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Annual
COLLOQUIUM
ON AGING
:

Event Speakers

IOA Newsletter,
AGING NEWS:

Cover of Aging News

MIDUS
Newsletters
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MIDUS Inequality newsletter cover

Training Grant-
Biology of Aging
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Mark Sager

Mark A. Sager

M.D., University of Wisconsin-Madison
Professor Emeritus, Department of Medicine
Director, Wisconsin Alzheimer's Institute
masager@wisc.edu
http://www.wai.wisc.edu/aboutus/facultystaff/sager.html


Preventing Alzheimer's Disease

Alzheimer's disease (AD) currently affects between 5% and10% of the population aged 65 and older and is the most frequent cause of institutionalization for long-term care in the United States. In Wisconsin, the number of persons affected by Alzheimer's disease is expected to increase by 58% from 103,000 to 163,000 persons over the next 25 years. The expected rapid increase in the number of persons with AD will translate into higher public and private long-term care costs and significant caregiver burdens for affected families.

Current data indicate that AD is a lifelong disease with a prolonged pre-clinical phase during which prevention strategies would be most effective in delaying or preventing its onset. Neuritic plaques and neurofibrillary tangles, the pathologic hallmarks of AD, have been found in adults without dementia, suggesting that the neuronal deficits leading to AD begin years before any symptoms develop. As in other chronic degenerative diseases of aging, a person's risk of developing symptoms of AD is most likely the result of genetic, environmental, socioeconomic and lifestyle factors which interact to determine age of onset. Because of this, a person's risk of developing symptoms of AD is potentially modifiable, either by changes in the environment or lifestyle or through external interventions.

The Wisconsin Alzheimer's Institute currently is developing a statewide registry of over 1000 participants. This registry will support genetic, epidemiologic and clinical studies at the University of Wisconsin (UW) to identify and evaluate those factors which may delay or prevent the onset of AD. Each registry participant undergoes a 2-hour battery of neuropsychological testing, a complete detailed health history assessment and laboratory testing for risk factors for AD. Registry participants also have the opportunity to participate in University-sponsored research that could contribute to our understanding of how to prevent AD in the future.

This exciting research initiative involves researchers throughout the UW Madison campus including faculty from Neurology, Medicine, Geriatrics and Gerontology.



Representative Publications
Law, L. L., Schultz, S. A., Boots, E. A., Einerson, J. A., Dougherty, R. J., Oh, J. M., Korcarz, C. E., Edwards, D. F., ... Bendlin, B. B., Carlsson, C. M., Asthana, S., Hermann, B. P., Sager, M. A., Johnson, S. C., ... & Okonkwo, O. C. (2017). Chronotropic response and cognitive function in a cohort at risk for Alzheimer's disease. Journal of Alzheimer's Disease, 56(1), 351-359.
View publication via DOI: DOI:10.3233/jad-160642

Dean, D. C. I., Hurley, S. A., Kecskemeti, S. R., O'Grady, P., Canda, C., Davenport-Sis, N. J., ... Asthana, S., Sager, M. A., Johnson, S. C., Alexander, A., & Bendlin, B. B. (2017). Association of amyloid pathology with myelin alteration in preclinical Alzheimer's disease. JAMA Neurology, 74(1), 41-49.
View publication via DOI: DOI:10.1001/jamaneurol.2016.3232

Dougherty, R. J., Schultz, S. A., Boots, E. A., Ellingson, L. D., Meyer, J. D., Van Riper, S., Stegner, A. J., Edwards, D. F., ... Bendlin, B. B., Asthana, S., ... Sager, M. A., ... Johnson, S. C., Okonkwo, O. C., & Cook, D. B. (2017). Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease. Brain and Behavior. Advance online publication.
View publication via DOI: DOI:10.1002/brb3.625

Darst, B. F., Koscik, R. L., Racine, A. M., Oh, J. M., Krause, R. A., Carlsson, C. M., ... Bendlin, B. B., Okonkwo, O. C., ... Sager, M. A., Asthana, S., Johnson, S. C., & Engelman, C. D. (2017). Pathway-specific polygenic risk scores as predictors of amyloid-beta deposition and cognitive function in a sample at increased risk for Alzheimer's disease. Journal of Alzheimer's Disease, 55(2), 473-484.
View publication via DOI: DOI:10.3233/jad-160195

