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AGING NEWS:

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Biology of Aging
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Ozioma Okonkwo

Ozioma C. Okonkwo

PhD, University of Alabama at Birmingham
Assistant Professor, Department of Medicine- Geriatrics
ozioma@medicine.wisc.edu
http://www.medicine.wisc.edu/people-search/people/staff/1105/Okonkwo_Ozioma/
www.brainmap.wisc.edu/people/56-OC-Okonkwo ntp.neuroscience.wisc.edu/okonkwo.htm


Brain and Biomarker Changes in Preclinical Alzheimer's Disease

Dr. Okonkwo's research focuses on clarifying how alterations in the brain and other biomolecules (such as cerebrospinal fluid β-amyloid) place some cognitively-normal individuals on a pernicious trajectory that culminates in probable Alzheimer's disease. In this context, Dr. Okonkwo is also interested in discovering new knowledge concerning the modulation of the link between brain changes and cognitive decline by both modifiable (e.g., cognitively-stimulating activities, physical exercise) and non-modifiable (e.g., genetic vulnerability) factors.



Representative Publications
Law, L. L., Schultz, S. A., Boots, E. A., Einerson, J. A., Dougherty, R. J., Oh, J. M., Korcarz, C. E., Edwards, D. F., ... Bendlin, B. B., Carlsson, C. M., Asthana, S., Hermann, B. P., Sager, M. A., Johnson, S. C., ... & Okonkwo, O. C. (2017). Chronotropic response and cognitive function in a cohort at risk for Alzheimer's disease. Journal of Alzheimer's Disease, 56(1), 351-359.
View publication via DOI: DOI:10.3233/jad-160642

Dougherty, R. J., Schultz, S. A., Boots, E. A., Ellingson, L. D., Meyer, J. D., Van Riper, S., Stegner, A. J., Edwards, D. F., ... Bendlin, B. B., Asthana, S., ... Sager, M. A., ... Johnson, S. C., Okonkwo, O. C., & Cook, D. B. (2017). Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease. Brain and Behavior. Advance online publication.
View publication via DOI: DOI:10.1002/brb3.625

Okonkwo, O. C., & Asthana, S. (2017). Dementia trends in the United States: Read up and weigh in. JAMA Internal Medicine, 177(1), 58-60.
View publication via DOI: DOI:10.1001/jamainternmed.2016.7073

Darst, B. F., Koscik, R. L., Racine, A. M., Oh, J. M., Krause, R. A., Carlsson, C. M., ... Bendlin, B. B., Okonkwo, O. C., ... Sager, M. A., Asthana, S., Johnson, S. C., & Engelman, C. D. (2017). Pathway-specific polygenic risk scores as predictors of amyloid-beta deposition and cognitive function in a sample at increased risk for Alzheimer's disease. Journal of Alzheimer's Disease, 55(2), 473-484.
View publication via DOI: DOI:10.3233/jad-160195

Okonkwo, O. C., & Vemuri, P. (2017). Stemming the Alzheimer tsunami: Introduction to the special issue on reserve and resilience in Alzheimer's disease. Brain Imaging and Behavior. Advance online publication.
View publication via DOI: DOI:10.1007/s11682-017-9677-z

Clark, L. R., Racine, A. M., Koscik, R. L., Okonkwo, O. C., Engelman, C. D., Carlsson, C. M., Asthana, S., Bendlin, B. B., ... Sager, M. A., Christian, B. T., & Johnson, S. C. (2016). Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin registry for Alzheimer's prevention study. Alzheimer's & Dementia, 12(7), 805-814.
View publication via DOI: DOI:10.1016/j.jalz.2015.12.009

Ly, M., Adluru, N., Destiche, D.J., Lu, S.Y., Oh, J.M., Hoscheidt, S.M., Alexander, A.L., Okonkwo, O.C., Rowley, H.A., Sager, M.A., Johnson, S.C., & Bendlin, B.B. (2016). Fornix microstructure and memory performance is associated with altered neural connectivity during episodic recognition. Journal of the International Neuropsychological Society, 22(2), 191-204.
View publication via DOI: DOI:10.1017/S1355617715001216

