Untitled Document

Research

Neil C. Binkley

M.D., University of Wisconsin-Madison
Associate Professor, Department of Medicine
Associate Director, Institute on Aging Co-Director, Osteoporosis Clinical Center & Research Program
nbinkley@wisc.edu
http://www2.medicine.wisc.edu/home/people-search/people/staff/137/BINKLEY_NEIL_C/

The Role of Vitamins in Osteoporosis

Bone loss with advancing age often leads to osteoporosis. As such, the lifetime risk of osteoporotic fracture is ~40% in women and 25% in men. Our research activities focus on the role of nutrition in bone loss, use of bone mass measurement in the diagnosis and treatment of osteoporosis, etiology of male osteoporosis and optimal treatment of people with osteoporosis.

It has recently become appreciated that undiagnosed vitamin K insufficiency may contribute to bone loss. Additionally, high-dose supplementation with one K vitamer (MK4) preserves bone density and reduces osteoporotic fracture risk among postmenopausal women in Japan. We are currently the only location in North America which is evaluating the effect of MK4 compared to vitamin K1 (the type found in green vegetables) on bone density and serum measures of bone turnover. It may be that vitamin K supplementation will become a routine part of osteoporosis prevention and treatment.

Conversely, subclinical excess of vitamin A may be an unappreciated cause of bone loss. Though vitamin A deficiency remains common worldwide, it is present in many fortified foods and over-the counter supplements. Thus vitamin A excess may be common. Preliminary data suggest that this unappreciated excess may cause bone loss thereby increasing osteoporotic fracture risk. We are currently determining whether there is a correlation between serum concentration of vitamin A compounds and bone density or size.

Our other interests include the clinical use of bone densitometry (bone density measurement), its interpretation and optimization of its diagnostic utility as well as bone mass measurement in males and non-Caucasians. Additionally, our group is active in clinical trials of future osteoporosis treatment medications and is conducting the first trial of an osteoporosis treatment medication in nursing home residents.

Representative Publications
Binkley, N., Krueger, D., Gemar, D., & Drezner, M.K. (2008). Correlation among 25-hydroxy-vitamin D assays. J. Clin. Endocrinol. Metab., 93(5), 1804-8.

Danielson, K.K., Elliott, M.E., LeCaire, T., Binkley, N., & Palta, M. (2008). Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes. Osteoporos Int. 2008 Oct 2. [Epub ahead of print].

Hansen, K.E., Binkley, N., Blank, R.D., Krueger, D.C., Golembiewski, I., & Baim, S. (2007). An atlas of focal structural anomalies: Case series. Released in September 2007 by the International Society for Clinical Densitometry at http://www.iscd.org/fs.

Hansen, K.E., Binkley, N., Blank, R.D., Krueger, D.C., Christian, R.C., Malone, D.G., & Baim, S. (2007). An atlas improves interobserver agreement regarding application of the ISCD Vertebral Body Exclusion Criteria. Journal of Clinical Densitometry, 10(4), 359-6.

Hollis, B.W., Wagner, C.L., Drezner, M.K., & Binkley, N.C. (2007). Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status. J. Steroid Biochem. Mol. Biol., 103(3-5), 631-4.

Binkley, N., Novotny, R., Krueger, D., Kawahara, T., Daida, Y.G., Lensmeyer, G., Hollis, B.W., & Drezner, M.K. (2007). Low vitamin D status despite abundant sun exposure. J. Clin. Endocrinol. Metab., 92(6), 2130-5.

Binkley, N., Krueger, D., & Drezner, M.K. (2007). Low vitamin D status: time to recognize and correct a Wisconsin epidemic. W.M.J., 106(8), 466-72.

Blank, R.D., Malone, D.G., Christian, R.C., Vallarta-Ast, N., Krueger, D., Drezner, M.K., Binkley, N., & Hansen, K.E. (2006). Patient variables impact lumbar spine dual energy x-ray absorptiometry precision. Osteoporosis Int., 17, 768-74.