Clark, L. R., Racine, A. M., Koscik, R. L., Okonkwo, O. C., Engelman, C. D., Carlsson, C. M., Asthana, S., Bendlin, B. B., ... Sager, M. A., Christian, B. T., & Johnson, S. C. (2016). Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin registry for Alzheimer's prevention study. Alzheimer's & Dementia, 12(7), 805-814.
View publication via DOI: DOI:10.1016/j.jalz.2015.12.009

Ly, M., Adluru, N., Destiche, D.J., Lu, S.Y., Oh, J.M., Hoscheidt, S.M., Alexander, A.L., Okonkwo, O.C., Rowley, H.A., Sager, M.A., Johnson, S.C., & Bendlin, B.B. (2016). Fornix microstructure and memory performance is associated with altered neural connectivity during episodic recognition. Journal of the International Neuropsychological Society, 22(2), 191-204.
View publication via DOI: DOI:10.1017/S1355617715001216

Melah, K. E., Lu, S. Y., Hoscheidt, S. M., Alexander, A. L., Adluru, N., Destiche, D. J., ... Okonkwo, O. C., ... Sager, M. A., Asthana, S., Johnson, S. C., & Bendlin, B. B. (2016). Cerebrospinal fluid markers of Alzheimer's disease pathology and microglial activation are associated with altered White matter microstructure in asymptomatic adults at risk for Alzheimer's disease. Journal of Alzheimer's Disease, 50(3), 873-886.
View publication via DOI: DOI:10.3233/jad-150897

Koscik, R. L., Berman, S. E., Clark, L. R., Mueller, K. D., Okonkwo, O. C., Gleason, C. E., Hermann, B. P., Sager, M. A., & Johnson, S. C. (2016). Intraindividual cognitive variability in middle age predicts cognitive impairment 8-10 years later: Results from the Wisconsin registry for Alzheimer's prevention. Journal of the International Neuropsychological Society, 22(10), 1016-1025.
View publication via DOI: DOI:10.1017/s1355617716

Mueller, K. D., Koscik, R. L., Turkstra, L. S., Riedeman, S. K., LaRue, A., Clark, L. R., Hermann, B., Sager, M. A., & Johnson, S. C. (2016). Connected language in late middle-aged adults at risk for Alzheimer's disease. Journal of Alzheimer's Disease 54(4), 1539-1550.
View publication via DOI: DOI:10.3233/jad-160252

Merluzzi, A. P., Dean, D. C., 3rd, Adluru, N., Suryawanshi, G. S., Okonkwo, O. C., Oh, J. M., Hermann, B. P., Sager, M. A., Asthana, S., Zhang, H., Johnson, S. C., Alexander, A. L., & Bendlin, B. B. (2016). Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging. Neurobiology of Aging, 43, 79-88.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2016.03.026

Clark, L. R., Koscik, R. L., Nicholas, C. R., Okonkwo, O. C., Engelman, C. D., Bratzke, L. C., ... Bendlin, B. B., Carlsson, C. M., Asthana, S., Sager, M. A., ... Johnson, S. C. (2016). Mild cognitive impairment in late middle age in the Wisconsin registry for Alzheimer's prevention study: Prevalence and characteristics using robust and standard neuropsychological normative data. Archives of Clinical Neuropsychology. Advance online publication.
View publication via DOI: DOI:10.1093/arclin/acw024

Dougherty, R. J., Ellingson, L. D., Schultz, S. A., Boots, E. A., Meyer, J. D., Lindheimer, J. B., ... Edwards, D. F., ... Bendlin, B. B., Asthana, S., ... Sager, M. A., Johnson, S. C., Okonkwo, O. C., & Cook, D. B. (2016). Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease. Alzheimer's & Dementia, 4, 14-17.
View publication via DOI: DOI:10.1016/j.dadm.2016.03.005

Nicholas, C.P., Okonkwo, O.C., Bendlin, B.B., Oh, J.M., Asthana, S., Rowley, H.A., Hermann, B., Sager, M.A., Johnson, S.C. (2015). Posteromedial hyperactivation during episodic recognition among people with memory decline: Findings from the WRAP Study. Brain Imaging and Behavior, 9(4), 690-702.
View publication via DOI: DOI:10.1007/s11682-014-9322-z

