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Annual
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ON AGING
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AGING NEWS:

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Training Grant-
Biology of Aging
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Neil Binkley

Neil C. Binkley

M.D., University of Wisconsin-Madison
Professor, Department of Medicine- Geriatrics
Associate Director, Institute on Aging; Co-Director, Osteoporosis Clinical Center & Research Program
nbinkley@wisc.edu
http://www.medicine.wisc.edu/people-search/people/staff/29/Binkley_Neil/


The Role of Vitamins in Osteoporosis

Bone loss with advancing age often leads to osteoporosis. As such, the lifetime risk of osteoporotic fracture is ~40% in women and 30% in men. Our research activities focus on the role of nutrition in bone loss, use of bone mass measurement in the diagnosis and treatment of osteoporosis, etiology of male osteoporosis and optimal treatment of people with osteoporosis.

It has become appreciated that vitamin D insufficiency is common and contributes to bone loss and perhaps other chronic diseases. Additionally, there is controversy regarding what constitutes low vitamin D, how to supplement and what target level should be achieved. We have completed work documenting that use of high-dose supplement regimens to replete vitamin D status is safe and effective in older adults. These data also demonstrate that there is a substantial between individual response to a given amount of vitamin D supplementation. We continue to build on our work evaluating vitamin D measurement methodology and have expanded into evaluating other non-skeletal effects of vitamin D insufficiency.

The evolution of fracture risk assessment tools and osteoporosis care are moving beyond bone to include comprehensive assessment of the musculoskeletal system. The impact of falls on fracture is well established, recently, the evaluation of sarcopenia, the age related decline in muscle mass, and it's impact on function, falls and fracture has been appreciated. Tools to assess lean muscle mass and diagnose sarcopenia are being evaluated for use in research and clinical settings. Our lab has done work using total body dual-energy x-ray absorptiometry to evaluate lean tissue and sarcopenia in older adults. We are also using jumping mechanography, a force platform that calculates maximum power, force and height from a series of jumps to evaluate function in older adults. These data demonstrate this is a safe and effective method to asses function and may be more sensitive to changes in muscle mass or activity than standard tools. Our long-term goals are to determine an effective way to identify sarcopenia, evaluate interventions and determine what impact this condition may have on fracture risk.

Our other interests include the clinical use of bone densitometry (bone density measurement), its interpretation and optimization of its diagnostic utility as well as bone mass measurement in males and non-Caucasians. Additionally, our group is active in clinical trials of future osteoporosis treatment medications and is conducting the first trial of an osteoporosis treatment medication in nursing home residents.



Representative Publications
Beaudart, C., Dawson, A., Shaw, S. C., Harvey, N. C., Kanis, J. A., Binkley, N., . . . Dennison, E. M. (2017). Nutrition and physical activity in the prevention and treatment of sarcopenia: Systematic review. Osteoporosis International. Advance online publication.
View publication via DOI: DOI:10.1007/s00198-017-3980-9

Binkley, N., Borchardt, G., Siglinsky, E., & Krueger, D. (2017). Does vitamin D metabolite measurement help predict 25(oh)D change following vitamin D supplementation? Endocrine Practice. Advance online publication.
View publication via DOI: DOI:10.4158/ep161517.or

Binkley, N., Coursin, D., Krueger, D., Iglar, P., Heiner, J., Illgen, R., . . . Hogan, K. (2017). Surgery alters parameters of vitamin D status and other laboratory results. Osteoporosis International, 28(3), 1013-1020.
View publication via DOI: DOI:10.1007/s00198-016-3819-9

Mikula, A. L., Hetzel, S. J., Binkley, N., & Anderson, P. A. (2017). Validity of height loss as a predictor for prevalent vertebral fractures, low bone mineral density, and vitamin D deficiency. Osteoporosis International. Advance online publication.
View publication via DOI: DOI:10.1007/s00198-017-3937-z

Krueger, D., Libber, J., Sanfilippo, J., Yu, H.J., Horvath, B., Miller, C., & Binkley, N. (2016). A DXA Whole Body Composition Cross-Calibration Experience: Evaluation with Humans, Spine and Whole Body Phantoms. Journal of Clinical Densitometry.
View publication via DOI: DOI:10.1016/j.jocd.2015.04.003

Pickhardt, P.J., Lauder, T., Pooler, B.D., Munoz del Rio, A., Rosas, H., Bruce, R.J., & Binkley, N. (2016). Effect of IV contrast on lumbar trabecular attenuation at routine abdominal CT. Osteoporosis International, 27(1):147-152.
View publication via DOI: DOI:10.1007/s00198-015-3224-9

Lee, S.J., Binkley, N., Lubner, M.G., Bruce, R.J., Ziemlewicz, T.J., & Pickhardt, P.J. (2016). Opportunistic screening for osteoporosis using the sagittal reconstruction from routine abdominal CT for combined assessment of vertebral fractures and density. Osteoporosis International, 27(3), 1131-6.
View publication via DOI: DOI:10.1007/s00198-015-3318-4

Sempos, C.T., Durazo-Arvizu, R.A., Binkley, N., Jones, J., Merkel, J.M., & Carter, G.D. (2016). Developing vitamin D dietary guidelines and the lack of 25-hydroxyvitamin D assay standardization: The ever-present past. Journal of Steroid Biochemistry and Molecular Biology, 164, 115-119.
View publication via DOI: DOI:10.1016/j.jsbmb.2015.08.027