Melah, K. E., Lu, S. Y., Hoscheidt, S. M., Alexander, A. L., Adluru, N., Destiche, D. J., ... Okonkwo, O. C., ... Sager, M. A., Asthana, S., Johnson, S. C., & Bendlin, B. B. (2016). Cerebrospinal fluid markers of Alzheimer's disease pathology and microglial activation are associated with altered White matter microstructure in asymptomatic adults at risk for Alzheimer's disease. Journal of Alzheimer's Disease, 50(3), 873-886.
View publication via DOI: DOI:10.3233/jad-150897

Koscik, R. L., Berman, S. E., Clark, L. R., Mueller, K. D., Okonkwo, O. C., Gleason, C. E., Hermann, B. P., Sager, M. A., & Johnson, S. C. (2016). Intraindividual cognitive variability in middle age predicts cognitive impairment 8-10 years later: Results from the Wisconsin registry for Alzheimer's prevention. Journal of the International Neuropsychological Society, 22(10), 1016-1025.
View publication via DOI: DOI:10.1017/s1355617716

Dean, D. C., 3rd, Sojkova, J., Hurley, S., Kecskemeti, S., Okonkwo, O., Bendlin, B. B., Theisen, F., Johnson, S. C., Alexander, A. L., & Gallagher, C. L. (2016). Alterations of myelin content in Parkinson's disease: A cross-sectional neuroimaging study. PLoS One, 11(10), e0163774.
View publication via DOI: DOI:10.1371/journal.pone.0163774

Merluzzi, A. P., Dean, D. C., 3rd, Adluru, N., Suryawanshi, G. S., Okonkwo, O. C., Oh, J. M., Hermann, B. P., Sager, M. A., Asthana, S., Zhang, H., Johnson, S. C., Alexander, A. L., & Bendlin, B. B. (2016). Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging. Neurobiology of Aging, 43, 79-88.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2016.03.026

Racine, A. M., Koscik, R. L., Berman, S. E., Nicholas, C. R., Clark, L. R., Okonkwo, O. C., Rowley, H. A., Asthana, S., Bendlin, B. B., ... & Johnson, S. C. (2016). Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife. Brain, 139(Pt 8), 2261-2274.
View publication via DOI: DOI:10.1093/brain/aww142

Clark, L. R., Koscik, R. L., Nicholas, C. R., Okonkwo, O. C., Engelman, C. D., Bratzke, L. C., ... Bendlin, B. B., Carlsson, C. M., Asthana, S., Sager, M. A., ... Johnson, S. C. (2016). Mild cognitive impairment in late middle age in the Wisconsin registry for Alzheimer's prevention study: Prevalence and characteristics using robust and standard neuropsychological normative data. Archives of Clinical Neuropsychology. Advance online publication.
View publication via DOI: DOI:10.1093/arclin/acw024

Dougherty, R. J., Ellingson, L. D., Schultz, S. A., Boots, E. A., Meyer, J. D., Lindheimer, J. B., ... Edwards, D. F., ... Bendlin, B. B., Asthana, S., ... Sager, M. A., Johnson, S. C., Okonkwo, O. C., & Cook, D. B. (2016). Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease. Alzheimer's & Dementia, 4, 14-17.
View publication via DOI: DOI:10.1016/j.dadm.2016.03.005

Racine, A. M., Koscik, R. L., Nicholas, C. R., Clark, L. R., Okonkwo, O. C., Oh, J. M., ... Asthana, S., Bendlin, B. B., Blennow, K., Zetterberg, H., Carlsson, C. M., Christian, B. T., & Johnson, S. C. (2016). Cerebrospinal fluid ratios with abeta42 predict preclinical brain beta-amyloid accumulation. Alzheimer's & Dementia, 2, 27-38.
View publication via DOI: DOI:10.1016/j.dadm.2015.11.006