Doherty, D.M., Schultz, S.A., Oh, J.M., Koscik, R.L., Dowling, N.M., Barnhart, T.E., Murali, D., Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Rowley, H.A., Asthana, A., Sager, M.A., Christian, B.T., Johnson, S.C., & Okonkwo, O (2015). Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(2), 160-169.
View publication via DOI: DOI:10.1016/j.dadm.2015.01.003

Almeida, R.P., Schultz, S.A., Austin, B.P., Boots, E.A., Dowling, N.M., Gleason, C.E., Bendlin, B.B., Sager, M.A., Hermann, B.P., Zetterberg, H., Carlsson, C.M., Johnson, S.C., Asthana, S., & Okonkwo, O.C. (2015). Effect of cognitive reserve on age-related changes in cerebrospinal fluid biomarkers of Alzheimer Disease. JAMA Neurology, 72(6), 699-706.
View publication via DOI: DOI:10.1001/jamaneurol.2015.0098

Schultz, S.A., Oh, J.M., Koscik, R.L., Dowling, N.M., Gallagher, C.L., Carlsson, C.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Rowley, H.A., Asthana, S., Sager, M.A., Johnson, S.C., & Okonkwo, O.C (2015). Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle-aged adults at risk for AD. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(1), 33-40.
View publication via DOI: DOI:10.1016/j.jalz.2014.05.083

Darst, B. F., Koscik, R. L., Hermann, B. P., La Rue, A., Sager, M. A., Johnson, S. C., & Engelman, C. D. (2015). Heritability of cognitive traits among siblings with a parental history of Alzheimer's disease. Journal of Alzheimer's Disease, 45(4), 1149-1155.
View publication via DOI: DOI:10.3233/jad-142658

Willette, A.A., Bendlin, B.B., Starks, E.J., Birdsill, A.C., Johnson, S.C., Christian, B., Okonkwo, O.C., LaRue, A., Hermann, B., Koscik, R., Jonaitis, E., Sager, M.A., & Asthana, S. (2015). Insulin resistance is associated with lower cerebral glucose uptake in middle-aged adults. JAMA Neurology, 72(9), 1013-1020.
View publication via DOI: DOI:10.1001/jamaneurol.2015.0613

Starks, E.J., O'Grady, P., Hoscheidt, S.M., Racine, A.M., Carlsson, C.M., Zetterberg, H., ... Okonkwo, O.C., Puglielli, L., Asthana, S., ... Anderson, R., ... Sager, M.A., Johnson, S.C., Bendlin, B.B. (2015). Insulin resistance is associated with higher cerebrospinal fluid tau levels in asymptomatic APOE Ε4 carriers. Journal of Alzheimer's Disease, 46(2), 525-33.
View publication via DOI: DOI:10.3233/JAD-150072

Sprecher, K.E., Bendlin, B.B., Racine, A.M., Okonkwo, O.C., Christian, B.T., Koscik, R., Sager, M.A., Asthana, S., Johnson, S.C., & Benca, R.M. (2015). Amyloid Imaging Is Associated With Self-Reported Sleep In Cognitively Healthy Late Middle-Aged Adults. Neurobiology of Aging, 36(9), 2568-76.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2015.05.004

Schultz, S.A., Larson, J., Oh, J., Koscik, R., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Hermann, B.P., Johnson, S.C., Sager, M., LaRue, A., & Okonkwo, O.C. (2015). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease. Brain Imaging & Behavior, 9(4), 729-36.
View publication via DOI: DOI:10.1007/s11682-014-9329-5

Boots, E.A., Schultz, S.A., Almeida, R.P., Oh, J.M., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Sager, M.A., Hermann, B.P., Johnson, S.C., & Okonkwo, O.C. (2015). Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease. Archives of Clinical Neuropsychology, 30(7), 634-42.
View publication via DOI: DOI:10.1093/arclin/acv041

Willette, A. A., Bendlin, B. B., Starks, E. J., Birdsill, A. C., Johnson, S. C., Christian, B. T., Okonkwo, O. C ... Sager, M. A., & Asthana, S. (2015). Association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for Alzheimer disease. JAMA Neurology, 72(9), 1013-1020.
View publication via DOI: DOI:10.1001/jamaneurol.2015.0613