Krueger, D., Siglinsky, E., Buehring, B., & Binkley, N. (2016). Total body less head measurement is most appropriate for lean mass assessment in adults. Journal of Clinical Densitometry. Advance online publication.
View publication via DOI: DOI:10.1016/j.jocd.2016.08.068

Binkley, N., Dawson-Hughes, B., Durazo-Arvizu, R., Thamm, M., Tian, L., Merkel, J. M., . . . Sempos, C. T. (2016). Vitamin D measurement standardization: The way out of the chaos. Journal of Steroid Biochemistry and Molecular Biology. Advance online publication.
View publication via DOI: DOI:10.1016/j.jsbmb.2016.12.002

Cosman, F., Crittenden, D. B., Adachi, J. D., Binkley, N., Czerwinski, E., Ferrari, S., . . . Grauer, A. (2016). Romosozumab treatment in postmenopausal women with osteoporosis. New England Journal of Medicine, 375(16), 1532-1543.
View publication via DOI: DOI:10.1056/NEJMoa1607948

Dempster, D. W., Zhou, H., Recker, R. R., Brown, J. P., Bolognese, M. A., Recknor, C. P., ... Binkley, N., ... Taylor, K. A. (2016). A longitudinal study of skeletal histomorphometry at 6 and 24 months across four bone envelopes in postmenopausal women with osteoporosis receiving teriparatide or zoledronic acid in the SHOTZ trial. Journal of Bone and Mineral Research, 31(7), 1429-1439.
View publication via DOI: DOI:10.1002/jbmr.2804

Lewiecki, E. M., & Binkley, N. (2016). What we don't know about osteoporosis. Journal of Endocrinological Investigation, 39(5), 491-493.
View publication via DOI: DOI:10.1007/s40618-016-0442-8

Lewiecki, E. M., Binkley, N., Morgan, S. L., Shuhart, C. R., Camargos, B. M., Carey, J. J., . . . Leslie, W. D. (2016). Best practices for dual-energy X-ray absorptiometry measurement and reporting: International society for clinical densitometry guidance. Journal of Clinical Densitometry, 19(2), 127-140.
View publication via DOI: DOI:10.1016/j.jocd.2016.03.003

Mikula, A. L., Hetzel, S. J., Binkley, N., & Anderson, P. A. (2016). Clinical height measurements are unreliable: A call for improvement. Osteoporosis International, 27(10), 3041-3047.
View publication via DOI: DOI:10.1007/s00198-016-3635-2

Ziemlewicz, T. J., Maciejewski, A., Binkley, N., Brett, A. D., Brown, J. K., & Pickhardt, P. J. (2016). Direct comparison of unenhanced and contrast-enhanced CT for opportunistic proximal femur bone mineral density measurement: Implications for osteoporosis screening. AJR, 206(4), 694-698.
View publication via DOI: DOI:10.2214/ajr.15.15128

Ziemlewicz, T. J., Maciejewski, A., Binkley, N., Brett, A. D., Brown, J. K., & Pickhardt, P. J. (2016). Opportunistic quantitative CT bone mineral density measurement at the proximal femur using routine contrast-enhanced scans: Direct comparison with DXA in 355 adults. Journal of Bone and Mineral Research, 31(10), 1835-1840.
View publication via DOI: DOI:10.1002/jbmr.2856

Crandall, C. J., Karlamangla, A. S., Merkin, S. S., Binkley, N., Carr, D., Greendale, G. A., & Seeman, T. E. (2015). Adult bone strength of children from single-parent families: The Midlife in the U.S. Study. Osteoporosis International, 26(3), 931-942.
View publication via DOI: DOI:10.1007/s00198-014-2990-0

Binkley, N., Lappe, J., Singh, R.J., Khosla, S., Krueger, D., Drezner, M.K., Blank, R.D. (2015). Can vitamin D metabolite measurements facilitate a "treat-to-target" paradigm to guide vitamin D supplementation? Osteoporosis International, 26(5), 1655-1660.
View publication via DOI: DOI:10.1007/s00198-014-3010-0

Ziegler, T.E., Kapor, A., Hedman, C.J., Binkley, N., & Kemnitz, J.W. (2015). Measurement of 25-hydroxyvitamin D2&3 by tandem mass spectrometry: A primate multispecies comparison. American Journal of Primatology, 77(7), 801-810.
View publication via DOI: DOI:10.1002/ajp.22403

Buehring, B., Krueger, D., Fidler, E., Gagnon, R., Heiderscheit, B., & Binkley, N. (2015). Reproducibility of jumping mechanography and traditional measures of physical and, muscle function in older adults. Osteoporosis International, (2), 819-25.
View publication via DOI: DOI:10.1007/s00198-014-2983-z

Ablove, T., Binkley, N., Leadley, S., Shelton, J., & Ablove, R. (2015). Body mass index continues to accurately predict percent body fat as women age despite changes in muscle mass and height. Menopause, 22(7).
View publication via DOI: DOI:10.1097/gme.0000000000000382

Lewiecki, E. M., Bilezikian, J. P., Binkley, N., Hans, D., Krueger, D., Miller, P. D., Oates, M., & Shane, E. (2015). Update on osteoporosis from the 2014 Santa Fe Bone symposium. Endocrine Research, 40(2), 106-119.
View publication via DOI: DOI:10.3109/07435800.2015.1005746

