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Mark Markel

Mark D. Markel

D.V.M., University of California at Davis; Ph.D., Mayo Graduate School of Medicine;
Dean, School of Veterinary Medicine;
Vilas Distinguished Achievement Professor
mark.markel@wisc.edu
http://www.vetmed.wisc.edu/people/markelm


Enhancing Limb Function Through the Regeneration of Bone, Cartilage and Tendon.

The Comparative Orthopaedic Research Laboratory which I co-direct is focused on the regeneration of bone, cartilage, and tendon designed to enhance limb function. In bone, we have focused our efforts on the creation of bioengineered scaffolds which incorporate cytokines such as various bone morphogenetic proteins in order to enhance healing of critical sized bone defects. In cartilage, we have helped develop bioengineered constructs through the use of allogeneic, xenogeneic, and autogeneic chondrocytes and/or mesenchymal stem cells to create cartilage transplants for critical-sized cartilage defects. In tendon, we are investigating the incorporation of a variety of proteins within biomineral coatings of suture material to enhance the healing and long term function of tendons that have been injured.



Representative Publications
Biedrzycki, A. H., Grant, B. D., Nemke, B., Markel, M. D., & Morello, S. L. (2016). Arthrodesis of the equine centrodistal and tarsometatarsal joints using a single modified kerf-cut cylinder. Veterinary and Comparative Orthopaedics and Traumatology, 29(3), 227-231.
View publication via DOI: DOI:10.3415/vcot-15-10-0167

Biedrzycki, A. H., Grant, B. G., Nemke, B., Morello, S. L., & Markel, M. D. (2016). In vitro biomechanical evaluation of four surgical techniques for fusion of equine centrodistal and tarsometatarsal joints. American Journal of Veterinary Research, 77(10), 1071-1081.
View publication via DOI: DOI:10.2460/ajvr.77.10.1071

Racette, M., Al saleh, H., Waller, K. R., 3rd, Bleedorn, J. A., McCabe, R. P., Vanderby, R., Jr., ... Markel, M. D., ... Muir, P. (2016). 3D FSE Cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties. Veterinary Journal, 209, 150-155.
View publication via DOI: DOI:10.1016/j.tvjl.2015.10.055

Rustom, L. E., Boudou, T., Lou, S., Pignot-Paintrand, I., Nemke, B. W., Lu, Y., ... Markel, M. D., ... Wagoner Johnson, A. J. (2016). Micropore-induced capillarity enhances bone distribution in vivo in biphasic calcium phosphate scaffolds. Acta Biomaterialia, 44, 144-154.
View publication via DOI: DOI:10.1016/j.actbio.2016.08.025

Martin, J. A., Biedrzycki, A. H., Lee, K. S., DeWall, R. J., Brounts, S. H., Murphy, W. L., ... Markel, M. D., ...Thelen, D. G. (2015). In vivo measures of shear wave speed as a predictor of tendon elasticity and strength. Ultrasound in Medicine and Biology, 41(10), 2722-2730.
View publication via DOI: DOI:10.1016/j.ultrasmedbio.2015.06.008

Rowe-Guthrie, K. M., Markel, M. D., & Bleedorn, J. A. (2015). Mechanical evaluation of locking, nonlocking, and hybrid plating constructs using a locking compression plate in a canine synthetic bone model. Veterinary Surgery, 44(7), 838-842.
View publication via DOI: DOI:10.1111/vsu.12368

Bleedorn, J. A., Sullivan, R., Lu, Y., Nemke, B., Kalscheur, V., & Markel, M. D. (2014). Percutaneous lovastatin accelerates bone healing but is associated with periosseous soft tissue inflammation in a canine tibial osteotomy model. Journal of Orthopaedic Research, 32(2), 210-216.
View publication via DOI: DOI:10.1002/jor.22502

Thiede, R.M., Lu, Y., & Markel, M.D. (2012). A review of the treatment methods for cartilage defects. Veterinary and Comparative Orthopaedics and Traumatology, 4, 263-272.
View publication via DOI: DOI:10.3415/VCOT-11-05-0070

Lu, Y., Lee, J. S., Nemke, B., Graf, B. K., Royalty, K., Illgen Iii, R., . . . Markel, M. D., & Murphy, W. L. (2012). Coating with a modular bone morphogenetic peptide promotes healing of a bone-implant gap in an ovine model. PLoS ONE, 7(11), 1-7.
View publication via DOI: DOI:10.1371/journal.pone.0050378

