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Biology of Aging

Mary Hayney

Mary S. Hayney

Pharm.D., BCPS, University of Minnesota
Professor, School of Pharmacy

Vaccines and Vaccine Preventable Diseases

My research efforts are focused on improving our understanding of the cell mediated immune response to vaccines. Currently, vaccines are licensed based on their ability to induce an antibody response and prevent infection. This approach largely ignores the contribution of T cells to protective immunity.

My laboratory is studying cytokine responses as markers of T cell activation following immunization. We found interesting positive correlations between psychosocial factors and cytokine production following influenza and hepatitis A immunization in a group of aging adults. Several examples of psychological stress negatively affecting vaccine response have been found, but ours may be the first report of high well being predicting good vaccine response. We are continuing this work in a cohort of elderly women. This work contributes to investigations of the biology behind lower immune responses following immunization in older individuals. We hope to develop strategies to improve the vaccine response in the elderly-either with better vaccines or alternative vaccination strategies.

In addition to these studies, we are also pursuing our interest in improving the health of individuals in Wisconsin. We completed a pilot study to measure tetanus antibody concentrations in Wisconsin farmers. Surprisingly, we found that the Wisconsin farmers had higher tetanus antibody concentrations than nonfarmers in our study. Consistent with the findings of other investigators, we found that older women were much more likely to be unprotected from tetanus than younger individuals.

Our laboratory is also interested in strategies to vaccinate patients who have received solid organ transplants. This patient population is a particularly high risk. They receive immunosuppressive drugs to prevent organ rejection, but this lowers their ability to fend off infection and their ability to mount vigorous responses to immunization.

As a pharmacist, I maintain a clinical interest in the section of the population that is the highest user of medications-the elderly. This population is at higher risk of adverse events associated with medication use because of biology and the use of multiple medications simultaneously.

Representative Publications
Rose, W. E., Shukla, S. K., Berti, A. D., Hayney, M. S., Henriquez, K. M., ... Sakoulas, G. (2017). Increased endovascular staphylococcus aureus inoculum is the link between elevated serum IL-10 concentrations and mortality in patients with bacteremia. Clinical Infectious Diseases, 64(10), 1406-1412.
View publication via DOI: DOI:10.1093/cid/cix157

Caldera, F., Farraye, F.A., Wasan, S., & Hayney, M.S. (2017). Caution when assessing immunity to varicella via antibody testing in inflammatory bowel disease patients. Inflammatory bowel diseases, 23(10), E50-E51.
View publication via DOI: DOI:10.1097/MIB.0000000000001239

Rohde, K.A., Schlei, Z.W., Katers, K.M., Weber, A.K., Brokhof, M.M., Hawes, D.S., Radford, K.L., Francois, M.L., Menninga, N.J., Cornwell, R., Benca, R., Hayney, M.S., & Dopp, J.M. (2017). Insomnia and relationship with immunosuppressant therapy after lung transplantation. Progress in transplantation, 27(2), 167-174.
View publication via DOI: DOI:10.1177/1526924817699960

Hayney, MS, Henriquez, K.M., Barnet, J.H., Ewers, T., Champion, H.M., Flannery, S., & Barrett, B. (2017). Serum IFN-gamma-induced protein 10 (IP-10) as a biomarker for severity of acute respiratory infection in healthy adults. Journal of clinical virology, 90, 32-37.
View publication via DOI: DOI:10.1016/j.jcv.2017.03.003

Henriquez, K. M., Hayney, M. S., Rakel, D. P., & Barrett, B. (2016). Procalcitonin levels in acute respiratory infection. Viral Immunology, 29(2), 128-131.
View publication via DOI: DOI:10.1089/vim.2015.0106

Miller, R. M., Rohde, K. A., Tingle, M. T., Moran, J. J., & Hayney, M. S. (2016). Antibody responses to influenza vaccine in pre-and post-lung transplant patients. Clinical Transplantation, 30(5), 606-612.
View publication via DOI: DOI:10.1111/ctr.12726

Caldera, F., & Hayney, M. S. (2016). Barriers to administration of herpes zoster immunization in patients with inflammatory bowel disease. Inflammatory Bowel Diseases, 22(11), E44.
View publication via DOI: DOI:10.1097/mib.0000000000000942