Rao, P., Millen, A. E., Meyers, K. J., Liu, Z., Voland, R., Sondel, S., Tinker, L., Wallace, R. B., Blodi, B. A., Binkley, N., Sarto, G., Robinson, J., LeBlanc, E., & Mares, J. A. (2015). The relationship between serum 25-hydroxyvitamin D levels and nuclear cataract in the carotenoid age-related eye study (CAREDS), an ancillary study of the women's health initiative. Investigative Ophthalmology and Visual Science, 56(8), 4221-4230.
View publication via DOI: DOI:10.1167/iovs.15-16835

Kujath, A.S., Quinn, L., Elliott, M.E., LeCaire, T.J., Binkley, N., Molino, A.R., & Danielson, K.K. (2015). Different health behaviors and clinical factors associated with bone mineral density and bone turnover in premenopausal women with and without type 1 diabetes. Diabetes/Metabolism Research and Reviews, 31:421-32.
View publication via DOI: DOI:10.1002/dmrr.2627

Krueger, D., Libber, J., & Binkley, N. (2015). Spine trabecular bone score (TBS) precision, a comparison between GE Lunar standard and high-resolution densitometers. Journal of Clinical Densitometry, 18:226-32.
View publication via DOI: DOI:10.1016/j.jocd.2014.11.003

Gepner, A.D., Haller, I.V., Krueger, D.C., Korcarz, C.E., Binkley, N., & Stein, J.H. (2015). A randomized controlled trial of the effects of vitamin D supplementation on arterial stiffness and aortic blood pressure in Native American women. Atherosclerosis, 240: 526-528.
View publication via DOI: DOI:10.1016/j.atherosclerosis.2015.04.795

Harvey, N., Gluer, C., Binkley, N., McCloskey, E.V., Brandi, M.-L., Cooper, C., Kendler, D., Lamy, O., Laslop, A., Camargos, B.M., Reginster, J.Y., Rizzoli, R., & Kanis, J.K. (2015). Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice. A consensus report of a European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) working group. Bone, 78:216-224.
View publication via DOI: DOI:10.1015/j.bone.2015.05.016

Lappe, J., & Binkley, N. (2015). Vitamin D and sarcopenia/falls. Journal of Clinical Densitometry, 18:478-82.
View publication via DOI: DOI:10.1016/j.jocd.2015.04.015

Binkley, N., & Cooper, C. (2015). Sarcopenia, the next frontier in fracture prevention: Introduction from the guest editors. Journal of Clinical Densitometry, 18:459-60.
View publication via DOI: DOI:10.1016/j.jocd.2015.05.067

Siglinsky, E., Krueger, D., Ward, R.E., Caserotti, P., Strotmeyer, E.S., Harris, T.B., Binkley, N., & Buehring, B. (2015). Effect of Age and Sex on Jumping Mechanography and Other Measures of Muscle Mass and Function. Journal of Muscoskeletal and Neuronal Interactions, 15(4):301-8.

Clynes, M.A., Edwards, M.H., Buehring, B., Dennison, E.M., Binkley, N., & Cooper, C. (2015). Definitions of sarcopenia: associations with falls and fracture in a population sample. Calcified Tissue International, 97(5):445-52.
View publication via DOI: DOI:10.1007/s00223-015-0044-z

Srikanthan, P., Crandall, C. J., Miller-Martinez, D., Seeman, T. E., Greendale, G. A., Binkley, N., & Karlamangla, A. S. (2014). Insulin resistance and bone strength. Findings from the study of Midlife in the United States. Journal of Bone and Mineral Research, 29(4), 796-803.
View publication via DOI: DOI:10.1002/jbmr.2083

Miller-Martinez, D., Seeman, T., Karlamangla, A. S., Greendale, G. A., Binkley, N., & Crandall, C. J. (2014). Marital histories, marital support, and bone density: Findings from the Midlife in the United States study. Osteoporosis International, 25(4), 1327-1335.
View publication via DOI: DOI:10.1007/s00198-013-2602-4

Buehring, B., Krueger, D., Fidler, E., Gangnon, R., Heiderscheit, B.C., & Binkley, N. (2014). Reproducibility of jumping mechanography and traditional measures of physical and muscle function in older adults. Osteoporosis International.
View publication via DOI: DOI:10.1007/s00198-014-2983-z

Buehring, B., Krueger, D., Libber, J., Heiderscheit, B., Sanfilippo, J., & Binkley, N. (2014). Dual-energy X-ray absorptiometry measured regional body composition least significant change: Effect of region of interest and gender in athletes. Journal of Clinical Densitomotry, 17(1), 121-8.
View publication via DOI: DOI:10.1016/j.jocd.2013.02.012

Binkley, N., Adler, R., & Bilezikian, J. P. (2014). Osteoporosis diagnosis in men: The T-score controversy revisited. Current Osteoporosis Reports, 12(4), 403-409.
View publication via DOI: DOI:10.1007/s11914-014-0242-z

Binkley, N., Bone, H., Gilligan, J. P., & Krause, D. S. (2014). Efficacy and safety of oral recombinant calcitonin tablets in postmenopausal women with low bone mass and increased fracture risk: A randomized, placebo-controlled trial. Osteoporosis International, 25(11), 2649-2656.
View publication via DOI: DOI:10.1007/s00198-014-2796-0

