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Training Grant-
Biology of Aging

Jill Barnes

Jill N.. Barnes

PhD, University of Texas at Austin
Assistant Professor, Dept. of Kinesiology
Affiliate Faculty, Department of Medicine-Geriatrics

The Effect of Aging on the Structure and Function of the Blood Vessels in Humans

My primary line of research is to understand the effect of aging on the structure and function of the blood vessles in humans and how this relates to the risk of cardiovascular disease and dementia. I am specifically interested in how age-associated changes in the structure and function of blood vessels influence the control of blood flow to the brain.

Focus areas

  • Identifying vascular control mechanisms underlying the age-associated changes in cerebral blood flow regulation. These mechanisms include alterations in prostaglandin signaling cascades, sympathetic nerve activity, and intravascular activation.
  • Understanding how cerebral blood flow regulation differs between men and women and how this varies throughout the lifespan. Specifically, we want to understand how men and women adapt to transient changes in blood flow to the brain.
  • Determine how neurovascular control of blood pressure is affected by aging and changes in sex hormones, particularly focusing on the autonomic control of blood pressure in women.
  • Establish whether neurovascular control of both blood pressure and blood flow are affected by conditions of accelerated aging, and how lifestyle and/or pharmacological interventions alter this neurovascular control.

Relevance to the Institute on Aging
My graduate training focused on understanding cardiovascular aging in humans. During my graduate work I concentrated on mechanisms of vascular aging. During my postdoctoral work, I focused on age-related changes in neurovascular control of blood pressure and cerebral blood flow regulation. My current research investigates potential underlying mechanisms of age-related changes in cerebral blood flow regulation. By identifying potential risk factors, this will set the stage to optimize novel interventions to promote successful aging.

Representative Publications
Barnes, J.N., Harvey, R.E., Miller, K.B., Jayachandran, M., Malterer, K.M., Lahr, B.D., Bailey, K.R., Joyner, M.J., & Miller, V.M. (2018). Cerebrovascular reactivity and vascular activation in postmenopausal women with histories of preeclampsia. Hypertension, 71(1), 110-117.
View publication via DOI: DOI:Hypertension, 71(1), 110-117

Barnes, J.N. (2017). Sex specific factors regulating pressure and flow. Experimental Physiology, 102(11), 1385-1392.
View publication via DOI: DOI:10.1113/EP086531

Harvey, R.E., Johnson, M.C., Ranadive, S.M., Joyner, M.J., Miller, V.M., & Barnes, J.N. (2017). Aortic hemodynamics in postmenopausal women following cessation of menopausal hormone therapy. Physiological Report. Advanced Online Publication, 5(23), e13535.
View publication via DOI: DOI:Physiological Report. Advanced Online Publication, 5(23), e13535

Barnes, J.N., Harvey, R.E., Zuk, S.M., Lundt, E.S., Lesnick, T.G., Gunter, J.L., Senjem, M.L., Shuster, L.T., Miller, V.M., Jack, C.R., Joyner, M.J., & Kantarci, K. (2017). Aortic hemodynamics and white matter hyperintensities in normotensive postmenopausal women. Journal of neurology, 264(5), 938-945.
View publication via DOI: DOI:10.1007/s00415-017-8476-1

Pienado, A., Harvey, R.E., Hart, E.C., Charkoudian, N., Curry, T.B., Nicholson, W.T., Wallin, B.G., Joyner, M.J., & Barnes, J.N. (2017). Neural control of blood pressure in women: differences according to age. Clinical Autonomic Research, 27(3), 157-165.
View publication via DOI: DOI:10.1007/s10286-017-0403-0

Ranadive, S.M., Harvey, R.E., Lahr, B., Miller, V.M., Joyner, M.J. & Barnes, J.N. (2017). Sympathetic responsiveness is not increased in women with a history of hypertensive pregnancy. American Journal of Physiology, 312, R49-54.
View publication via DOI: DOI:10.1152/ajpregu.00379

Hughes, J.M., Charkoudian, N., Barnes, J.N., & Morgan, B.J. (2016). Revisiting the debate: Does exercise build strong bones in the mature and senescent skeleton? Frontiers in Physiology, 7, 369.
View publication via DOI: DOI:10.3389/fphys.2016.00369

Barnes, J.N. (2015). Exercise, cognitive function, and aging. Advances in Physiology Education, 30, 55-62.
View publication via DOI: DOI:10.1152/advan.00101.2014

Taylor, J.L., Hines, C.N., Nicholson, W.T., Joyner, M.J., & Barnes, J.N. (2014). The effect of aging and indomethacin on forearm reactive hyperemia in healthy adults. Experimental Physiology, 99(6), 859-867.
View publication via DOI: DOI:10.1113/expphysiol.2014.077941

Barnes, J.N., Hart, E.C., Curry, T.B., Nicholson, W.T., Eisenach, J.H., Wallin, B.G., Charkoudian, N., & Joyner, M.J. (2014). Aging enhances autonomic support of blood pressure in women. Hypertension, 63(2), 303-308.
View publication via DOI: DOI:10.1161/HYPERTENSIONAHA.113.02393

Miller, V.M., Garovic, V.D., Kantarci, K., Barnes, J.N., Jayachandran, M., Joyner, M.J., Schuster, L.T., & Rocca, W.A. (2013). Sex-specific risk for cardiovascular disease and cognitive decline. Biology of Sex Differences, 4(1), 6.
View publication via DOI: DOI:10.1186/2042-6410-4-6

Barnes, J.N., Taylor, J.L., Kluck, B.N., Johnson, C.P., & Joyner, M.J. (2013). Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults. Journal of Applied Physiology, 114(10), 1383-1387.
View publication via DOI: DOI:10.1152/japplphysiol.01258

Barnes, J.N., Casey, D.P., Hines, C.N., Nicholson, W.T., & Joyner, M .J. (2012). Association of cardiac baroreflex sensitivity with blood pressure transients: The influence of sex and menopausal status. Frontiers in Physiology, 3, 187.
View publication via DOI: DOI:10.3389/fphys.2012.00187

Barnes, J.N., Schmidt, J.E., Nicholson, W.T., & Joyner, M.J. (2012). Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia. Journal of Applied Physiology, 112, 1884-1890.
View publication via DOI: DOI:10.1152/japplphysiol.01270.2011

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