Menninga, N. J., Rohde, K. A., Schlei, Z. W., Katers, K. M., Weber, A. K., Brokhof, M. M., ... Hayney, M. S., & Dopp, J. M. (2016). Restless legs syndrome following lung transplantation: Prevalence and relationship with tacrolimus exposure. Progress in Transplantation, 26(2), 149-156.
View publication via DOI: DOI:10.1177/1526924816640980

Henriquez, K. M., Hayney, M. S., Xie, Y., Zhang, Z, & Barrett, B. (2014). Association of interleukin-8 and neutrophils with nasal symptom severity during acute respiratory infection. Journal of Medical Virology, 87(2), 330-337.
View publication via DOI: DOI:10.1002/jmv.24042

Long, A.J., Worzella, S.L., Moran, J.J., & Hayney, M.S. (2014). Influenza vaccine antibody response and 6-month persistence in lung transplant recipients using two definitions of seroprotection. Transplantation.

Hayney, M. S., Coe, C. L., Muller, D., Obasi, C. N., Backonja, U., Ewers, T., & Barrett, B. (2013). Age and psychological influences on immune responses to trivalent inactivated influenza vaccine in the meditation or exercise for preventing acute respiratory infection (MEPARI) trial. Human Vaccines and Immunotherapeutics, 10(1). Advance online publication.
View publication via DOI: DOI:10.4161/hv.26661

Barrett, B., Hayney, M.S., Muller, D., Rakel, D., Ward, A., Obasi, O.N., ... Coe, C.L. (2012). Meditation or Exercise for Preventing Acute Respiratory Infection: A Randomized Controlled Trial. Annals of Family Medicine, 10(4), 337-346.
View publication via DOI: DOI:10.1370/afm.1376

Baughman, R. P., Meyer, K. C., Nathanson, I., Angel, L., Bhorade, S. M., Chan, K. M., . . . Hayney, M. S., . . . Whelan, T. (2012). Executive summary: Monitoring of nonsteroidal immunosuppressive drugs in patients with lung disease and lung transplant recipients: American college of chest physicians evidence-based clinical practice guidelines. Chest, 142(5), 1284-1288.
View publication via DOI: DOI:10.1378/chest.12-1075

Vardeny, O., Moran, J.J., Sweitzer, N.K., Johnson, M.R., & Hayney, M.S. (2010). Decreased T-cell responses to influenza vaccination in patients with heart failure. Pharmacotherapy, 30(1), 10-6.
Click here to download this publication.
View publication via DOI: DOI:10.1592/phco.30.1.10

Dopp, J.M., Wiegert, N.A., Moran, J.J., Francois, M.L., Radford, K.L., Thomas, H., Love, R.B., & Hayney, M.S. (2009). Effect of annual influenza immunization on antibody response in lung transplant patients. Prog Transplant, 19(2), 153-159.

Vardeny, O., Sweitzer, N.K., Detry, M.A., Moran, J.M., Johnson, M.R., & Hayney, M.S. (2009). Decreased immune responses to influenza vaccination in patients with heart failure. Journal of Cardiac Failure, 15(4), 368-373.
View publication via DOI: DOI:10.1016/j.cardfail.2008.11.009

Hayney, M.S., Moran, J.J.M., Weigert, N.A., & Burlingham, W.J. (2008). Lung transplant patients' T cell responses to influenza vaccine viruses between seasons. Vaccine, 62, 2596-2600.
View publication via DOI: DOI:10.1016/j.vaccine.2008.03.012

Bobadilla, J.L., Love, R.B., Jankowska-Gan, E., Haynes, L.D., Braun, R.K., Hayney, M.S., Munoz del Rio, A.J., Greenspan, D.S., Heidler, K.M., Cummings, O.W., Takekazu, I., Brand, D., Presson, R., Burlingham, W.J., & Wilkes, D.S. (2008). Collagen type V specific memory T-cells and primary graft dysfunction in lung transplantation. Am. J. Resp. Crit. Care, 177(6), 660-8.
View publication via DOI: DOI:10.1164/rccm.200612-1901OC

Bartell, J.C., Roberts, K.A., Schutte, N.J., Sherman, K.C., Muller, D., & Hayney, M.S. (2008). Effect of needle temperature on pain ratings following injection. Clin. J. Pain, 24(3), 260-264.
View publication via DOI: DOI:10.1097/AJP.0b013e31816111c0