Doherty, B. M., Schultz, S. A., Oh, J. M., Koscik, R. L., Dowling, N. M., Barnhart, T. E., ... Bendlin, B. B., Asthana, S., Sager, M. A., ... Johnson, S. C., & Okonkwo, O. C. (2015). Amyloid burden, cortical thickness, and cognitive function in the Wisconsin registry for Alzheimer's prevention. Alzheimer's & Dementia, 1(2), 160-169.
View publication via DOI: DOI:10.1016/j.dadm.2015.01.003

Koscik, R. L., La, R. A., Jonaitis, E. M., Okonkwo, O. C., Johnson, S. C., Bendlin, B. B., Hermann, B. P., & Sager, M.A. (2014). Emergence of mild cognitive impairment in late-middle-aged adults in the Wisconsin Registry for Alzheimer's Prevention. Dementia and Geriatric Cognitive Disorders, 38(1-2), 16-30.
View publication via DOI: DOI:10.1159/000355682

Johnson, S. C., Christian, B. T., Okonkwo, O. C., Oh, J. M., Harding, S., Xu, G., . . . Bendlin, B. B., . . . Asthana, S., & Sager, M. A. (2014). Amyloid burden and neural function in people at risk for Alzheimer's disease. Neurobiology of Aging, 35(3), 576-584.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2013.09.028

Birdsill, A. C., Koscik, R. L., Jonaitis, E. M., Johnson, S. C., Okonkwo, O. C., Hermann, B. P., . . . Sager, M. A., & Bendlin, B. B. (2014). Regional white matter hyperintensities: Aging, Alzheimer's disease risk, and cognitive function. Neurobiology of Aging, 35(4), 769-776.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2013.10.072

Engelman, C. D., Koscik, R. L., Jonaitis, E. M., Hermann, B. P., La Rue, A., & Sager, M. A. (2014). Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin registry for Alzheimer's prevention. Neurobiology of Aging, 35(6), 1252-1254.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2013.11.013

Ly, M., Canu, E., Xu, G., Oh, J., McLaren, D. G., Dowling, N. M., ... Sager, M. A., Johnson, S. C., & Bendlin, B. B. (2014). Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults. Human Brain Mapping, 35(5), 2044-2054.
View publication via DOI: DOI:10.1002/hbm.22311

Okonkwo, O.C., Oh, J.M., Koscik, R., Jonaitis, E., Cleary, C.A., Dowling, N.M., Bendlin, B.B., LaRue, A., Hermann, B.P., Barnhart, T.E., Murali, D., Rowley, H.A., Carlsson, C.M., Gallagher, C.L., Asthana, S., Sager, M.A., Christian, B.T., & Johnson, S.C. (2014). Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. Journal of the International Neuropsychological Society, 20(4), 422-433.
View publication via DOI: DOI:10.1017/S1355617714000113

Racine, A.M., Adluru, N., Alexander, A.L., Christian, B.T., Okonkwo, O.C., Oh, J., Cleary, C.A., Birdsill, A., Hillmer, A.T., Murali, D., Barnhart, T.E., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Dowling, N.M., Asthana, S., Sager, M.A., Bendlin, B.B. (2014). Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation. NeuroImage: Clinical, 4, 604-614.
View publication via DOI: DOI:10.1016/j.nicl.2014.02.001

Adluru, N., Destiche, D.J., Lu, S., Doran, S.T., Birdsill, A.C., Melah, K.E., Okonkwo, O.C., Alexander, A.L., Dowling, N.M., Johnson, S.C., Sager, M.A., & Bendlin, B.B. (2014). White matter microstructure in late middle-age: Effects of Apolipoprotein E4 and parental family history of Alzheimer's disease. NeuroImage: Clinical, 4, 730-742.
View publication via DOI: DOI:10.1016/j.nicl.2014.04.008

Okonkwo, O.C., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R., Gallagher, C.L., Dowling, N.M., Carlsson, C.M., Bendlin, B.B., LaRue, A., Rowley, H.A., Christian, B.T., Asthana, S., Hermann, B.P., Johnson, S.C., & Sager, M.A. (2014). Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology, 83(19), 1753-1760.
View publication via DOI: DOI:10.1212/WNL.0000000000000964