Lensmeyer, G.L., Wiebe, D.A., Binkley, N., & Drezner, M.K. (2006). HPLC method for 25-hydroxyvitamin D measurement: comparison with contemporary assays. Clin. Chem., 52(6), 1120-6.

Binkley, N., Drezner, M.K., & Hollis, B.W. (2006). Laboratory reporting of 25-hydroxyvitamin D results: potential for clinical misinterpretation. Clin. Chem., 52(11), 2124-5.

Hansen, K.E., Binkley, N., Christian, R., Blank, R.B., Vallarta-Ast, N., Krueger, D., Drezner, M.K., & Blank, R.B. (2005). Interobserver reproducibility of criteria for vertebral body exclusion. J. Bone Miner. Res., 20, 501-508.

Hansen, K.E., Vallarta-Ast, N., Krueger, D., Gangnon, R., Drezner, M.K., & Binkley, N. (2004). Use of the lowest vertebral body to diagnose lumbar osteoporosis in men: Is �cherry picking� appropriate? J. Clin. Densitom., 7(4), 376-381.

Binkley, N., Krueger, D., Cowgill, C.S., Plum, L., Lake, E., Hansen, K.E., DeLuca, H.F., & Drezner, M.K. (2004). Assay variation confounds the diagnosis of hypovitaminosis D: A call for standardization. J. Clin. Endocrinol. Metab., 89, 3152-3157.

Elliott, M.E., Drinka, P.J., Krause, P., Binkley, N.C., & Mahoney, J.E. (2004). Osteoporosis assessment strategies for male nursing home residents. Maturitas, 48, 225-233.

Elliott, M.E., & Binkley, N. (2004). Evaluation and measurement of bone mass. Epilepsy Behav., 5(Suppl. 2), S16-23.

Elliott, M.E., Petersen, K., Binkley, N.C., Carnes, M.L., Zimmerman, D.R., Kieser, M.A., Knapp, K., Behlke, J., & Ahmann, N. (2003). Fracture risks for women in long-term care: high prevalence of calcaneal osteoporosis and hypovitaminosis D. Pharmacotherapy, 23(6), 702-10.

Elliott, M.E., Martin, B.A., Kanous, N.L., Carnes, M.L., Komoroske, B., & Binkley, N.C. (2003). Osteoporosis risk in elderly nuns: Need for better recognition and treatment. Curr. Ther. Res., 64, 65-80.

Binkley, N., & Krueger, D. (2002). Peak now or pay later: The role of bone mass in osteoporosis. Sports Med. Update, Spring, 4-7.

Binkley, N., Kawahara, T., Yandow, D., & Krueger, D. (2002). Clinical vignette: Is Lateral Spine Densitometric Assessment equivalent to Lateral Radiography? J. Bone Miner. Res., 17, 1162-1163.

Kawahara, T.N., Krueger, D.C., Engelke, J.A., & Binkley, N.C. (2002). Short-term Vitamin A supplementation does not affect bone turnover in men. J. Nutr., 132, 1169-1172.

Binkley, N., Krueger, D., Engelke, J., Crenshaw, T., & Suttie, J. (2002). Vitamin K supplementation does not affect ovariectomy-induced bone loss in rats. Bone, 30, 897-900.

Binkley, N., & Krueger, D. (2002). Osteoporosis in men. Wisconsin Med. J., 101, 28-32.

Binkley, N., Schmeer, P., Wasnich, R., & Lenchik, L. (2002). What are the criteria by which a densitometric diagnosis of osteoporosis can be made in males and non-Caucasians? J. Clin. Densitom., 5(Suppl), S19-S27.

Binkley, N., Krueger, D., Kawahara, T., Engelke, J., & Suttie, J. (2002). High Phylloquinone Intake is required to maximally Gamma Carboxylate Osteocalcin. Am. J. Clin. Nutr., 76, 1055-1060.