Nicholas, C.P., Okonkwo, O.C., Bendlin, B.B., Oh, J.M., Asthana, S., Rowley, H.A., Hermann, B., Sager, M.A., Johnson, S.C. (2015). Posteromedial hyperactivation during episodic recognition among people with memory decline: Findings from the WRAP Study. Brain Imaging and Behavior, 9(4), 690-702.
View publication via DOI: DOI:10.1007/s11682-014-9322-z

Doherty, D.M., Schultz, S.A., Oh, J.M., Koscik, R.L., Dowling, N.M., Barnhart, T.E., Murali, D., Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Rowley, H.A., Asthana, A., Sager, M.A., Christian, B.T., Johnson, S.C., & Okonkwo, O (2015). Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(2), 160-169.
View publication via DOI: DOI:10.1016/j.dadm.2015.01.003

Almeida, R.P., Schultz, S.A., Austin, B.P., Boots, E.A., Dowling, N.M., Gleason, C.E., Bendlin, B.B., Sager, M.A., Hermann, B.P., Zetterberg, H., Carlsson, C.M., Johnson, S.C., Asthana, S., & Okonkwo, O.C. (2015). Effect of cognitive reserve on age-related changes in cerebrospinal fluid biomarkers of Alzheimer Disease. JAMA Neurology, 72(6), 699-706.
View publication via DOI: DOI:10.1001/jamaneurol.2015.0098

Schultz, S.A., Oh, J.M., Koscik, R.L., Dowling, N.M., Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Rowley, H.A., Asthana, S., Sager, M.A., Johnson, S.C., & Okonkwo, O.C (2015). Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle-aged adults at risk for AD. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(1), 33-40.
View publication via DOI: DOI:10.1016/j.jalz.2014.05.083

Willette, A.A., Bendlin, B.B., Starks, E.J., Birdsill, A.C., Johnson, S.C., Christian, B., Okonkwo, O.C., LaRue, A., Hermann, B., Koscik, R., Jonaitis, E., Sager, M.A., & Asthana, S. (2015). Insulin resistance is associated with lower cerebral glucose uptake in middle-aged adults. JAMA Neurology, 72(9), 1013-1020.
View publication via DOI: DOI:10.1001/jamaneurol.2015.0613

Starks, E.J., O'Grady, P., Hoscheidt, S.M., Racine, A.M., Carlsson, C.M., Zetterberg, H., ... Okonkwo, O.C., Puglielli, L., Asthana, S., ... Anderson, R., ... Sager, M.A., Johnson, S.C., Bendlin, B.B. (2015). Insulin resistance is associated with higher cerebrospinal fluid tau levels in asymptomatic APOE Ε4 carriers. Journal of Alzheimer's Disease, 46(2), 525-33.
View publication via DOI: DOI:10.3233/JAD-150072

Sprecher, K.E., Bendlin, B.B., Racine, A.M., Okonkwo, O.C., Christian, B.T., Koscik, R., Sager, M.A., Asthana, S., Johnson, S.C., & Benca, R.M. (2015). Amyloid Imaging Is Associated With Self-Reported Sleep In Cognitively Healthy Late Middle-Aged Adults. Neurobiology of Aging, 36(9), 2568-76.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2015.05.004

Kim, W.H., Adluru, N., Chung, M.K., Okonkwo, O.C., Johnson, S.C., Bendlin, B.B., & Singh, V. (2015). Multi-resolution statistical analysis of brain connectivity graphs in preclinical Alzheimer's disease. Neuroimage, 118, 103-17.
View publication via DOI: DOI:10.1016/j.neuroimage.2015.05.050

Schultz, S.A., Larson, J., Oh, J., Koscik, R., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Hermann, B.P., Johnson, S.C., Sager, M., LaRue, A., & Okonkwo, O.C. (2015). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease. Brain Imaging & Behavior, 9(4), 729-36.
View publication via DOI: DOI:10.1007/s11682-014-9329-5

Boots, E.A., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., ... Johnson, S.C., & Okonkwo, O.C. (2015). Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease. Brain Imaging & Behavior, 9(3), 639-49.
View publication via DOI: DOI:10.1007/s11682-014-9325-9