Boots, E.A., Schultz, S.A., Oh, J.M., Larson, J., Edwards, D., Cook, D., Koscik, R.L., Dowling, M.N., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., LaRue, A., Asthana, S., Hermann, B.P., Sager, M.A., Johnson, S.C., & Okonkwo, O.C. (2014). Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease. Alzheimer's & Dementia, 10(4), p165.
View publication via DOI: DOI:10.1016/j.jalz.2014.04.163

Schultz, S.A., Larson, J., Oh, J., Koscik, R., Dowling, N.M., Gallagher, C.L., Carlsson, C.M., Rowley, H.A., Bendlin, B.B., Asthana, S., Hermann, B.P., Johnson, S.C., Sager, M., LaRue, A., & Okonkwo, O.C. (2014). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease. Brain Imaging and Behavior, 9(4), 729-736.
View publication via DOI: DOI:10.1007/s11682-014-9329-5

Willette, A. A., Johnson, S. C., Birdsill, A. C., Sager, M. A., Christian, B., Baker, L. D., Craft, S., Oh, J., Statz, E., Hermann, B. P., Jonaitis, E. M., Koscik, R. L., La Rue, A., Asthana, S., & Bendlin, B. B. (2014). Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimer's & Dementia, 11(5), 504-510.e1.
View publication via DOI: DOI:10.1016/j.jalz.2014.03.011

Okonkwo, O. C., Oh, J. M., Koscik, R., Jonaitis, E., Cleary, C. A., Dowling, N. M., Bendlin, B. B., LaRue, A., Hermann, B. P., Barnhart, T. E., Murali, D., Rowley, H. A., Carlsson, C. M., Gallagher, C. L., Asthana, S., Sager, M. A., Christian, B. T., & Jo (2014). Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. Journal of the International Neuropsychological Society, 20(04), 422-433.
View publication via DOI: DOI:10.1017/S1355617714000113

Okonkwo, O. C., Xu, G., Oh, J. M., Dowling, N. M., Carlsson, C. M., Gallagher, C. L., Birdsill, A. C., Palotti, M., Wharton, W., Hermann, B. P., LaRue, A., Bendlin, B. B., Rowley, H. A., Asthana, S., Sager, M. A., & Johnson, S. C. (2014). Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease. Cerebral Cortex, 24(4), 978-988.
View publication via DOI: DOI:10.1093/cercor/bhs381

Mielke, M.M., Haughey, N.J., Bandaru, V.V., Zetterberg, H., Blennow, K., Andreasson, U., Johnson, S.C., Gleason, C.E., Blazel, H.M., Puglielli, L., Sager, M.A., Asthana, S., & Carlsson, C.M. (2014). Cerebrospinal fluid sphingolipids, beta-amyloid, and tau in adults at risk for Alzheimer's disease. Neurobiological Aging, 35(11), 2486-2494.
View publication via DOI: DOI:10.1016/j.neurobiolaging.2014.05.019

Birdsill, A. C., Carlsson, C. M., Willette, A. W., Okonkwo, O. C., Johnson, S. C., Xu, G., ... Asthana, S., Sager, M. A., & Bendlin, B. B. (2013). Low cerebral blood flow is associated with lower memory function in metabolic syndrome. Obesity, 21(7), 1313-1320.
View publication via DOI: DOI:10.1002/oby.20170

Zuelsdorff, M. L., Engelman, C. D., Friedman, E. M., Koscik, R. L., Jonaitis, E. M., Rue, A. L., & Sager, M. A. (2013). Stressful events, social support, and cognitive function in middle-aged adults with a family history of Alzheimer's disease. Journal of Aging and Health, 25(6), 944-959.
View publication via DOI: DOI:10.1177/0898264313498416

Engelman, C. D., Koscik, R. L., Jonaitis, E. M., Okonkwo, O. C., Hermann, B. P., La Rue, A., & Sager, M. A. (2013). Interaction between two cholesterol metabolism genes influences memory: Findings from the Wisconsin registry for Alzheimer's prevention. Journal of Alzheimers Disease, 36(4), 749-757.
View publication via DOI: DOI:10.3233/jad-130482

Willette, A. A., Xu, G., Johnson, S. C., Birdsill, A. C., Jonaitis, E. M., Sager, M. A., ... Asthana, S., & Bendlin, B. B (2013). Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes Care, 36(2), 443-449.
View publication via DOI: DOI:10.2337/dc12-0922