Binkley, N., & Sempos, C. T. (2014). Standardizing vitamin D assays: The way forward. Journal of Bone and Mineral Research 29(8), 1709-1714.
View publication via DOI: DOI:10.1002/jbmr.2252

Kujath, A. S., Quinn, L., Elliott, M. E., LeCaire, T. J., Binkley, N., Molino, A. R., & Danielson, K. K. (2014). Different health behaviours and clinical factors associated with bone mineral density and bone turnover in premenopausal women with and without type 1 diabetes. Diabetes/Metabolism Research and Reviews, 31(4), 421-432.
View publication via DOI: DOI:10.1002/dmrr.2627

Mori, T., Karlamangla, A. S., Merkin, S. S., Crandall, C. J., Binkley, N., Greendale, G. A., & Seeman, T. E. (2014). Multisystem dysregulation and bone strength: Findings from the study of Midlife in the United States. The Journal of Clinical Endocrinology and Metabolism, 99(5), 1843-1851.
View publication via DOI: DOI:10.1210/jc.2013-3908

Skarphedinsdottir, S. J., Sigurdsson, M. I., Coursin, D. B., Head, D. E., Springman, S. R., Wang, S., Chen, G., Li, Q., Krueger, D. C., Binkley, N., Sigurdsson, G. H., & Hogan, K. J. (2014). Vitamin D deficiency in anesthesia department caregivers at the end of winter. Acta Anaesthesiologica Scandinavica, 58(7), 802-806.
View publication via DOI: DOI:10.1111/aas.12316

Wiebe, D., & Binkley, N. (2014). Case report: Three patients with substantial serum levels of 3-epi-25(OH)D including one with 3-epi-25(OH)D2 while on high-dose ergocalciferol. The Journal of Clinical Endocrinology and Metabolism, 99(4), 1117-1121.
View publication via DOI: DOI:10.1210/jc.2013-3953

Buehring, B., Krueger, D., & Binkley, N. (2013). Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence. Journal of Cachexia, Sarcopenia and Muscle, 4(1), 47-54.
View publication via DOI: DOI:10.1007/s13539-012-0080-8

Lang, J. M., Wallace, M., Becker, J. T., Eickhoff, J. C., Buehring, B., Binkley, N., . . . McNeel, D. G. (2013). A randomized phase II trial evaluating different schedules of zoledronic acid on bone mineral density in patients with prostate cancer beginning androgen deprivation therapy. Clinical Genitourinary Cancer, 11(4), 407-415.
View publication via DOI: DOI:10.1016/j.clgc.2013.04.029

Buehring, B., Hind, J., Fidler, E., Krueger, D., Binkley, N., & Robbins, J. (2013). Tongue strength is associated with jumping mechanography performance and handgrip strength but not with classic functional tests in older adults. Journal of the American Geriatrics Society, 61(3), 418-422.
View publication via DOI: DOI:10.1111/jgs.12124

Buehring, B., Viswanathan, R., Binkley, N., & Busse, W. (2013). Glucocorticoid-induced osteoporosis: An update on effects and management. Journal of Allergy and Clinical Immunology, 132(5), 1019-1030.
View publication via DOI: DOI:10.1016/j.jaci.2013.08.040

Buehring, B., & Binkley, N. (2013). Myostatin - The Holy Grail for muscle, bone, and fat? Current Osteoporosis Reports, 11(4), 407-414.
View publication via DOI: DOI:10.1007/s11914-013-0160-5

Binkley, N., Krueger, D., & Buehring, B. (2013). What's in a name revisited: Should osteoporosis and sarcopenia be considered components of "dysmobility syndrome?" Osteoporosis International. Advance online publication.
View publication via DOI: DOI:10.1007/s00198-013-2427-1

Paparodis, R., Buehring, B., Pelley, E. M., & Binkley, N. (2013). A case of an unusual subtrochanteric fracture in a patient receiving denosumab. Endocrine Practice, 19(3), e64-68.
View publication via DOI: DOI:10.4158/ep12367.cr

Krueger, D., Vallarta-Ast, N., Libber, J., Checovich, M., Gangnon, R., & Binkley, N. (2013). Positioner and clothing artifact can affect one-third radius BMD measurement. Journal of Clinical Densiometry, 16(2), 154-159.
View publication via DOI: DOI:10.1016/j.jocd.2012.02.007

Karlamangla, A. S., Mori, T., Merkin, S. S., Seeman, T. E., Greendale, G. A., Binkley, N., & Crandall, C. J. (2013). Childhood socioeconomic status and adult femoral neck bone strength: Findings from the Midlife in the United States Study. Bone, 56(2), 320-326.
View publication via DOI: DOI:10.1016/j.bone.2013.06.021

Buehring, B., Krueger, D., Libber, J., Heiderscheit, B., Sanfilippo, J., Johnson, B., . . . Binkley, N (2013). Dual-energy X-ray absorptiometry measured regional body composition least significant change: Effect of region of interest and gender in athletes Journal of Clinical Densitometry. Advance online publication.
View publication via DOI: DOI:10.1016/j.jocd.2013.02.012

Lang, J. M., Wallace, M., Becker, J. T., Eickhoff, J. C., Buehring, B., Binkley, N., . . . Wilding, G. . . . McNeel, D. G. (2013). A randomized phase II trial evaluating different schedules of zoledronic acid on bone mineral density in patients with prostate cancer beginning androgen deprivation therapy. Clinical Genitourinary Cancer, 11(4), 407-415.
View publication via DOI: DOI:10.1016/j.clgc.2013.04.029