Boots, E.A., Schultz, S.A., Almeida, R.P., Oh, J.M., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Sager, M.A., Hermann, B.P., Johnson, S.C., & Okonkwo, O.C. (2015). Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease. Archives of Clinical Neuropsychology, 30(7), 634-42.
View publication via DOI: DOI:10.1093/arclin/acv041

Willette, A. A., Bendlin, B. B., Starks, E. J., Birdsill, A. C., Johnson, S. C., Christian, B. T., Okonkwo, O. C ... Sager, M. A., & Asthana, S. (2015). Association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for Alzheimer disease. JAMA Neurology, 72(9), 1013-1020.
View publication via DOI: DOI:10.1001/jamaneurol.2015.0613

Doherty, B. M., Schultz, S. A., Oh, J. M., Koscik, R. L., Dowling, N. M., Barnhart, T. E., ... Bendlin, B. B., Asthana, S., Sager, M. A., ... Johnson, S. C., & Okonkwo, O. C. (2015). Amyloid burden, cortical thickness, and cognitive function in the Wisconsin registry for Alzheimer's prevention. Alzheimer's & Dementia, 1(2), 160-169.
View publication via DOI: DOI:10.1016/j.dadm.2015.01.003

Koscik, R. L., La, R. A., Jonaitis, E. M., Okonkwo, O. C., Johnson, S. C., Bendlin, B. B., Hermann, B. P., & Sager, M.A. (2014). Emergence of mild cognitive impairment in late-middle-aged adults in the Wisconsin Registry for Alzheimer's Prevention. Dementia and Geriatric Cognitive Disorders, 38(1-2), 16-30.
View publication via DOI: DOI:10.1159/000355682

Johnson, S. C., Christian, B. T., Okonkwo, O. C., Oh, J. M., Harding, S., Xu, G., . . . Bendlin, B. B., . . . Asthana, S., & Sager, M. A. (2014). Amyloid burden and neural function in people at risk for Alzheimer's disease. Neurobiology of Aging, 35(3), 576-584.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2013.09.028

Birdsill, A. C., Koscik, R. L., Jonaitis, E. M., Johnson, S. C., Okonkwo, O. C., Hermann, B. P., . . . Sager, M. A., & Bendlin, B. B. (2014). Regional white matter hyperintensities: Aging, Alzheimer's disease risk, and cognitive function. Neurobiology of Aging, 35(4), 769-776.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2013.10.072

Okonkwo, O.C., Oh, J.M., Koscik, R., Jonaitis, E., Cleary, C.A., Dowling, N.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Barnhart, T.E., Murali, D., Rowley, H.A., Carlsson, C.M., Gallagher, C.L., Asthana, S., Sager, M.A., Christian, B.T., & Johnson, S.C. (2014). Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. Journal of the International Neuropsychological Society, 20(4), 422-433.
View publication via DOI: DOI:10.1017/S1355617714000113

Sacktor, N., Nakasujja, N., Redd, A.D., Manucci, J., Laeyendecker, O., Wendel, S.K., Porcella, S.F., Martens, C., Bruno, D., Skolasky, R.L., Okonkwo, O.C., Robertson, K., Musisi, S., Katabira, E., & Quinn, T.C. (2014). HIV subtype is not associated with dementia among individuals with moderate and advanced immunosuppression in Kampala, Uganda. Metabolic Brain Disease, 29(2), 261-268.
View publication via DOI: DOI:10.1007/s11011-014-9498-3

Racine, A.M., Adluru, N., Alexander, A.L., Christian, B.T., Okonkwo, O.C., Oh, J., Cleary, C.A., Birdsill, A., Hillmer, A.T., Murali, D., Barnhart, T.E., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Dowling, N.M., Asthana, S., Sager, M.A., Bendlin, B.B. (2014). Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation. NeuroImage: Clinical, 4, 604-614.
View publication via DOI: DOI:10.1016/j.nicl.2014.02.001