Chang, T.S., Coen, M.H., La Rue, A., Jonaitis, E.M., Koscik, R.L., Hermann, B.P. & Sager, M.A. (2012). Machine learning amplifies the effect of parental family history of Alzheimer's disease on list learning strategy. Journal of the International Neuropsychological Society, 18(3), 428-439.
View publication via DOI: DOI:10.1017/S1355617711001834

Ries, M.L., McLaren, D.G., Bendlin, B.B., Xu, G., Rowley, H.A., Birn, R., Kastman, E.K., Sager, M.A., Asthana, S., & Johnson, S.C. (2012). Medial prefrontal functional connectivity: relation to memory self-appraisal accuracy in older adults with and without memory disorders. Neuropsychologia, 50(5), 603-611.
View publication via DOI: DOI:10.1016/j.neuropsychologia.2011.12.014

Okonkwo, O.C., Xu, G., Dowling, N.M., Bendlin, B.B., La Rue, A., Hermann, . . . Asthana, S., Sager, M.A. & Johnson, S.C. (2012). Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults. Neurology, 78(22), 1769-1776.
View publication via DOI: DOI:10.1212/WNL.0b013e3182583047

Bendlin, B.B., Carlsson, C.M., Johnson, S.C., Zetterberg, H., Blennow, K., Willette, A.A., Okonkwo, O. C., ... Puglielli, L., Asthana, S., & Sager, M.A. (2012). CSF t-tau/A 42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease. Public Library of Science One, 7(6), e37720.
View publication via DOI: DOI:10.1371/journal.pone.0037720

Wharton, W.L., Stein, J.H., Korcarz, C., Sachs, J., Olson, S.R., Zetterberg, H., ... Johnson, S.C., Sager, M.A., Asthana, S., Carlsson, C.M. (2012). The effects of Ramipril in individuals at risk for Alzheimer's disease: Results of a pilot clinical trial. Journal of Alzheimer's Disease, 1387-2877.
View publication via DOI: DOI:10.3233/JAD-2012-120763

Willette, A.A., Xu, G., Johnson, S.C., Birdsill, A.C., Jonaitis, E.M., Sager, M.A., ... Asthana, S., & Bendlin, B.B. (2012). Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes Care, 36(2), 443-449.
View publication via DOI: DOI:10.2337/dc12-0922

Okonkwo, O. C., Xu, G., Oh, J. M., Dowling, N. M., Carlsson, C. M., Gallagher, C., . . . Asthana, S., Sager, M. A., & Johnson, S. C. (2012). Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease. Cerebral Cortex. Advance online publication.
View publication via DOI: DOI:10.1093/cercor/bhs381

Carlsson, C.M., Xu, G., Wen, Z., Barnet, J.H., Blazel, H.M., Chappell, Stein, J.H., Asthana, S., Sager, M.A., ... Johnson, S.C. (2011). Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: A pilot study. Current Alzheimer Research, 9(8), 990-997.
View publication via DOI: DOI:10.2174/156720512803251075

Johnson, S.C., La Rue, A., Hermann, B.P., Xu, G., Koscik, R.L., Jonaitis, E.M., ... Asthana, S., Green, R.C., & Sager, M.A. (2011). The effect of TOMM40 poly-t length on gray matter volume and cognition in middle-aged persons with APOE ɛ3/ɛ3 genotype. Alzheimer's and Dementia, 7(4), 456-465.
View publication via DOI: DOI:10.1016/j.jalz.2010.11.012

Khachaturian, Z.S., Barnes, D., Einstein, R., Johnson, S., Lee, V., Roses, A., Sager, M.A., et. al. (2010). Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimer's & Dementia, 6(2), 89-97.
View publication via DOI: DOI:10.1016/j.jalz.2010.01.008

Bendlin, B.B., Newman, L.M., Ries, M.L., Puglielli, L., Carlsson, C.M., Sager, M.A., ... Asthana, S., & Johnson, S.C. (2010). NSAIDs may protect against age-related brain atrophy. Frontiers in Aging Neuroscience, 2(35).
View publication via DOI: DOI:10.3389/fnagi.2010.00035

Bendlin, B.B., Ries, M.L., Canu, E., Sodhi, A., Lazar, M., Alexander, A.L., Carlsson, C.M., Sager, M.A. Asthana, S., & Johnson, S. C. (2010). White matter is altered with parental family history of Alzheimer's disease. Alzheimer's & Dementia, 6(5), 394-403.
View publication via DOI: DOI:10.1016/j.jalz.2009.11.003