Binkley, N., & Wiebe, D. (2013). Clinical controversies in vitamin D: 25(OH)D measurement, target concentration, and supplementation. Journal of Clinical Densitometry, 16(4), 402-408.
View publication via DOI: DOI:10.1016/j.jocd.2013.08.006

Crandall, C., Miller-Martinez, D., Greendale, G., Binkley, N., Seeman, T., & Karlamangla, A. (2012). Socioeconomic status, race, and bone turnover in the Midlife in the US Study. Osteoporosis international, 23(5), 1503-1512.
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View publication via DOI: DOI:10.1007/s00198-011-1736-5

Krueger, D., Vallarta-Ast, N., Checovich, M., Gemar, D., & Binkley, N. (2012). BMD Measurement and Precision: A Comparison of GE Lunar Prodigy and iDXA densitometers. Journal of Clinical Densitometry, 15(1), 21-25.
View publication via DOI: DOI:10.1016/j.jocd.2011.08.003

Binkley, N. (2012). Vitamin D and Osteoporosis-related Fracture. Archives of Biochemistry and Biophysics, 523(1), 115-22.
View publication via DOI: DOI:10.1016/j.abb.2012.02.004

Gepner, A.D., Ramamurthy, R., Krueger, D.C., Korcarz, C.E., Binkley, N., & Stein, J.H. (2012). A prospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular disease risk. PLoS ONE, 7(5), e36617.
View publication via DOI: DOI:10.1371/journal.pone.0036617

Crandall, C.J., Merkin, S.S., Seeman, T.E., Greendale, G.A., Binkley, N., Karlmangla, & A.S. (2012). Socioeconomic status over the life-course and adult bone mineral density: The Midlife in the U. S. Study. Bone, 51(1), 107-13.
View publication via DOI: DOI:10.1016/j.bone.2012.04.009

Binkley, N., Ramamurthy, R., & Krueger, D. (2012). Low vitamin D status: definition, prevalence, consequences, and correction. Rheumatic Disease Clinics of North America, 38(1), 45-59.
View publication via DOI: DOI:10.1016/j.rdc.2012.03.006

Kijowski, R., Tuite, M., Krueger, D., Munoz Del Rio, A., Kleerekopfer, M., & Binkley, N. (2012). Evaluation of trabecular architecture in non-osteoporotic postmenopausal women with and without fracture. Journal of Bone and Mineral Research, 27(7), 1494-1500.
View publication via DOI: DOI:10.1002/jbmr.1595

Lewiecki, E.M., & Binkley, N. (2012). Bone Density Testing Intervals and Common Sense. Current Osteoporosis Reports, 10(3), 217-220.
View publication via DOI: DOI:10.1007/s11914-012-0111-6

Crandall, C. J., Merkin, S. S., Seeman, T. E., Greendale, G. A., Binkley, N., & Karlamangla, A. S. (2012). Socioeconomic status over the life-course and adult bone mineral density: The Midlife in the U.S. Study Bone, 51(1), 107-113.
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View publication via DOI: DOI:10.1016/j.bone.2012.04.009

Binkley, N., Gemar, D., Engelke, J., Gangnon, R., Ramamurthy, R., Krueger, D., & Drezner, M.K. (2011). Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50,000 IU monthly, in older adults. The Journal of Clinical Endocrinology & Metabolism, 96(4), 981-988.
View publication via DOI: DOI:10.1210/jc.2010-0015

Ozer, B.H., Krueger, D., & Binkley, N. (2010). Slight abduction/adduction deviations in femur positioning for dual-energy X-ray absorptiometry are inconsequential. Journal of Clinical Densitometry, 13(1), 10-7.
View publication via DOI: DOI:10.1016/j.jocd.2009.09.003

Orwoll, E.S., Binkley, N.C., Lewiecki, E.M., Gruntmanis, U., Fries, M.A., & Dasic, G. (2010). Efficacy and safety of monthly ibandronate in men with low bone density. Bone, 46(4), 970-6.
View publication via DOI: DOI:10.1016/j.bone.2009.12.034

Binkley, N., Ramamurthy, R., Krueger, D. (2010). Low vitamin D status: Definition, prevalence, consequences and correction. Endocrinology and Metabolism Clinics of North America, 39, 287-301.
View publication via DOI: DOI:10.1016/j.ecl.2010.02.008

Buehring, B., Krueger, D., Binkley, N. (2010). Jumping mechanography: A potential tool for sarcopenia evaluation in older individuals. Journal of Clinical Densitometry, 13, 283-291.
View publication via DOI: DOI:10.1016/j.jocd.2010.04.002

Binkley, N., Krueger, D., Morgan, S., Wiebe, D. (2010). Current status of clinical 25-hydroxyvitamin D measurement: An assessment of between-laboratory agreement. Clinica Chimica Acta, 411, 1976-1982.
View publication via DOI: DOI:10.1016/j.cca.2010.08.018

Buehring, B., Krueger, D., Checovich, M., Gemar, D., Vallarta-Ast, N., Genant, H.K., & Binkley, N. (2010). Vertebral fracture assessment: impact of instrument and reader. Osteoporosis International, 21(3), 487-94.
View publication via DOI: DOI:10.1007/s00198-009-0972-4