Kim, W.H., Singh, V., Chung, M.K., Hinrichs, C., Pachauri, D., Okonkwo, O.C., & Johnson, S.C. (2014). Multi-resolutional shape features via non-Euclidean wavelets: Applications to statistical analysis of cortical thickness. NeuroImage, 93(Pt 1), 107-123.
View publication via DOI: DOI:10.1016/j.neuroimage.2014.02.028

Li, C., Palotti, M., Holden, J.E., Oh, J., Okonkwo, O., Christian, B.T., Bendlin, B.B., Buyan-Dent, L., Harding, S.J., Stone, C.K., Dejesus, O.T., Nickles, R.J., & Gallagher, C.L. (2014). A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-Fluoro-L-dopa uptake in Parkinson's disease. Synapse, 68(8), 325-331.
View publication via DOI: DOI:10.1002/syn.21745

Adluru, N., Destiche, D.J., Lu, S., Doran, S.T., Birdsill, A.C., Melah, K.E., Okonkwo, O.C., Alexander, A.L., Dowling, N.M., Johnson, S.C., Sager, M.A., & Bendlin, B.B. (2014). White matter microstructure in late middle-age: Effects of Apolipoprotein E4 and parental family history of Alzheimer's disease. NeuroImage: Clinical, 4, 730-742.
View publication via DOI: DOI:10.1016/j.nicl.2014.04.008

Ithapu, V., Singh, V., Okonkwo, O.C., & Johnson, S.C (2014). Randomized denoising autoencoders for smaller and efficient imaging based AD clinical trials. Medical Image Computing and Computer-Assisted Intervention, 17(Pt 2), 470-8.

Okonkwo, O.C. (2014). At the crossroads of preclinical AD and normal brain ageing. Lancet Neurology, 13(10), 965-966.
View publication via DOI: DOI:10.1016/S1474-4422(14)70207-8

Okonkwo, O.C., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R., Gallagher, C.L., Dowling, N.M., Carlsson, C.M., Bendlin, B.B., LaRue, A., Rowley, H.A., Christian, B.T., Asthana, S., Hermann, B.P., Johnson, S.C., & Sager, M.A. (2014). Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology, 83(19), 1753-1760.
View publication via DOI: DOI:10.1212/WNL.0000000000000964

Boots, E.A., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., LaRue, A., Asthana, S., Hermann, B.P., Sager, M.A., Johnson, S.C., & Okonkwo, O.C. (2014). Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease. Alzheimer's & Dementia, 10(4), p165.
View publication via DOI: DOI:10.1016/j.jalz.2014.04.163

Gallagher, C.L., Bell, B., Palotti, M., Oh, J., Christian, B.T., Okonkwo, O., Sojkova, J., Buyan-Dent, L., Nickles, R.J., Harding, S.J., Stone, C.K., Johnson, S.C., & Holden, J.E. (2014). Anterior cingulate dopamine turnover and behavior change in Parkinson's disease. Brain Imaging and Behavior, 9(4), 821-827.
View publication via DOI: DOI:10.1007/s11682-014-9338-4

Schultz, S.A., Larson, J., Oh, J., Koscik, R., Dowling, N.M., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Hermann, B.P., Johnson, S.C., Sager, M., LaRue, A., & Okonkwo, O.C. (2014). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease. Brain Imaging and Behavior, 9(4), 729-736.
View publication via DOI: DOI:10.1007/s11682-014-9329-5

Nowrangi, M.A., Okonkwo, O., Lyketsos, C., Oishi, K., Mori, S., Albert, M., & Mielke, M.M (2014). Atlas-based diffusion tensor imaging correlates of executive function. Journal of Alzheimer's Disease, 44(2), 585-598.
View publication via DOI: DOI:10.3233/JAD-141937

Okonkwo, O. C., Oh, J. M., Koscik, R., Jonaitis, E., Cleary, C. A., Dowling, N. M., Bendlin, B. B., LaRue, A., Hermann, B. P., Barnhart, T. E., Murali, D., Rowley, H. A., Carlsson, C. M., Gallagher, C. L., Asthana, S., Sager, M. A., Christian, B. T., & Jo (2014). Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. Journal of the International Neuropsychological Society, 20(04), 422-433.
View publication via DOI: DOI:10.1017/S1355617714000113