Ward, M. A., Bendlin, B. B., McLaren, D. G., Hess, T. M., Gallagher, C. L., Kastman, E. K., ... Asthana, S., .. Sager, M.A., & Johnson, S. C. (2010). Low HDL cholesterol is associated with lower gray matter volume in cognitively healthy adults. Frontiers in Aging Neuroscience, 2(29).
View publication via DOI: DOI:10.3389/fnagi.2010.00029

Xu, G., McLaren, D.G., Ries, M.L., Fitzgerald, M.E., Bendlin, B.B., Rowley, H.A., Sager, M.A., Atwood, C.S., Asthana, S., & Johnson, S.C. (2009). The influence of parental history of Alzheimer's disease and apolipoprotein E 4 on the BOLD signal during recognition memory. Brain, 132, 383-391.
View publication via DOI: DOI:10.1093/brain/awn254

Weimer, D.L., & Sager, M.A. (2009). Early identification and treatment of Alzheimer's disease: social and fiscal outcomes. Alzheimer's & Dementia, 5(3), 215-26.
View publication via DOI: DOI:10.1016/j.jalz.2009.01.028

Carlsson, C.M., Nondahl, D.M., Klein, B.E., McBride, P.E., Sager, M.A., Schubert, C.R., Klein, R., & Cruickshanks, K.J. (2009). Increased atherogenic lipoproteins are associated with cognitive impairment: effects of statins and subclinical atherosclerosis. Alzheimer Disease and Associated Disorders, 23(1), 11-17.
View publication via DOI: DOI:10.1097/WAD.0b013e3181850188

Asenath, L.R., Hermann, B., Jones, J., Johnson, S.C., Asthana, S., & Sager, M.A. (2008). Effect of family history of Alzheimer's disease on serial position profiles. Alzheimer's and Dementia, 4(4), 285-290.
View publication via DOI: DOI:10.1016/j.jalz.2008.03.009

Hermann, B., Seidenberg, M., Sager, M., Carlsson, C.M., Gidal, B., Sheth, R., Rutecki, P., & Asthana, S. (2008). Growing old with epilepsy: the neglected issue of cognitive and brain health in aging persons with chronic epilepsy. Epilepsia, 49(5), 731-740, 2008.
View publication via DOI: DOI:10.1111/j.1528-1167.2007.01435.x

Ries, M.L., Carlsson, C.M., Rowley, H.R., Sager, M.A., Gleason, C.E., Asthana, S., & Johnson, S.C. (2008). MRI characterization of brain structure and function in Mild Cognitive Impairment: A review. Journal of the American Geriatrics Society, 56(5), 920-934.
View publication via DOI: DOI:10.1111/j.1532-5415.2008.01684.x

Xu, G., Fitzgerald, M.E., Wen, Z., Fein, S., Alsop, D., Carroll, T., Ries, M., Rowley, H., Sager, M., Asthana, S., Johnson, S.C., & Carlsson, C.M. (2008). Atorvastatin therapy is associated with greater and faster cerebral hemodynamic response. Brain Imaging and Behavior, 2(2), 94-104.
View publication via DOI: DOI:10.1007/s11682-007-9019-7

Carlsson, C.M., Gleason, C.E., Hess, T.M., Moreland, K.A., Blazel, H.M., Koscik, R.L., Schreiber, N.T.N., Johnson, S.C., Atwood, C.S., Puglielli, L., Hermann, B.P., McBride, P.E., Stein, J.H., Sager, M.A., & Asthana, S. (2008). Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimers disease. Journal of Alzheimers Disease, 13(2), 187-97.