Danielson, K.K., Elliott, M.E., LeCaire, T., Binkley, N., & Palta, M. (2009). Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes. Osteoporos Int., 20(6), 923-933.
View publication via DOI: DOI:10.1007/s00198-008-0763-3

Binkley, N., Harke, J., Krueger, D., Engelke, J., Vallarta-Ast, N., Gemar, D., Checovich,M., Chappell, R., & Suttie, J. (2009). Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. Journal of Bone and Mineral Research, 24(6), 983-91.
View publication via DOI: DOI:10.1359/JBMR.081254

Binkley, N., Ringe, J.D., Reed, J.I., Ljunggren, O., Holick, M.F., Minne, H.W., Liu, M., Lamotta, A., West, J.A., & Santora, A.C. (2009). Alendronate/vitamin D3 70 mg/2800 IU with and without additional 2800 IU vitamin D3 for osteoporosis: results from the 24-week extension of a 15-week randomized, controlled trial. Bone, 44(4), 639-47.
View publication via DOI: DOI:10.1016/j.bone.2008.05.002

Binkley, N., Martens, M.G., Silverman, S.L., Derman, R.J., Greenwald, M.., Kohles, D., & Bachmann, G.A. (2009). Improved GI tolerability with monthly ibandronate in women previously using weekly bisphosphonates. Southern Medical Journal, 102(5), 486-92.
View publication via DOI: DOI:10.1097/SMJ.0b013e31819ed0dd

Binkley, N. (2009). Is vitamin D the fountain of youth? [Review]. Endocrine Practice, 15(6), 590-596.
View publication via DOI: DOI:10.4158/EP09115.RA

Lewiecki, E.M., & Binkley, N. (2009). Evidence-based medicine, clinical practice guidelines, and common sense in the management of osteoporosis. [Review]. Endocrine Practice, 15(6), 573-9.
View publication via DOI: DOI:10.4158/EP09107.RA

Watts, N.B., Lewiecki, E.M., Bonnick, S.L., Laster, A.J., Binkley, N., Blank, R.D., Geusens, P.P., Miller, P.D., Petak, S.M., Recker, R.R., Saag, K.G., Schousboe, J., Siris, E.S., & Bilezikian, J.P. (2009). Clinical value of monitoring BMD in patients treated with bisphosphonates for osteoporosis. [Review]. Journal of Bone and Mineral Research, 24(10), 1643-1646.
View publication via DOI: DOI:10.1359/jbmr.090818

Binkley, N., & Buehring, B. (2009). Beyond FRAX: it's time to consider "sarco-osteopenia". Journal of Clinical Densitometry, 12(4), 413-416.
View publication via DOI: DOI:10.1016/j.jocd.2009.06.004

Binkley, N., Krueger, D., & Lensmeyer, G. (2009). 25-hydroxyvitamin D measurement, 2009: a review for clinicians. Journal of Clinical Densitometry, 12(4), 417-427.
View publication via DOI: DOI:10.1016/j.jocd.2009.06.001

Binkley, N. (2009). A perspective on male osteoporosis. [Review]. Best Practice & Research. Clinical Rheumatology, 23(6), 755-68.
View publication via DOI: DOI:10.1016/j.berh.2009.10.001

Lips, P., Binkley, N., Pfeifer, M., Recker, R., Samanta, S., Cohn, D.A., Chandler, J., Rosenberg, E., & Papanicolaou, D.A. (2009). Once-weekly dose of 8400 IU vitamin D(3) compared with placebo: effects on neuromuscular function and tolerability in older adults with vitamin D insufficiency. The American Journal of Clinical Nutrition, 91(4), 985-91.
View publication via DOI: DOI:10.3945/​ajcn.2009.28113

Binkley, N., Ramamurthy, R., Krueger, D., & Buehring, B. (2009). Advances in osteoporosis care for older adults. Clinical Geriatrics, 17(2), 35-40.

Binkley, N., Krueger, D., Gemar, D., & Drezner, M.K. (2008). Correlation among 25-hydroxy-vitamin D assays. J. Clin. Endocrinol. Metab., 93(5), 1804-8.
View publication via DOI: DOI:10.1210/jc.2007-2340

Przybelski, R., Agrawal, A., Krueger, D., Engelke, J.A., Walbrun, F., Binkley, N. (2008). Rapid correction of low vitamin D status in nursing home residents. Osteoporosis International, 19, 1621-1628.
View publication via DOI: DOI:10.1007/s00198-008-0619-x

Hansen, K.E., Binkley, N., Blank, R.D., Krueger, D.C., Christian, R.C., Malone, D.G., & Baim, S. (2007). An atlas improves interobserver agreement regarding application of the ISCD Vertebral Body Exclusion Criteria. Journal of Clinical Densitometry, 10(4), 359-6.
View publication via DOI: DOI:10.1016/j.jocd.2007.08.003

Hollis, B.W., Wagner, C.L., Drezner, M.K., & Binkley, N.C. (2007). Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status. J. Steroid Biochem. Mol. Biol., 103(3-5), 631-4.
View publication via DOI: DOI:10.1016/j.jsbmb.2006.12.066

Binkley, N., Novotny, R., Krueger, D., Kawahara, T., Daida, Y.G., Lensmeyer, G., Hollis, B.W., & Drezner, M.K. (2007). Low vitamin D status despite abundant sun exposure. J. Clin. Endocrinol. Metab., 92(6), 2130-5.
View publication via DOI: DOI:10.1210/jc.2006-2250

Binkley, N., Krueger, D., & Drezner, M.K. (2007). Low vitamin D status: Time to recognize and correct a Wisconsin epidemic. W.M.J., 106(8), 466-72.