Bobadilla, J.L., Love, R.B., Jankowska-Gan, E., Xu, Q., Haynes, L.D., Braun, R.K., Hayney, M.S., del Rio, A., deOliveira, N., Meyer, K., et al. (2008). TH-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation. Am. J. Respir. Crit. Care Med., 177, 660-668.
View publication via DOI: DOI:10.1164/rccm.200612-1901OC

Friedman, E.M., Hayney, M., Love, G.D., Singer, B.H., & Ryff, C.D. (2007). Plasma interleukin-6 and soluble IL-6 receptors are associated with psychological well-being in aging women. Health Psychology, 26, 305-313.
View publication via DOI: DOI:10.1037/0278-6133.26.3.305

Hayney, M.S., Weigert, N.A., Pelsue, F.L., Fohl, R.M., Jankowska-Gan, E., Love, R.B., & Burlingham, W.J. (2007). T cell responses to hepatitis B surface antigen in lung transplant patients. Pharmacotherapy, 27(9), 1248-52.
View publication via DOI: DOI:10.1592/phco.27.9.1248

Dopp, J.M., Wiegert, N.A., Moran, J.J., Muller, D., Weber, S., & Hayney, M.S. (2007). Humoral immune responses to influenza vaccination in patients with obstructive sleep apnea. Pharmacotherapy, 27(9), 1248-5.
View publication via DOI: DOI:10.1592/phco.27.11.1483

Burlingham, W.J., Love, R.B., Jankowska-Gan, E., Haynes, L.D., Xu, Q., Bobadilla, J.L., Meyer, K.C., Hayney, M.S., Braun, R.K., Greenspan, D.S., Gopalakrishnan, B., Yoshida, S., Brand, D.D., Smith, G.N., Jr., Cummings, O.W., Cai, J., & Wilkes, D.S. (2007). Col V specific, IL17- and monokine-dependent cellular immunity predisposes to obliterative bronchiolitis after lung transplantation. J. Clin. Invest., 117(11), 3498-3506.
View publication via DOI: DOI:10.1172/JCI28031

Friedman, E.M., Hayney, M.S., Love, G.D., Urry, H.L., Rosenkranz, M.A., Davidson, R.J., Singer, B.H., & Ryff, C.D. (2005). Social relationships, sleep quality, and interleukin-6 in aging women. PNAS, 102, 18757-18762.
View publication via DOI: DOI:10.1073/pnas.0509281102

Hayney, M.S., Love, G.D., Carlberg, B.M., Buck, J.M. & Muller, D. (2003). Tetanus Seroprevalence among farmers: A preliminary study. The Journal of Rural Health, 19(2), 109-112.
View publication via DOI: DOI:10.1111/j.1748-0361.2003.tb00549.x

Hayney, M.S., Love, G.D., Buck, J. M., Ryff, C.D., Singer, B., & Muller, D. (2003). The association between psychosocial factors and vaccine induced-cytokine production. Vaccine, 21, 2428-243.
View publication via DOI: DOI:10.1016/S0264-410X(03)00057-4

Hayney, M.S. (2002). Pharmacogenomics and infectious diseases: Impact on drug response and applications to disease management. Am. J. Health-Syst. Pharm., 59, 1626-1631.

Arrowood, J.R., & Hayney, M.S. (2002). Immunization recommendations for adults with cancer. Ann. Pharmacother., 36, 1219-29.
View publication via DOI: DOI:10.1345/aph.1A277

Hayney, M.S., Hammes, R.J., Fine, J.P., & Bianco, J.A. (2002). Effect of influenza immunization on CYP3A4 activity. Vaccine, 20, 858-861.
View publication via DOI: DOI:10.1177/0091270003260330

Hayney, M.S., & Buck, J.M. (2002). Effect of age and degree of immune activation on CYP3A4 activity after influenza immunization. Pharmacotherapy, 22(10), 1235-1238.

Steiner, M.A., Vermeulen, L.C., Mullahy, J., & Hayney, M.S. (2002). Factors influencing decisions regarding influenza vaccination and treatment: A survey of healthcare workers. Infect. Cont. Hosp. Epidemiol., 23(10), 625-627.

Raeder, C.K., & Hayney, M.S. (2000). Immunology of varicella immunization in the elderly. Ann. Pharmacother., 34, 228-34.
View publication via DOI: DOI:10.1345/aph.19121

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