Trivedi, M.A., Schmitz, T.W., Ries, M.L., Hess, T.M., Fitzgerald, M.E., Atwood, C.S., Rowley, H.A., Asthana, S., Sager, M.A., & Johnson, S.C. (2008). fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: Risk factors for Alzheimer's disease. Neuropsychologia, 46(6), 1667-1678.
View publication via DOI: DOI:10.1016/j.neuropsychologia.2007.11.035

Johnson, S.C., Ries, M.L., Hess, T.M., Carlsson, C.M., Gleason, C.E., Alexander, A.L., Rowley, H.A., Asthana, S., & Sager, M.A. (2007). Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults. Archives of General Psychiatry, 64(10), 1163-1171.
View publication via DOI: DOI:10.1001/archpsyc.64.10.1163

Trivedi, M.A., Schmitz, T.W., Ries, M.L., Torgerson, B.M., Sager, M.A., Hermann, B.P., Asthana, S., & Johnson, S.C. (2006). Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk for Alzheimer's Disease: a cross-sectional study. BMC Medicine, 4, 1.
View publication via DOI: DOI:10.1186/1741-7015-4-1

Gleason, C.E., Schmitz, T.W., Hess, T., Koscik, R.L., Trivedi, M.A., Ries, M.L., Carlsson, C.M., Sager, M.A., Asthana, S., & Johnson, S.C. (2006). Hormone effects on fMRI and cognitive measures of encoding: Importance of hormone preparation. Neurology, 67, 2039-204.
View publication via DOI: DOI:10.1212/01.wnl.0000247277.81400.43

Johnson, S.C., Schmitz, T.W., Trivedi, M.A., Ries, M.L., Torgerson, B.M., Carlsson, C.M., Asthana, S., Hermann, B.P., & Sager, M.A. (2006). The influence of AD family history and APOE4 on mesial temporal lobe activation. Journal of Neuroscience, 26, 6069-607.
View publication via DOI: DOI:10.1523/JNEUROSCI.0959-06.2006

Ward, M.A., Carlsson, C.M., Trivedi, M.A., Sager, M.A., & Johnson, S.C. (2005). The effect of body mass index on global brain volume in middle-aged adults: A cross-sectional study. BMC Neurol., 5(23).
View publication via DOI: DOI:10.1186/1471-2377-5-23

Schraeder, C., Shelton, P.S., & Sager, M.A. (2001). The effects of a collaborative model of primary care on the mortality and hospital use of community-dwelling older adults. J. Geront., 56A(2), M106-M112.
View publication via DOI: DOI:10.1093/gerona/56.2.M106

Shelton, P.S., Schraeder, C., Dworak, D., Fraser, C., & Sager, M.A. (2001). Caregivers' utilization of health services: results from the Medicare Alzheimer's disease demonstration, Illinois site. J. Am. Geriatr. Soc., 49, 1600-1605.
View publication via DOI: DOI:10.1111/j.1532-5415.2001.49267.x

Shelton, P.S., Sager, M.A., & Schraeder, C. (2000). The Community Assessment Risk Screen (CARS): Identifying elderly persons at risk of a hospitalization or emergency room visit. Am. J. Managed Care, 6(8), 926-933.

Mahoney, J.E, Sager, M.A., & Jalaluddin, M. (1999). Use of an ambulation assistive device predicts functional decline associated with hospitalization. J. Gerontology Medical Sciences, 54A, M83-M88.
View publication via DOI: DOI:10.1093/gerona/54.2.M83

Mahoney, J.E., Sager, M.A., & Jalaluddin, M. (1998). New walking dependence associated with hospitalization for acute medical illness: Incidence and significance. J. Gerontology Medical Sciences, 53A, M307-312.
View publication via DOI: DOI:10.1093/gerona/53A.4.M307

Gray, S.L., Sager, M.A., Lestico, M.R., & Jalaluddin, M. (1998). Adverse drug events in hospitalized elderly. J. Geront., 53A(1), M59-M63.
View publication via DOI: DOI:10.1093/gerona/53A.1.M59

Sager, M.A., Rudberg, M., Jalaluddin, M., et al. (1996). Hospital Admission Risk Profile (HARP): Identifying older patients at risk for functional decline following acute medical illness and hospitalization. Journal of the American Geriatrics Society, 44, 251-257.

Sager, M.A., Franke, T., Inouye, S., et al. (1996). Functional outcomes of acute medical illness and hospitalization in older persons. Archives of Internal Medicine, 156, 645-652.

Sager, M., Dunham, N., Schwantes, A., et al. (1992). Measurement of activities of daily living in hospitalized elderly: A comparison of self-report and performance-based measures. Journal of the American Geriatrics Society, 40, 457-462.

Sager, M.A., Easterling, D.V., Kindig, D.A., & Anderson, O.W. (1989). Changes in the location of death after passage of medicare's prospective payment system. New England Journal of Medicine, 320, 433-439.

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