Lu, Y., Lee, J.S., Nemke, B., Baer, G., Graf, B., Murphy, W.L., & Markel, M.D. (2011). Histologic evaluation of suture material loaded with basic fibroblast growth factor (bFGF) on acute rotator cuff repair in an ovine model. Current Orthopaedic Practice, 22(5), 425-431.
View publication via DOI: DOI:10.1097/BCO.0b013e3182282cd7

Sample, S.J., Collins, R.J., Wilson, A.P., Racette, M.A., Behan, M., Markel, M.D., Kalscheur, V.L., Hao, Z., & Muir, P. (2010). Systemic effects of ulna loading in male rats during functional adaptation. Journal of Bone and Mineral Research, 25(9), 2016-2028.
View publication via DOI: DOI:10.1002/jbmr.101

McCarthy, J.J., Noonan, K.J., Nemke, B., & Markel, M. (2010). Guided growth of the proximal femur: A pilot study in the lamb model. Journal of Pediatric Orthopaedics, 30(7), 690-694.
View publication via DOI: DOI:10.1097/BPO.0b013e3181edef71

Lee, J.S., Lu, Y., Baer, G.S., Markel, M.D., & Murphy, W.L. (2010). Controllable protein delivery from coated surgical sutures. Journals of Material Chemistry, 20, 8894-8903.
View publication via DOI: DOI:10.1039/C0JM01389G

Lu, Y., Markel, M.D., Nemke, B., Lee, J.S., Graf, B.K., & Murphy, W.L. (2009). Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model. Arthroscopy, 25(12), 1427-1434.
Click here to download this publication.
View publication via DOI: DOI:10.1016/j.arthro.2009.06.008

Lu, Y., Markel, M.D., Nemke, B., Wynn, S., & Graf, B. (2009). Comparison of single- versus double-tunnel tendon-to-bone healing in an ovine model: A biomechanical and histological analysis. American Journal of Sports Medicine, 37(3), 512-517.
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View publication via DOI: DOI:10.1177/0363546508327543

Lu, Y., Nemke, B., Lorang, D.M., Trip, R., Kobayashi, H., & Markel, M.D. (2009). Comparison of a new braid fixation system to an interlocking intramedullary nail for tibial osteotomy repair in an ovine model. Veterinary Surgery, 38(4), 467-76.
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View publication via DOI: DOI:10.1111/j.1532-950X.2009.00517.x

Schaefer, S.L., Lu, Y., Seeherman, H., Li, X.J., Lopez, M.J., & Markel, M.D. (2009). Effect of rhBMP-2 on tibial plateau fractures in a canine model. Journal of Orthopaedic Research, 27(4), 466-71.
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View publication via DOI: DOI:10.1002/jor.20647

Steiner, S., Lu, Y., Menetski, J.P., Milovancev, M., Nemke, B., & Markel, M.D. (2009). Effects of firocoxib therapy on progression of osteoarthritis in a canine model. Current Orthopaedic Practice, 20(3), 304-312.
View publication via DOI: DOI:10.1097/BCO.0b013e3181981d4d

Lu, Y., Markel, M.D., Nemke, B., Lee, J.S., Graf, B.K., & Murphy, W.L. (2009). Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model. Arthroscopy: The Journal of Arthroscopic and Related Surgery, 25(12), 1427-1434.
View publication via DOI: DOI:10.1016/j.arthro.2009.06.008

Kaplan, L.D., Lu, Y., Snitzer, J.R., Nemke, B., Hao, Z.L., Biro, S.M., Albiero, W.V., Markel, M.D., Baum, S.Z., & Popkin, C. (2009). The effect of early hyaluronic acid delivery on the development of acute articular cartilage lesions in a sheep model. American Journal of Sports Medicine, 37(12), 2323-2327.
View publication via DOI: DOI:10.1177/0363546509339579

Lopez, M.J., Davis, K.M., Jeffrey-Borger, S.L., Markel, M.D., & Rettenmund, C. (2009). Inter-observer repeatability of measurements on computed tomography images of lax canine hip joints from youth to maturity. Veterinary Surgery, 38(8), 920-926.
View publication via DOI: DOI:10.1111/j.1532-950X.2009.00580.x

Lopez, M.J., Lewis, B.P., Swaab, M.E., & Markel, M.D. (2008). Relationships among measurements obtained by use of computed tomography and radiography and scores of cartilage microdamage in hip joints with moderate to severe joint laxity in dogs. Am. J. Vet. Res., 69, 362-370.
View publication via DOI: DOI:10.2460/ajvr.69.3.362