Przybelski, N., Binkley, N. (2007). Is vitamin D important for preserving cognition? Archives of Biochemistry and Biophysics, 460, 202-205.
View publication via DOI: DOI:10.1016/j.abb.2006.12.018

Binkley, N., Krueger, D., Engelke, J., Suttie, J.W. (2007). Vitamin K deficiency from long-term warfarin anticoagulation does not alter skeletal status in male rhesus monkeys. Journal of Bone and Mineral Research, 22, 695-700.
View publication via DOI: DOI:10.1359/jbmr.070208

Binkley, N. (2007). Does low vitamin D status contribute to "age-related" morbidity? Journal of Bone and Mineral Research, 22(Suppl 2), V55-V58.
View publication via DOI: DOI:10.1359/jbmr.07s212

Blank, R.D., Malone, D.G., Christian, R.C., Vallarta-Ast, N., Krueger, D., Drezner, M.K., Binkley, N., & Hansen, K.E. (2006). Patient variables impact lumbar spine dual energy x-ray absorptiometry precision. Osteoporosis Int., 17, 768-74.
View publication via DOI: DOI:10.1007/s00198-005-0050-5

Lensmeyer, G.L., Wiebe, D.A., Binkley, N., & Drezner, M.K. (2006). HPLC method for 25-hydroxyvitamin D measurement: comparison with contemporary assays. Clin. Chem., 52(6), 1120-6.
View publication via DOI: DOI:10.1373/clinchem.2005.064956

Binkley, N., Drezner, M.K., & Hollis, B.W. (2006). Laboratory reporting of 25-hydroxyvitamin D results: Potential for clinical misinterpretation. Clin. Chem., 52(11), 2124-5.
View publication via DOI: DOI:10.1373/clinchem.2006.074922

Vallarta-Ast, N., Krueger, D., Binkley, N. (2006). Addition of right lateral decubitus positioning improves vertebral visualization with VFA in selected patients. Journal of Clinical Densitometry, 6, 375-379.
View publication via DOI: DOI:10.1016/j.jocd.2006.05.009

Hansen, K.E., Binkley, N., Christian, R., Blank, R.B., Vallarta-Ast, N., Krueger, D., Drezner, M.K., & Blank, R.B. (2005). Interobserver reproducibility of criteria for vertebral body exclusion. J. Bone Miner. Res., 20, 501-508.
View publication via DOI: DOI:10.1359/JBMR.041134

Hansen, K.E., Vallarta-Ast, N., Krueger, D., Gangnon, R., Drezner, M.K., & Binkley, N. (2004). Use of the lowest vertebral body to diagnose lumbar osteoporosis in men: Is "cherry picking" appropriate? J. Clin. Densitom., 7(4), 376-381.
View publication via DOI: DOI:10.1385/JCD:7:4:376

Binkley, N., Krueger, D., Cowgill, C.S., Plum, L., Lake, E., Hansen, K.E., DeLuca, H.F., & Drezner, M.K. (2004). Assay variation confounds the diagnosis of hypovitaminosis D: A call for standardization. J. Clin. Endocrinol. Metab., 89, 3152-3157.
View publication via DOI: DOI:10.1210/jc.2003-031979

Elliott, M.E., Drinka, P.J., Krause, P., Binkley, N.C., & Mahoney, J.E. (2004). Osteoporosis assessment strategies for male nursing home residents. Maturitas, 48, 225-233.
View publication via DOI: DOI:10.1016/j.maturitas.2003.11.005

Elliott, M.E., & Binkley, N. (2004). Evaluation and measurement of bone mass. Epilepsy Behav., 5(Suppl. 2), S16-23.
View publication via DOI: DOI:10.1016/j.yebeh.2003.11.027

Elliott, M.E., Petersen, K., Binkley, N.C., Carnes, M.L., Zimmerman, D.R., Kieser, M.A., Knapp, K., Behlke, J., & Ahmann, N. (2003). Fracture risks for women in long-term care: high prevalence of calcaneal osteoporosis and hypovitaminosis D. Pharmacotherapy, 23(6), 702-10.
View publication via DOI: DOI:10.1592/phco.23.6.702.32182

Elliott, M.E., Martin, B.A., Kanous, N.L., Carnes, M.L., Komoroske, B., & Binkley, N.C. (2003). Osteoporosis risk in elderly nuns: Need for better recognition and treatment. Curr. Ther. Res., 64, 65-80.
View publication via DOI: DOI:10.1016/S0011-393X(03)00017-1

Binkley, N., & Krueger, D. (2002). Peak now or pay later: The role of bone mass in osteoporosis. Sports Med. Update, Spring, 4-7.

Binkley, N., Kawahara, T., Yandow, D., & Krueger, D. (2002). Clinical vignette: Is Lateral Spine Densitometric Assessment equivalent to Lateral Radiography? J. Bone Miner. Res., 17, 1162-1163.
View publication via DOI: DOI:10.1359/jbmr.2002.17.7.1162

Kawahara, T.N., Krueger, D.C., Engelke, J.A., & Binkley, N.C. (2002). Short-term Vitamin A supplementation does not affect bone turnover in men. J. Nutr., 132, 1169-1172.

