., Rowley, H.A., Lazar, M., Alexander, A.L., & Johnson, S.C. (2010). White matter in aging and cognition: A cross-sectional study of microstructure in adults aged eighteen to eighty-three. Developmental Neuropsychology, 35(3), 257-277.
View publication via DOI: DOI:10.1080/87565641003696775

Bendlin, B.B., Carlsson, C.M., Gleason, C.E., Johnson, S.C., Sodhi, A., Gallagher, C.L., Puglielli, L., Engelman, C.D., Ries, M.L., Xu, G., Wharton, W., & Asthana, S. (2010). Midlife predictors of Alzheimer's disease. Maturitas, 65(2), 131-137.
View publication via DOI: DOI:10.1016/j.maturitas.2009.12.014

Bendlin, B.B., Newman, L.M., Ries, M.L., Puglielli, L., Carlsson, C.M., Sager, M.A., ... Asthana, S., & Johnson, S.C. (2010). NSAIDs may protect against age-related brain atrophy. Frontiers in Aging Neuroscience, 2(35).
View publication via DOI: DOI:10.3389/fnagi.2010.00035

Bendlin, B.B., Ries, M.L., Canu, E., Sodhi, A., Lazar, M., Alexander, A.L., Carlsson, C.M., Sager, M.A. Asthana, S., & Johnson, S. C. (2010). White matter is altered with parental family history of Alzheimer's disease. Alzheimer's & Dementia, 6(5), 394-403.
View publication via DOI: DOI:10.1016/j.jalz.2009.11.003

Ward, M. A., Bendlin, B. B., McLaren, D. G., Hess, T. M., Gallagher, C. L., Kastman, E. K., ... Asthana, S., .. Sager, M.A., & Johnson, S. C. (2010). Low HDL cholesterol is associated with lower gray matter volume in cognitively healthy adults. Frontiers in Aging Neuroscience, 2(29).
View publication via DOI: DOI:10.3389/fnagi.2010.00029

Willette, A.A., Bendlin, B.B., McLaren, D.G., Canu, E., Kastman, E.K., Kosmatka, K.J., ... Weindruch, R.H., Coe, C.L., & Johnson, S.C. (2010). Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys. NeuroImage, 51(3), 987-994.
View publication via DOI: DOI:10.1016/j.neuroimage.2010.03.015

Kastman, E.K., Willette, A.A., Coe, C.L., Bendlin, B.B., Kosmatka, K.J., McLaren, D.G., ... Weindruch, R.H., & Johnson, S. C. (2010). A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. The Journal of Neuroscience, 32(34), 11897-11904.
View publication via DOI: DOI:10.1523/JNEUROSCI.2553-12.2012

McLaren, D.G., Kosmatka, K.J., Kastman, E.K., Bendlin, B.B., & Johnson, S.C. (2010). Rhesus macaque brain morphometry: A methodological comparison of voxel-wise approaches. Methods, 50(3), 157-165.
View publication via DOI: DOI:10.1016/j.ymeth.2009.10.003

Canu, E., McLaren, D. G., Fitzgerald, M. E., Bendlin, B. B., Zoccatelli, G., Alessandrini, F., ... Johnson, S. C., & Frisoni, G. B. (2010). Microstructural diffusion changes are independent of macrostructural volume loss in moderate to severe Alzheimer's disease. Journal of Alzheimer's Disease, 19(3), 963-976.
View publication via DOI: DOI:10.3233/jad-2010-1295

Xu, G., McLaren, D.G., Ries, M.L., Fitzgerald, M.E., Bendlin, B.B., Rowley, H.A., Sager, M.A., Atwood, C.S., Asthana, S., & Johnson, S.C. (2009). The influence of parental history of Alzheimer's disease and apolipoprotein E 4 on the BOLD signal during recognition memory. Brain, 132, 383-391.
View publication via DOI: DOI:10.1093/brain/awn254

Bendlin, B.B., Ries, M.L., Lazar, M., Alexander, A.L., Dempsey, R.J., Rowley, H.A., Sherman, J.E., & Johnson, S.C. (2008). Longitudinal changes in patients with traumatic brain injury assessed with diffusion tensor and volumetric imaging. Neuroimage, 42, 503-51.
View publication via DOI: DOI:10.1016/j.neuroimage.2008.04.254

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