Sample, S.J., Behan, M., Smith, L., Oldenhoff, W.E., Markel, M.D., Kalscheur, V.L., Hao, Z., Miletic, V., & Muir, P. (2008). Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones. J. Bone Miner. Res., 23, 1372-1381.
View publication via DOI: DOI:10.1359/jbmr.080407

Perrier, M., Lu Y., Nemke, B., Kobayashi, H., Peterson, A., & Markel, M.D. (2008). Acceleration of second and fourth metatarsal fracture healing with recombinant human bone morphogenetic protein-2/calcium phosphate cement in horses. Vet. Surg., 37, 648-655.
View publication via DOI: DOI:10.1111/j.1532-950X.2008.00431.x

Edwards, R.B., Lu, Y., Cole, B.J., Muir, P., & Markel, M.D. (2008). Comparison of radiofrequency treatment and mechanical debridement of fibrillated cartilage in an equine model. Veterinary and Comparative Orthopaedics and Traumatology, 21, 41-48.

Pluhar, G.E., Manley, P.A., Heiner, J.P., Vanderby, R., & Markel, M.D. (2007). Gluteal muscle attachment during proximal femoral reconstruction in a canine model. J. Orthop. Res., 25, 208-220.
View publication via DOI: DOI:10.1002/jor.20283

Edwards, R.B., Lu, Y., Bogdanske, J.J., Muir, P., & Markel, M.D. (2007). Comparison of mechanical debridement and radiofrequency energy for chondroplasty in an in vivo equine model of partial thickness cartilage injury. Osteoarthritis Cart., 15, 169-178.
View publication via DOI: DOI:10.1016/j.joca.2006.06.021

Muir, P., Sample, S.J., Barrett, J.G., McCarthy, J., Vanderby, R., Markel, M.D., Prokuski, L.J., & Kalscheur, V.L. (2007). Effect of fatigue loading and associated matrix microdamage on bone blood flow and interstitial fluid flow. Bone, 40(4), 948-956.
View publication via DOI: DOI:10.1016/j.bone.2006.11.012

Muir, P., McCarthy, J., Radtke, C.L., Markel, M.D., Santschi, E.M., Scollary, M.C., & Kalscheur, V.L. (2006). Role of endochondral ossification of articular cartilage and functional adaptation of the subchondral plate in development of fatigue microcracking of joints. Bone, 38, 342-349.

Lu, Y., Markel, M.D., Swain, C., & Kaplan, L.D. (2006). Development of partial thickness articular cartilage injury in an ovine model. J. Orthop. Res., 24, 1974-1982.
View publication via DOI: DOI:10.1002/jor.20249

Daubs, B., Markel, M.D., & Manley, P.A. (2006). Histomorphometric analysis of articular cartilage, zone of calcified cartilage, and subchondral bone plate in femoral heads from clinically normal dogs and dogs with moderate or severe osteoarthritis. Am. J. Vet. Res., 67, 1719-1724.
View publication via DOI: DOI:10.2460/ajvr.67.10.1719

Sicard, G.K., Markel, M.D., & Manley, P.A. (2005). Histomorphometric analysis of the proximal portion of the femur in dogs with moderate osteoarthritis. Am. J. Vet. Res., 66, 150-155.
View publication via DOI: DOI:10.2460/ajvr.2005.66.150

Lu, Y., Adkisson, D., Bogdanske, J., Kalscheur, V., Maloney, W., Cheung, R., Grodzinsky, A.J., Hruska, K.A., & Markel, M.D. (2005). In vivo transplantation of neonatal ovine neocartilage allografts: Determining the effectiveness of tissue transglutaminase. J. Knee Surg., 18, 31-42.

Meyer, M.L., Lu, Y., & Markel, M.D. (2005). Effects of radiofrequency energy on human chondromalacic cartilage: an assessment of insulation material properties. IEEE Trans. Biomed. Eng., 52, 702-710.