Elliott, M.E., Binkley, N.C., Meek, P.D., Kanous, N.L, Schill, G., Weinswig, P. Bohlman, J., Zimpel, C., Jensen, B., Walters, D., Sutter, S., Peterson, A., & Peterson, R. (2002). Pharmacy-based bone mass meaurement to assess osteoporosis risk. Ann. Pharmacother., 36, 571-577.

Elliott, M.E., Binkley, N.C., Meek, P.D., Kanous, N.L., Schill, G., Weinswig, P., Bohlman, J., Zimpel, C., Jensen, B., Walters, D., Sutter, S., Peterson, A., & Peterson, R. (2002). Osteoporosis screening by community pharmacists: Use of national osteoporosis foundation guidelines. J. Amer. Pharm. Assoc., 42, 101-111.

Lata, P.F., Binkley, N.C., & Elliott, M.E. (2002). Acceptability of pharmacy-based bone density measurement by women and primary health care providers. Menopause, 9, 449-455.

Elliott, M.E., Drinka, P.J., Krause, P., Mahoney, J.E., & Binkley, N.C. (2001). Osteoporosis in institutionalized male veterans: Common but under-recognized. J. Bone Miner. Res., 16(Suppl 1), M349.

Elliott, M.E., Petersen, K., Binkley, N.C., Carnes, M.L., Zimmerman, D.R., Kieser, M.A., Knapp, K., Behlke, J., & Ahmann, N. (2001). Fracture risks in long term care: Osteoporosis and hypovitaminosis D. American College of Clinical Pharmacy Annual Meeting, Abstract 363, 200.

Haffa, A., Krueger, D., Bruner, J., Engelke, J., Gundberg, C., & Binkley, N. (2000). Diet or warfarin induced vitamin K insufficiency elevates circulating undercarboxylated osteocalcin without altering skeletal status in growing female rats. J. Bone Miner. Res., 15, 872-878.

Binkley, N., & Krueger, D. (2000). Hypervitaminosis A and bone: A review of the literature. Nutrition Rev., 58, 138-144.

Binkley, N. C., Krueger, D. C., Foley, A. L., Engelke, J. A., & Suttie, J. (2000). Vitamin K supplementation reduces serum under -carboxylated osteocalcin concentration in healthy adults. Am. J. Clin. Nutr. 72, 1523-1528.

Elliott, M.E., Farrah, R.M., Binkley, N.C., Carnes, M.L., & Gudmundsson, A. (2000). Management of glucocorticoid-induced osteoporosis in male veterans. Ann. Pharmacother., 34, 1380-1384.

Ramsey, J.J., Colman, R.J., Binkley, N.C., Christensen, J.D., Gresl, T.A., Kemnitz, J.W., & Weindruch, R. (2000). Dietary restriction and aging in rhesus monkeys: The University of Wisconsin Study. Exp. Gerontol., 35, 1131-1149.

Garber, A.K., Binkley, N.C., Krueger, D.C., & Suttie, J.W. (1999). Bioavailability of phylloquinone from food sources or a supplement. J. Nutr., 129, 1201-1203.

Elliott, M.E., Carnes, M.L., Meek, P.D., Binkley, N.C., Gudmundsson, A., & Sanchez, C. (1999). Osteoporosis: Suggested management strategies. Drug Policy Perspective, 5, 66-69.

Elliott, M.E., Binkley, N.C., Meek, P.D., & Kanous, N.L. (1999). Community pharmacy osteoporosis database project with the peripheral instantaneous x-ray imager (PIXI). American Association of Colleges of Pharmacy Annual Meeting, 100(Jul), 26.

Elliott, M.E., Klein, L.C., Carnes, M.L., Gudmundsson, A., Skoronski, R.M., & Binkley, N.C. (1998). Management of glucocorticoid-induced osteoporosis in male veterans. Bone, 2(5 suppl), s583.

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