Okonkwo, O. C., Xu, G., Oh, J. M., Dowling, N. M., Carlsson, C. M., Gallagher, C. L., Birdsill, A. C., Palotti, M., Wharton, W., Hermann, B. P., LaRue, A., Bendlin, B. B., Rowley, H. A., Asthana, S., Sager, M. A., & Johnson, S. C. (2014). Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease. Cerebral Cortex, 24(4), 978-988.
View publication via DOI: DOI:10.1093/cercor/bhs381

Birdsill, A. C., Carlsson, C. M., Willette, A. W., Okonkwo, O. C., Johnson, S. C., Xu, G., ... Asthana, S., Sager, M. A., & Bendlin, B. B. (2013). Low cerebral blood flow is associated with lower memory function in metabolic syndrome. Obesity, 21(7), 1313-1320.
View publication via DOI: DOI:10.1002/oby.20170

Stoeckel, L. E., Stewart, C. C., Griffith, H. R., Triebel, K., Okonkwo, O. C., den Hollander, J. A., Martin, R. C., . . . Marson, D.C. (2013). MRI volume of the medial frontal cortex is predictive of financial capacity deficits in patients with mild Alzheimer's disease. Brain Imaging and Behavior, 7(3), 282-292.
View publication via DOI: DOI:10.1007/s11682-013-9226-3

Griffith, H. R., Okonkwo, O. C., Stewart, C. C., Stoeckel, L. E., den Hollander, J. A., Elgin, J. M., . . . Wadley, V. G. (2013). Lower hippocampal volume predicts decrements in lane control among drivers with amnestic MCI. Journal of Geriatric Psychiatry and Neurology, 26(4), 259-66.
View publication via DOI: DOI:10.1177/0891988713509138

Engelman, C. D., Koscik, R. L., Jonaitis, E. M., Okonkwo, O. C., Hermann, B. P., La Rue, A., & Sager, M. A. (2013). Interaction between two cholesterol metabolism genes influences memory: Findings from the Wisconsin registry for Alzheimer's prevention. Journal of Alzheimers Disease, 36(4), 749-757.
View publication via DOI: DOI:10.3233/jad-130482

Gallagher, C., Bell, B., Bendlin, B., Palotti, M., Okonkwo, O., Sodhi, A., ... Johnson, S., ... Alexander, A. (2013). White matter microstructural integrity and executive function in Parkinson's disease. Journal of the International Neuropsychological Society, 19(3), 349-354.
View publication via DOI: DOI:10.1017/s1355617712001373

Okonkwo, O.C., Xu, G., Dowling, N.M., Bendlin, B.B., La Rue, A., Hermann, . . . Asthana, S., Sager, M.A. & Johnson, S.C. (2012). Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults. Neurology, 78(22), 1769-1776.
View publication via DOI: DOI:10.1212/WNL.0b013e3182583047

Bendlin, B.B., Carlsson, C.M., Johnson, S.C., Zetterberg, H., Blennow, K., Willette, A.A., Okonkwo, O. C., ... Puglielli, L., Asthana, S., & Sager, M.A. (2012). CSF t-tau/A 42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease. Public Library of Science One, 7(6), e37720.
View publication via DOI: DOI:10.1371/journal.pone.0037720

Okonkwo, O. C., Xu, G., Oh, J. M., Dowling, N. M., Carlsson, C. M., Gallagher, C., . . . Asthana, S., Sager, M. A., & Johnson, S. C. (2012). Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease. Cerebral Cortex. Advance online publication.
View publication via DOI: DOI:10.1093/cercor/bhs381

Okonkwo, O. C., Mielke, M. M., Griffith, H. R., Moghekar, A. R., O'Brien, R. J., Shaw, L. M., Trojanowski, J. Q., Albert, M. S., & the Alzheimer's Disease Neuroimaging Initiative (2011). Cerebrospinal fluid profiles predict prospective course and outcome among persons with amnestic mild cognitive impairment. Archives of Neurology, 68(1), 113-119.
View publication via DOI: DOI:10.1001/archneurol.2010.334