Binkley, N., Krueger, D., Engelke, J., Crenshaw, T., & Suttie, J. (2002). Vitamin K supplementation does not affect ovariectomy-induced bone loss in rats. Bone, 30, 897-900.
View publication via DOI: DOI:10.1016/S8756-3282(02)00734-2

Binkley, N., & Krueger, D. (2002). Osteoporosis in men. Wisconsin Med. J., 101, 28-32.

Binkley, N., Schmeer, P., Wasnich, R., & Lenchik, L. (2002). What are the criteria by which a densitometric diagnosis of osteoporosis can be made in males and non-Caucasians? J. Clin. Densitom., 5(Suppl), S19-S27.
View publication via DOI: DOI:10.1385/JCD:5:3S:S19

Binkley, N., Krueger, D., Kawahara, T., Engelke, J., & Suttie, J. (2002). High Phylloquinone Intake is required to maximally Gamma Carboxylate Osteocalcin. Am. J. Clin. Nutr., 76, 1055-1060.

Vallarta-Ast, N., Krueger, D., & Binkley, N. (2002). Densitometric diagnosis of osteoporosis in men: Effect of measurement site and normative database. J. Clin. Densitom., 5(4), 383-389.
View publication via DOI: DOI:10.1385/JCD:5:4:383

Elliott, M.E., Binkley, N.C., Meek, P.D., Kanous, N.L, Schill, G., Weinswig, P. Bohlman, J., Zimpel, C., Jensen, B., Walters, D., Sutter, S., Peterson, A., & Peterson, R. (2002). Pharmacy-based bone mass meaurement to assess osteoporosis risk. Ann. Pharmacother., 36, 571-577.
View publication via DOI: DOI:10.1345/aph.1A299

Elliott, M.E., Binkley, N.C., Meek, P.D., Kanous, N.L., Schill, G., Weinswig, P., Bohlman, J., Zimpel, C., Jensen, B., Walters, D., Sutter, S., Peterson, A., & Peterson, R. (2002). Osteoporosis screening by community pharmacists: Use of national osteoporosis foundation guidelines. J. Amer. Pharm. Assoc., 42, 101-111.

Lata, P.F., Binkley, N.C., & Elliott, M.E. (2002). Acceptability of pharmacy-based bone density measurement by women and primary health care providers. Menopause, 9, 449-455.

Elliott, M.E., Drinka, P.J., Krause, P., Mahoney, J.E., & Binkley, N.C. (2001). Osteoporosis in institutionalized male veterans: Common but under-recognized. J. Bone Miner. Res., 16(Suppl 1), M349.

Elliott, M.E., Petersen, K., Binkley, N.C., Carnes, M.L., Zimmerman, D.R., Kieser, M.A., Knapp, K., Behlke, J., & Ahmann, N. (2001). Fracture risks in long term care: Osteoporosis and hypovitaminosis D. American College of Clinical Pharmacy Annual Meeting, Abstract 363, 200.

Haffa, A., Krueger, D., Bruner, J., Engelke, J., Gundberg, C., & Binkley, N. (2000). Diet or warfarin induced vitamin K insufficiency elevates circulating undercarboxylated osteocalcin without altering skeletal status in growing female rats. J. Bone Miner. Res., 15, 872-878.
View publication via DOI: DOI:10.1359/jbmr.2000.15.5.872

Binkley, N., & Krueger, D. (2000). Hypervitaminosis A and bone: A review of the literature. Nutrition Rev., 58, 138-144.
View publication via DOI: DOI:10.1111/j.1753-4887.2000.tb01848.x

Binkley, N. C., Krueger, D. C., Foley, A. L., Engelke, J. A., & Suttie, J. (2000). Vitamin K supplementation reduces serum under -carboxylated osteocalcin concentration in healthy adults. Am. J. Clin. Nutr. 72, 1523-1528.

Elliott, M.E., Farrah, R.M., Binkley, N.C., Carnes, M.L., & Gudmundsson, A. (2000). Management of glucocorticoid-induced osteoporosis in male veterans. Ann. Pharmacother., 34, 1380-1384.

Ramsey, J.J., Colman, R.J., Binkley, N.C., Christensen, J.D., Gresl, T.A., Kemnitz, J.W., & Weindruch, R. (2000). Dietary restriction and aging in rhesus monkeys: The University of Wisconsin Study. Exp. Gerontol., 35, 1131-1149.

Garber, A.K., Binkley, N.C., Krueger, D.C., & Suttie, J.W. (1999). Bioavailability of phylloquinone from food sources or a supplement. J. Nutr., 129, 1201-1203.

Elliott, M.E., Carnes, M.L., Meek, P.D., Binkley, N.C., Gudmundsson, A., & Sanchez, C. (1999). Osteoporosis: Suggested management strategies. Drug Policy Perspective, 5, 66-69.

Elliott, M.E., Binkley, N.C., Meek, P.D., & Kanous, N.L. (1999). Community pharmacy osteoporosis database project with the peripheral instantaneous x-ray imager (PIXI). American Association of Colleges of Pharmacy Annual Meeting, 100(Jul), 26.

Elliott, M.E., Klein, L.C., Carnes, M.L., Gudmundsson, A., Skoronski, R.M., & Binkley, N.C. (1998). Management of glucocorticoid-induced osteoporosis in male veterans. Bone, 2(5 suppl), s583.

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