Da Costa-Gomez, T.M., Barrett, J.G., Sample, S.J., Radtke, C.L., Kalscheur, V.L., Lu, Y., Markel, M.D., Santschi, E.M., Scollary, M.C., Muir, P. (2005). Up-regulation of site-specific remodeling without accumulation of microcracking and loss of osteocytes. Bone, 37, 16-24.
View publication via DOI: DOI:10.1016/j.bone.2004.12.016

Williams, J.M., Virdi, A.S., Pylawka, T.K., Edwards, R.B., III, Markel, M.D., & Cole, B.J. (2005). Prolonged-fresh preservation of intact whole canine femoral condyles for the potential use as osteochondral allografts. J. Orthop. Res., 23, 831-837.
View publication via DOI: DOI:10.1016/j.orthres.2004.07.007

Bergh, M.S., Muir, P., Markel, M.D., & Manley, P.A. (2004). Femoral bone adaptation to stable long-term cemented total hip arthroplasty in dogs. Vet. Surg., 33, 214-220.
View publication via DOI: DOI:10.1111/j.1532-950X.2004.04032.x

Bergh, M.S., Muir, P., Markel, M.D., Manley, P.A. (2004). Femoral bone adaptation to unstable long-term cemented total hip arthroplasty in dogs. Vet. Surg., 33, 238-245.

Colopy, S.A., Benz-Dean, J., Barrett, J.G., Sample, S.J., Lu, Y., Danova, N.A., Kalscheur, V.L., Vanderby, R., Markel, M.D., & Muir, P. (2004). Response of the osteocyte syncitium adjacent to and distant from microcracks during adaptation to cyclic fatigue loading. Bone, 35, 881-891.
View publication via DOI: DOI:10.1016/j.bone.2004.05.024

Noonan, K.J., Farnum, C.E., Leiferman, E.M., Lampl, M., Markel, M.D., & Wilsman, N.J. (2004). Growing pains: Are they due to increased growth during recumbency as documented in a lamb model? J. Pediatr. Orthop., 24, 726-731.

Edwards, R.B., Lu, Y., Nho, S., Cole, B.J., & Markel, M.D. (2002). Thermal chondroplasty of chondromalacic human cartilage: An ex vivo comparison of bipolar and monopolar radiofrequency devices. Am. J. Sports. Med., 30, 90-97.

Edwards, R.B., Lu, Y., Rodriguez, E., & Markel, M.D. (2002). Thermometric determination of cartilage matrix temperatures during thermal chondroplasty: Comparison of bipolar and monopolar radiofrequency devices. Arthroscopy, 18, 339-346.
View publication via DOI: DOI:10.1053/jars.2002.29893

Pluhar, G.E., Heiner, J.P., Manley, P.A., Bogdanske, J.J., Vanderby, R., & Markel, M.D. (2002). Comparison of three methods of gluteal muscle attachment to an allograft/endoprosthetic composite in a canine model. J. Orthop. Res., 18, 56-63.

Lu, Y., Edwards, R.B., Kalscheur, V.L., Nho, S., Cole, B.J., & Markel, M.D. (2001). Effect of bipolar radiofrequency energy on human articular cartilage: Comparison of confocal laser microscopy and light microscopy. Arthroscopy, 17, 117-123.
View publication via DOI: DOI:10.1053/jars.2001.21903

Pluhar, G.E., Manley, P.A., Heiner, J.P, Vanderby, R., Seeherman, H.J., & Markel, M.D. (2001). The effect of recombinant human bone morphogenetic protein-2 on femoral reconstruction with an intercalary allograft in a dog model. J. Orthop. Res., 19, 308-317.
View publication via DOI: DOI:10.1016/S0736-0266(00)90002-0

Hayashi, K., & Markel, M.D. (2001). Thermal capsulorraphy treatment of shoulder instability: Basic science. Clin. Orthop., 390, 59-72.

Lu, Y., Hayashi, K., Edwards, R.B., Fanton, G.S., Thabit, G., & Markel, M.D. (2000). The effect of monopolar radiofrequency treatment pattern on joint capsular healing: In vitro and in vivo studies using an ovine model. Am. J. Sports Med., 28, 711-719.
View publication via DOI: DOI:10.1053/jars.2000.7690

Lu, Y., Hayashi, K., Hecht, P., Fanton, G.S., Thabit, G., Cooley, A.J., Edwards, R.B., & Markel, M.D. (2000). The effect of monopolar radiofrequency energy on partial-thickness defects of articular cartilage. Arthroscopy, 16, 527-536.

Osmond, C., Hecht, P., Hayashi, K., Hansen, S., Fanton, G.S., Thabit, G., & Markel, M.D. (2000). Comparative effects of laser and radiofrequency energy on joint capsule. Clin. Orthop., 375, 286-294.

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