Okonkwo, O. C., Cohen, R. A., Gunstad, J., & Poppas, A. (2011). Cardiac output, blood pressure variability, and cognitive decline in geriatric cardiac patients. Journal of Cardioplumonary Rehabilitation and Prevention, 31(5), 290-7.
View publication via DOI: DOI:10.1097/HCR.0b013e318220a817

Mielke, M. M., Okonkwo, O. C., Oishi, K., Mori, S., Tighe, S., Miller, M. I., ...Lyketsos, C. G (2011). Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease. Alzheimer's & Dementia, 8(2), 105-13.
View publication via DOI: DOI:10.1016/j.jalz.2011.05.2416

Okonkwo, O. C., Alosco, M. L., Jerskey, B. A., Sweet, L. H., Ott, B. R., Tremont, G., & the Alzheimer's Disease Neuroimaging Initiative. (2010). Cerebral atrophy, apolipoprotein E ε4, and rate of decline in everyday function among patients with amnestic mild cognitive impairment. Alzheimer's & Dementia, 6(5), 404-411.
View publication via DOI: DOI:10.1016/j.jalz.2010.02.003

Okonkwo, O. C., Alosco, M. L., Griffith, H. R., Mielke, M. M., Shaw, L. M., Trojanowski, J. Q., Tremont, G., & the Alzheimer's Disease Neuroimaging Initiative (2010). Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: Normal aging, mild cognitive impairment, and Alzheimer's disease. Archives of Neurology, 67(6), 688-696.
View publication via DOI: DOI:10.1001/archneurol.2010.118

Ott, B. R., Cohen, R. A., Gongvatana, A., Okonkwo, O. C., Johanson, C. E., Stopa, E. G., Donahue, J. E., Silverberg, G. D., & the Alzheimer's Disease Neuroimaging Initiative. (2010). Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's Disease, 20(2), 647-57.
View publication via DOI: DOI:10.3233/JAD-2010-1406

Okonkwo, O. C., Griffith, H. R., Vance, D. E., Marson, D. C., Ball, K., & Wadley, V. G. (2009). Awareness of functional difficulties in mild cognitive impairment: A multi-domain assessment approach. Journal of the American Geriatrics Society, 57(6), 978-984.
View publication via DOI: DOI:10.1111/j.1532-5415.2009.02261.x

Okonkwo, O., Wadley, V. G., Griffith, H. R., Belue, K., Lanza, S., Zamrini, E. Y., ...Marson, D. C. (2008). Awareness of deficits in financial abilities in patients with mild cognitive impairment: Going beyond self-informant discrepancy. American Journal of Geriatric Psychiatry, 16(8), 650-9.
View publication via DOI: DOI:10.1097/JGP.0b013e31817e8a9d

Okonkwo, O. C., Griffith, H. R., Copeland, J. N., Belue, K., Lanza, S., Zamrini, E. Y., ... Marson, D. C. (2008). Medical decision-making capacity in mild cognitive impairment: A three-year longitudinal study. Neurology, 71(19), 1474-80.
View publication via DOI: DOI:10.1212/01.wnl.0000334301.32358.48

Okonkwo, O., Griffith, H. R., Belue, K., Lanza, S., Zamrini, E. Y., Harrell, L. E., ...Marson, D. C. (2007). Medical decision-making capacity in patients with mild cognitive impairment. Neurology, 69(15), 1528-35.
View publication via DOI: DOI:10.1212/01.wnl.0000277639.90611.d9

Okonkwo, O. C., Wadley, V., Griffith, H. R., Ball, K., & Marson, D. C (2006). Cognitive correlates of financial abilities in mild cognitive impairment. Journal of the American Geriatrics Society, 54(11), 1745-1750.
View publication via DOI: DOI:10.1111/j.1532-5415.2006.00916.x

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